INT123419

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 37
Total Number 39
Disease Relevance 7.09
Pain Relevance 26.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NAV1) cytoplasm (NAV1)
Anatomy Link Frequency
nodes 2
plasma 1
glial cell 1
brain 1
vestibule 1
NAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.7 831 100.00 Very High Very High Very High
sodium channel 592 100.00 Very High Very High Very High
nav1.8 178 100.00 Very High Very High Very High
Nav1.1 105 100.00 Very High Very High Very High
nav1.3 76 100.00 Very High Very High Very High
Nav1.6 74 100.00 Very High Very High Very High
Nav1.2 73 100.00 Very High Very High Very High
Nav1.9 43 100.00 Very High Very High Very High
local anesthetic 31 100.00 Very High Very High Very High
Potency 8 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Erythermalgia 99 100.00 Very High Very High Very High
Pain 397 98.88 Very High Very High Very High
Neuropathic Pain 107 98.70 Very High Very High Very High
Neuroblastoma 9 98.12 Very High Very High Very High
Pulpitis 37 96.12 Very High Very High Very High
Hyperalgesia 22 95.40 Very High Very High Very High
Fatigue 51 94.68 High High
Disease 59 92.76 High High
Somatoform Disorder 101 92.44 High High
Inflammatory Pain 25 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We further probed the interaction of mibefradil with inactivated Nav1.5 channels.
Nav1 Binding (interaction) of
1) Confidence 0.48 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562257 Disease Relevance 0 Pain Relevance 0.25
All nodal accumulations were classified as either typical, or atypical and further classified as associated with Nav1.7 or as lacking this association.
Nav1 Binding (associated) of associated with nav1.7
2) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.78
Together, these results identify the increased association of Nav1.7 at both typical and atypical nodal sites and an increased occurrence of atypical nodal forms within painful samples.


Nav1 Binding (association) of associated with pain and nav1.7
3) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.89
The increased incidence of atypical nodal forms seen in our painful samples and the association of Nav1.7 with these atypical nodal forms provides evidence for the remodeling of NaChs at demyelinated sites as a pulpal pain mechanism.
Nav1 Binding (association) of associated with pain and nav1.7
4) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 1.32 Pain Relevance 1.39
Tricyclic antidepressants were potent sodium channel inhibitors and their potency in binding to the inactivated state of Nav1.7 was within the range of plasma concentrations required for the treatment of neuropathic pain.
Nav1 Binding (binding) of in plasma associated with neuropathic pain, sodium channel, nav1.7, tricyclic antidepressant and potency
5) Confidence 0.43 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2346569 Disease Relevance 0.72 Pain Relevance 1.64
Recently [18] Henry and colleagues have reported Nav1.8-immunoreactivity associated with the nodes of Ranvier in the radicular human tooth pulp.
Nav1.8-immunoreactivity Binding (associated) of in tooth pulp associated with nav1.8
6) Confidence 0.42 Published 2005 Journal BMC Oral Health Section Body Doc Link PMC1183220 Disease Relevance 0.19 Pain Relevance 0.69
This evaluation further allowed the characterization of Nav1.7 at some caspr-identified atypical sites that were classified as split nodes where two distinct Nav1.7 accumulations were separated by a gap in the Nav1.7 staining within the same fiber and with each Nav1.7 accumulation being flanked on only one side by caspr.


Nav1 Binding (characterization) of in nodes associated with nav1.7
7) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.76
This evaluation further allowed the characterization of Nav1.7 at some caspr-identified atypical sites that were classified as split nodes where two distinct Nav1.7 accumulations were separated by a gap in the Nav1.7 staining within the same fiber and with each Nav1.7 accumulation being flanked on only one side by caspr.


Nav1 Binding (gap) of in nodes associated with nav1.7
8) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.91
Patients with the paramyotonia I693T Nav1.4 mutation, and those with the erythromelalgia mutation Nav1.7, both show temperature sensitivity; but while cooling of the IEM patients with Nav1.7/I848T mutations relieves pain, it precipitates symptoms in paramyotonia patients carrying the Nav1.4/I693T mutation.
Nav1 Binding (cooling) of associated with pain, erythermalgia and nav1.7
9) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC1781932 Disease Relevance 1.02 Pain Relevance 1.03
Test slides were incubated with a primary polyclonal antibody designed to recognize Nav1.1 (sc-16031, goat), Nav1.2 (sc-28753, rabbit), Nav1.3 (sc-22202, goat), Nav1.4 (sc-28751, rabbit) and Nav1.5 (sc-22758, rabbit), from Santa Cruz Biotechnology (Santa Cruz, CA); Nav1.6 (asc-009, rabbit) from Alomone Labs (Jerusalem, Israel); Nav1.7 (ab-65167, rabbit), Nav1.8 (ab-66743, rabbit), Nav1.9 (ab-65160, rabbit) and Nax (ab-66499, rabbit), from Abcam (Cambridge, UK).
Nav1 Binding (recognize) of associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
10) Confidence 0.36 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.67
Test slides were incubated with a primary polyclonal antibody designed to recognize Nav1.1 (sc-16031, goat), Nav1.2 (sc-28753, rabbit), Nav1.3 (sc-22202, goat), Nav1.4 (sc-28751, rabbit) and Nav1.5 (sc-22758, rabbit), from Santa Cruz Biotechnology (Santa Cruz, CA); Nav1.6 (asc-009, rabbit) from Alomone Labs (Jerusalem, Israel); Nav1.7 (ab-65167, rabbit), Nav1.8 (ab-66743, rabbit), Nav1.9 (ab-65160, rabbit) and Nax (ab-66499, rabbit), from Abcam (Cambridge, UK).
Nav1 Binding (recognize) of associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
11) Confidence 0.36 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.69
Test slides were incubated with a primary polyclonal antibody designed to recognize Nav1.1 (sc-16031, goat), Nav1.2 (sc-28753, rabbit), Nav1.3 (sc-22202, goat), Nav1.4 (sc-28751, rabbit) and Nav1.5 (sc-22758, rabbit), from Santa Cruz Biotechnology (Santa Cruz, CA); Nav1.6 (asc-009, rabbit) from Alomone Labs (Jerusalem, Israel); Nav1.7 (ab-65167, rabbit), Nav1.8 (ab-66743, rabbit), Nav1.9 (ab-65160, rabbit) and Nax (ab-66499, rabbit), from Abcam (Cambridge, UK).
Nav1 Binding (recognize) of associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
12) Confidence 0.36 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.66
Test slides were incubated with a primary polyclonal antibody designed to recognize Nav1.1 (sc-16031, goat), Nav1.2 (sc-28753, rabbit), Nav1.3 (sc-22202, goat), Nav1.4 (sc-28751, rabbit) and Nav1.5 (sc-22758, rabbit), from Santa Cruz Biotechnology (Santa Cruz, CA); Nav1.6 (asc-009, rabbit) from Alomone Labs (Jerusalem, Israel); Nav1.7 (ab-65167, rabbit), Nav1.8 (ab-66743, rabbit), Nav1.9 (ab-65160, rabbit) and Nax (ab-66499, rabbit), from Abcam (Cambridge, UK).
Nav1 Binding (recognize) of associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
13) Confidence 0.36 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.70
Test slides were incubated with a primary polyclonal antibody designed to recognize Nav1.1 (sc-16031, goat), Nav1.2 (sc-28753, rabbit), Nav1.3 (sc-22202, goat), Nav1.4 (sc-28751, rabbit) and Nav1.5 (sc-22758, rabbit), from Santa Cruz Biotechnology (Santa Cruz, CA); Nav1.6 (asc-009, rabbit) from Alomone Labs (Jerusalem, Israel); Nav1.7 (ab-65167, rabbit), Nav1.8 (ab-66743, rabbit), Nav1.9 (ab-65160, rabbit) and Nax (ab-66499, rabbit), from Abcam (Cambridge, UK).
