INT123422

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 32
Disease Relevance 6.93
Pain Relevance 5.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lmx1b) cell death (Lmx1b) nucleus (Lmx1b)
DNA binding (Lmx1b)
Anatomy Link Frequency
neurons 8
Pet1 4
dorsal 1
embryos 1
adult brain 1
Lmx1b (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 203 100.00 Very High Very High Very High
Cholecystokinin 126 100.00 Very High Very High Very High
midbrain 26 100.00 Very High Very High Very High
Raphe 240 99.68 Very High Very High Very High
medulla 111 98.88 Very High Very High Very High
Neurobehavioral 5 97.36 Very High Very High Very High
Serotonin 81 95.64 Very High Very High Very High
parabrachial 48 94.96 High High
Neurotransmitter 49 94.88 High High
Central nervous system 35 88.88 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 71 99.96 Very High Very High Very High
Nail-patella Syndrome 43 99.92 Very High Very High Very High
Congenital Anomalies 39 98.72 Very High Very High Very High
Eye Malformation 3 96.24 Very High Very High Very High
Glaucoma 84 94.32 High High
Disease 12 91.52 High High
Syndrome 177 91.44 High High
Open-angle Glaucoma 51 84.32 Quite High
Cleidocranial Dysplasia 6 78.92 Quite High
Cataract 30 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To specifically inactivate Lmx1b expression in 5-HTergic neurons in the adult mouse brain, Lmx1bflox/flox mice were crossed with Pet1-CreERT2 mice (see below) and their offspring Pet1-CreERT2; Lmx1bflox/+ mice were then crossed with one another to obtain Pet1-CreERT2; Lmx1bflox/flox (Lmx1b iCKO) mice.
Gene_expression (expression) of Lmx1b in Pet1
1) Confidence 0.78 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0
To test this hypothesis, we used a tamoxifen-inducible Cre-LoxP system [13] to selectively inactivate Lmx1b expression in central 5-HTergic neurons of adult mice.
Gene_expression (expression) of Lmx1b in neurons
2) Confidence 0.78 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.11
Our previous study has shown that Lmx1b is persistently expressed in central 5-HTergic neurons during postnatal development and throughout adulthood suggesting that Lmx1b may be involved in regulating normal expression of 5-HT in adult brain.
Gene_expression (expressed) of Lmx1b in adult brain
3) Confidence 0.78 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.06 Pain Relevance 0.13
Both Lmx1b and Pet1 are expressed in postmitotic 5-HTergic neurons and essential for the differentiation and survival of 5-HTergic neurons during embryonic development [4], [11], [12].
Gene_expression (expressed) of Lmx1b in neurons
4) Confidence 0.78 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.12 Pain Relevance 0.19
Loss of Pet1 in the 5-HTergic neurons leads to a decrease of Tph2 expression but no change in Lmx1b expression.
Gene_expression (expression) of Lmx1b in Pet1
5) Confidence 0.78 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.16 Pain Relevance 0.15
The pattern of Lmx1b expression during the development of the limb, eye and kidney correlates with the NPS phenotype.
Gene_expression (expression) of Lmx1b in kidney associated with nail-patella syndrome
6) Confidence 0.78 Published 2005 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 15562281 Disease Relevance 0.57 Pain Relevance 0.30
To determine whether these findings correlated with the expression of Lmx1b during development, an internal ribosomal entry site-LacZ reporter was inserted into the 3'UTR of the endogenous murine gene.
Gene_expression (expression) of Lmx1b in internal
7) Confidence 0.78 Published 2005 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 15562281 Disease Relevance 0.58 Pain Relevance 0.21
A neurological phenotype in nail patella syndrome (NPS) patients illuminated by studies of murine Lmx1b expression.
Gene_expression (expression) of Lmx1b in patella associated with nail-patella syndrome
8) Confidence 0.78 Published 2005 Journal Eur. J. Hum. Genet. Section Title Doc Link 15562281 Disease Relevance 0.65 Pain Relevance 0.26
The LMX1B gene is also expressed in the trabecular meshwork but abnormalities in this tissue were not analyzed due to the short life span of the knockout mouse.
Gene_expression (expressed) of LMX1B in meshwork associated with targeted disruption and congenital anomalies
9) Confidence 0.77 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 1.56 Pain Relevance 0
The abnormal expression of collagen in homozygous lmx1b knockout mice may explain the split in the glomerular basement membrane in the kidney or the eye abnormalities [18,19] possibly related with glaucoma.
Gene_expression (expression) of lmx1b in basement membrane associated with eye malformation, targeted disruption and glaucoma
10) Confidence 0.77 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 1.20 Pain Relevance 0
The expression of LMX1B in the kidney occurs exclusively in podocytes [18].
Gene_expression (expression) of LMX1B in podocytes
11) Confidence 0.77 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 0.89 Pain Relevance 0
Our previous studies have shown that the flanked Lmx1b allele was deleted in Wnt1-Cre; Lmx1bflox/?
Gene_expression (allele) of Lmx1b
12) Confidence 0.67 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.18
and Pet1-Cre; Lmx1bflox/?
Gene_expression (/) of Lmx1bflox in Pet1
13) Confidence 0.67 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.12
Deleting Lmx1b in the adult brain results in down-regulation of 5-HTergic neuron-associated genes
Gene_expression (Deleting) of Lmx1b in neuron
14) Confidence 0.67 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.10
We next examined 5-HT expression in Lmx1b iCKO mice, and found that intensities of 5-HT immunofluorescence in individual neurons were slightly reduced in the raphe nuclei of Lmx1b iCKO mice compared with wild-type mice (Figure 3A–D).
Gene_expression (expression) of Lmx1b in neurons associated with raphe
15) Confidence 0.67 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.08
Our previous studies have shown that the flanked Lmx1b allele was deleted in Wnt1-Cre; Lmx1bflox/?
Gene_expression (/) of Lmx1bflox
16) Confidence 0.67 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.15
To test whether deleting Lmx1b decreases the number of 5-HTergic neurons or not, which in turn results in the phenotypes mentioned above, we examined the expression of Aadc and Pet1.
Gene_expression (decreases) of Lmx1b in Pet1
17) Confidence 0.67 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.11
Taken together with their rostral position, these data suggest that the group of Runx1-expressing neurons in the dorsolateral rostral hindbrain is located within the LPBS and at least a subset of these neurons likely express CCK but not Lmx1b.


Gene_expression (express) of Lmx1b in neurons associated with cholecystokinin
18) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.33
We therefore compared the expression of ß-gal and Lmx1b in E18.5 Runx1lacZ/+ embryos.
Gene_expression (expression) of Lmx1b in embryos
19) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.11
Furthermore, Pet1 expression in 5-HTergic neurons requires Lmx1b during embryonic development [12], but its expression in the raphe nuclei of Lmx1b iCKO mice showed no difference from wild-type controls (Figure 5Q–T).
Gene_expression (expression) of Lmx1b in neurons associated with raphe
20) Confidence 0.60 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.23

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