INT123413

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 1.05
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Tpr) molecular_function (Tpr)
Anatomy Link Frequency
SH-SY5Y 1
P19 1
proximal 1
Tpr (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 31 99.80 Very High Very High Very High
Morphine 7 73.16 Quite High
Analgesic 3 70.44 Quite High
Opioid 3 50.00 Quite Low
cytokine 4 29.48 Quite Low
Inflammation 4 29.08 Quite Low
Pain 4 19.24 Low Low
Dopamine 4 8.96 Low Low
imagery 36 5.00 Very Low Very Low Very Low
isoflurane 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 79 99.56 Very High Very High Very High
Cytomegalovirus Infection 82 90.72 High High
Targeted Disruption 44 82.84 Quite High
Cancer 147 60.96 Quite High
Syndrome 24 48.16 Quite Low
Ectodermal Dysplasia 4 47.68 Quite Low
Adhesions 8 47.16 Quite Low
Apoptosis 9 44.56 Quite Low
Necrosis 4 39.32 Quite Low
INFLAMMATION 4 29.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In MOR-expressing cell lines SH-SY5Y, P19, and PC12, B6 MOR promoter possessed high transcription activity than the CXBK promoter, and Sp1 inhibitor PDTC reduced the promoter activities.
Positive_regulation (possessed) of CXBK promoter in P19 associated with opioid receptor
1) Confidence 0.03 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.62
To determine whether we could observe a similar enhancement of regulation, we modified the original pShuttle-H1-shRNA plasmid containing a single TetO2 (1×-TetO2) with an additional TetO2 operon upstream of the TATA box, forming a 2×-TetO2-H1 promoter.
Positive_regulation (forming) of promoter
2) Confidence 0.01 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.45 Pain Relevance 0
Because regulation is based on repression of a modified active promoter rather than the transactivation of a minimal promoter, the required components are reliably expressed as a single construct.
Positive_regulation (transactivation) of promoter associated with repression
3) Confidence 0.01 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.22 Pain Relevance 0
Because regulation is based on repression of a modified active promoter rather than the transactivation of a minimal promoter, the required components are reliably expressed as a single construct.
Positive_regulation (transactivation) of promoter associated with repression
4) Confidence 0.01 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.22 Pain Relevance 0
CP3 protein repressed about 40% of the Oprm1 proximal promoter activity induced in pcDNA4 vector only-transfected cells (Fig. 5).


Positive_regulation (induced) of promoter in proximal
5) Confidence 0.01 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0 Pain Relevance 0
In MOR-expressing cell lines SH-SY5Y, P19, and PC12, B6 MOR promoter possessed high transcription activity than the CXBK promoter, and Sp1 inhibitor PDTC reduced the promoter activities.
Positive_regulation (possessed) of CXBK promoter in SH-SY5Y associated with opioid receptor
6) Confidence 0.01 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.62
The results of these analyses indicate that over-expression of Foxl2 resulted in a significant increase in GnRHR promoter activity.
Positive_regulation (increase) of promoter
7) Confidence 0.01 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
Foxl2 over-expression resulted in a 6 fold activation of the GnRHR gene promoter in transient co-transfections of KK1 cells.
Positive_regulation (activation) of promoter
8) Confidence 0.01 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
In the regulation of the nicotinic acetylcholine receptor gene, Gabpa recruits the histone acetyl transferase p300 when the promoter is activated, and recruits the histone deacetylase HDAC1 when the promoter is not activated [35].
Positive_regulation (activated) of promoter
9) Confidence 0.01 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.08 Pain Relevance 0
In the regulation of the nicotinic acetylcholine receptor gene, Gabpa recruits the histone acetyl transferase p300 when the promoter is activated, and recruits the histone deacetylase HDAC1 when the promoter is not activated [35].
Neg (not) Positive_regulation (activated) of promoter
10) Confidence 0.01 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox