INT123414

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.20
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp1) intracellular (Sp1) DNA binding (Sp1)
transcription factor binding (Sp1) cytoplasm (Sp1)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 15 100.00 Very High Very High Very High
Morphine 4 98.60 Very High Very High Very High
mu opioid receptor 84 98.48 Very High Very High Very High
Inflammation 20 72.72 Quite High
cINOD 9 68.00 Quite High
metalloproteinase 31 67.96 Quite High
agonist 5 63.32 Quite High
opiate 1 62.96 Quite High
Analgesic 1 55.12 Quite High
analgesia 1 52.48 Quite High
Disease Link Frequency Relevance Heat
Cancer 160 98.68 Very High Very High Very High
Hypoxia 39 90.56 High High
Disease 171 78.32 Quite High
Stress 57 74.08 Quite High
INFLAMMATION 26 72.72 Quite High
Targeted Disruption 66 66.88 Quite High
Death 16 54.24 Quite High
Metastasis 33 50.00 Quite Low
Repression 10 50.00 Quite Low
Severe Combined Immunodeficiency 9 44.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, the A-to-C change at MOR 5'-UTR decreases Sp1 binding and MOR gene transcription, which could underlie the reduced morphine expression in CXBK mice.
Transcription (transcription) of Sp1 associated with opioid receptor and morphine
1) Confidence 0.48 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.62
Our laboratory and others have demonstrated that MOR promoter activity is regulated by many enhancer elements and their related transcriptional factors such as SOX, SP1, AP2, NF-?
Transcription (transcriptional) of SP1 associated with mu opioid receptor
2) Confidence 0.38 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.06 Pain Relevance 0.60
Secondly, we found that THL could inhibit, in cancer cells, the activity of ERK1/2 (Fig 2D), which phosphorylates the transcription factor Sp1 and causes the recruitment of Sp1 to the vegf-A promoter [65].
Transcription (transcription) of Sp1 associated with cancer
3) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 1.23 Pain Relevance 0.03
It also contains a variety of transcription factor binding sites, including those for Sp1, GATA-1, AP1, AP2, CREB, estrogen and glucocorticoid receptors, NF?
Transcription (transcription) of Sp1
4) Confidence 0.23 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.55 Pain Relevance 0
It also contains a variety of transcription factor binding sites, including those for Sp1, GATA-1, AP1, AP2, CREB, estrogen and glucocorticoid receptors, NF?
Transcription (transcription) of Sp1
5) Confidence 0.18 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.36 Pain Relevance 0.14

General Comments

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