INT123420

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 0.25
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNMA1) transmembrane transport (KCNMA1)
Anatomy Link Frequency
myometrium 2
peripheral nerve 2
KCNMA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.2 1 96.88 Very High Very High Very High
Nav1.7 2 96.08 Very High Very High Very High
antagonist 1 93.60 High High
addiction 4 72.40 Quite High
Dismenorea 8 53.24 Quite High
Pain 16 50.00 Quite Low
sodium channel 9 50.00 Quite Low
Paroxysmal extreme pain disorder 32 43.40 Quite Low
potassium channel 7 23.92 Low Low
dorsal root ganglion 31 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 10 85.00 Quite High
Pre-term Labor 4 64.72 Quite High
Dysmenorrhea 8 53.24 Quite High
Stress 9 51.60 Quite High
Pain 19 50.00 Quite Low
Erythermalgia 31 44.32 Quite Low
Somatoform Disorder 32 43.40 Quite Low
Cancer 26 26.72 Quite Low
Prostate Cancer 22 24.00 Low Low
Ganglion Cysts 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We utilized the RNAi methodology to investigate the selenium response under reduced expression levels of KCNMA1 (the most significant candidate) in PC3 as well as in LNCaP cell lines.
Negative_regulation (reduced) of Gene_expression (expression) of KCNMA1
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.09 Pain Relevance 0
A reduction in expression of the Maxi-K ?
Negative_regulation (reduction) of Gene_expression (expression) of Maxi-K
2) Confidence 0.51 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
The treatment with selenium caused a reduction in the expression of KCNMA1 in PC3 cell lines in comparison to scram cells (untreated with siRNA) (Table 3).
Negative_regulation (reduction) of Gene_expression (expression) of KCNMA1
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.05 Pain Relevance 0
Quantitative real-time PCR indicated a decrease in the expression of the Maxi-K alpha subunit with labour onset.
Negative_regulation (decrease) of Gene_expression (expression) of Maxi-K
4) Confidence 0.38 Published 2004 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC524189 Disease Relevance 0.05 Pain Relevance 0.05
Pharmacological inhibition of Maxi-K channels, by the specific channel blocker iberiotoxin, increases contractile activity in human uterine tissue [5], whereas compounds that promote Maxi-K channel opening, such as NS1619, have a potent relaxant effect on pregnant human myometrium [6].
Negative_regulation (inhibition) of Gene_expression (channels) of Maxi-K in myometrium
5) Confidence 0.37 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0.06 Pain Relevance 0
Maxi-K channels derive their molecular diversity by alternative splicing of their ?
Negative_regulation (derive) of Gene_expression (channels) of Maxi-K
6) Confidence 0.33 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
Using whole-cell voltage clamp, we examined mibefradil block of four Na+ channel isoforms expressed in human embryonic kidney cells: Nav1.5 (cardiac), Nav1.4 (skeletal muscle), Nav1.2 (brain), and Nav1.7 (peripheral nerve).
Spec (examined) Negative_regulation (block) of Gene_expression (expressed) of channel in peripheral nerve associated with nav1.2 and nav1.7
7) Confidence 0.04 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562257 Disease Relevance 0 Pain Relevance 0.28
Based on these findings, we believe that maxi-K channels that are present in caveolae and interact with caveolin would likewise be responsive to the negative effects of estrogen, and that the decrease in channel current expression could account for the more depolarized myometrial membrane and enhanced contractility during labor.
Negative_regulation (decrease) of Gene_expression (expression) of channel
8) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
When compared with WT channels (set as 100%), the protein levels of mutant channels were 85 ± 12% (n = 3, p = 0.526) for P1308L and 123 ± 15% (n = 2, p = 0.352) for V1298F channels (Figure 2B), suggesting that the smaller currents from mutant channels are not caused by reduced channel synthesis in HEK 293 cells.
Negative_regulation (reduced) of Gene_expression (synthesis) of channel
9) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0 Pain Relevance 0

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