Nav1 Binding (recognize) of associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
14) Confidence 0.36 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.66
Test slides were incubated with a primary polyclonal antibody designed to recognize Nav1.1 (sc-16031, goat), Nav1.2 (sc-28753, rabbit), Nav1.3 (sc-22202, goat), Nav1.4 (sc-28751, rabbit) and Nav1.5 (sc-22758, rabbit), from Santa Cruz Biotechnology (Santa Cruz, CA); Nav1.6 (asc-009, rabbit) from Alomone Labs (Jerusalem, Israel); Nav1.7 (ab-65167, rabbit), Nav1.8 (ab-66743, rabbit), Nav1.9 (ab-65160, rabbit) and Nax (ab-66499, rabbit), from Abcam (Cambridge, UK).
Nav1 Binding (recognize) of associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
15) Confidence 0.36 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.70
Test slides were incubated with a primary polyclonal antibody designed to recognize Nav1.1 (sc-16031, goat), Nav1.2 (sc-28753, rabbit), Nav1.3 (sc-22202, goat), Nav1.4 (sc-28751, rabbit) and Nav1.5 (sc-22758, rabbit), from Santa Cruz Biotechnology (Santa Cruz, CA); Nav1.6 (asc-009, rabbit) from Alomone Labs (Jerusalem, Israel); Nav1.7 (ab-65167, rabbit), Nav1.8 (ab-66743, rabbit), Nav1.9 (ab-65160, rabbit) and Nax (ab-66499, rabbit), from Abcam (Cambridge, UK).
Nav1 Binding (recognize) of associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
16) Confidence 0.36 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.70
Test slides were incubated with a primary polyclonal antibody designed to recognize Nav1.1 (sc-16031, goat), Nav1.2 (sc-28753, rabbit), Nav1.3 (sc-22202, goat), Nav1.4 (sc-28751, rabbit) and Nav1.5 (sc-22758, rabbit), from Santa Cruz Biotechnology (Santa Cruz, CA); Nav1.6 (asc-009, rabbit) from Alomone Labs (Jerusalem, Israel); Nav1.7 (ab-65167, rabbit), Nav1.8 (ab-66743, rabbit), Nav1.9 (ab-65160, rabbit) and Nax (ab-66499, rabbit), from Abcam (Cambridge, UK).
Nav1 Binding (recognize) of associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
17) Confidence 0.36 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.68
Test slides were incubated with a primary polyclonal antibody designed to recognize Nav1.1 (sc-16031, goat), Nav1.2 (sc-28753, rabbit), Nav1.3 (sc-22202, goat), Nav1.4 (sc-28751, rabbit) and Nav1.5 (sc-22758, rabbit), from Santa Cruz Biotechnology (Santa Cruz, CA); Nav1.6 (asc-009, rabbit) from Alomone Labs (Jerusalem, Israel); Nav1.7 (ab-65167, rabbit), Nav1.8 (ab-66743, rabbit), Nav1.9 (ab-65160, rabbit) and Nax (ab-66499, rabbit), from Abcam (Cambridge, UK).
Nav1 Binding (recognize) of associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
18) Confidence 0.36 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.67
In addition, inhibiting the binding of the fast inactivation lid (Nav1.5 ICM + MTSET) did not alter mibefradil block, confirming that the drug does not preferentially interact with the fast-inactivated state.
Nav1 Binding (binding) of
19) Confidence 0.36 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562257 Disease Relevance 0 Pain Relevance 0.22
The most potent, nonselective member of this class of Nav1.7 blockers has been radiolabeled with tritium. [3H]BNZA binds with high affinity to rat brain synaptosomal membranes (Kd = 1.5 nM) and to membranes prepared from HEK293 cells stably transfected with hNav1.5 (Kd = 0.97 nM).
Nav1 Binding (binds) of in brain associated with nav1.7
20) Confidence 0.35 Published 2007 Journal Biochemistry Section Abstract Doc Link 18027973 Disease Relevance 0.35 Pain Relevance 1.20

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