INT12344

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 15.53
Pain Relevance 10.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
NK cell 10
T cell 8
lymphocytes 6
cerebral cortex 5
head 4
Il2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 45 100.00 Very High Very High Very High
Eae 120 99.84 Very High Very High Very High
Central grey 22 99.68 Very High Very High Very High
Morphine 109 99.42 Very High Very High Very High
halothane 6 99.02 Very High Very High Very High
depression 39 99.00 Very High Very High Very High
cytokine 116 98.32 Very High Very High Very High
Clonidine 24 98.08 Very High Very High Very High
Inflammation 158 97.28 Very High Very High Very High
opioid receptor 107 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 429 100.00 Very High Very High Very High
Urological Neuroanatomy 32 99.68 Very High Very High Very High
Uveitis 1 99.58 Very High Very High Very High
Injury 164 99.52 Very High Very High Very High
Death 43 99.26 Very High Very High Very High
Multiple Sclerosis 2 99.12 Very High Very High Very High
Depression 42 99.00 Very High Very High Very High
Infection 181 98.96 Very High Very High Very High
Lymphatic System Cancer 2 98.60 Very High Very High Very High
Recurrence 41 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that the environment which had been paired with morphine altered the mitogenic responsiveness of blood and splenic lymphocytes, decreased natural killer cell activity and decreased interleukin-2 production.
Negative_regulation (decreased) of Gene_expression (production) of interleukin-2 in lymphocytes associated with morphine
1) Confidence 0.59 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1644897 Disease Relevance 0 Pain Relevance 0.31
Bilateral microinjection of 10 nmol of morphine in the PAG significantly (p < 0.001) inhibited IL-2 (31%) production by activated splenic lymphocytes compared with that of PAG saline-injected control rats.
Negative_regulation (inhibited) of Gene_expression (production) of IL-2 in lymphocytes associated with central grey and morphine
2) Confidence 0.54 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.44 Pain Relevance 0.70
Inhibition of interleukin-2 production and downregulation of IL-2 and transferrin receptors on rat splenic lymphocytes following PAG morphine administration: a role in natural killer and T cell suppression.
Negative_regulation (Inhibition) of Gene_expression (production) of interleukin-2 in T cell associated with urological neuroanatomy and morphine
3) Confidence 0.54 Published 1999 Journal J. Interferon Cytokine Res. Section Title Doc Link 10433363 Disease Relevance 0.42 Pain Relevance 0.63
These behavioral data are compatible with the data for IL-2 levels, which showed that IL-2 levels in the cerebral cortex of HA OVX rats were significantly decreased by all three dosages of dioscorea, while IL-2 levels in the prefrontal cortex of LA OVX rats were increased by dioscorea at 250 mg/kg/day.
Negative_regulation (decreased) of in prefrontal Gene_expression (levels) of IL-2 in cerebral cortex associated with anxiety disorder and cerebral cortex
4) Confidence 0.43 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.07 Pain Relevance 0.18
The anxiolytic activity of chronic dioscorea treatment correlated with a decrease in IL-2 levels in the cerebral cortex of HA OVX rats.
Negative_regulation (decrease) of Gene_expression (levels) of IL-2 in cerebral cortex associated with anxiety disorder and cerebral cortex
5) Confidence 0.43 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.04 Pain Relevance 0.30
After chronic dioscorea treatment, a decrease in anxiety and IL-2 levels was observed in the HA OVX rats.
Negative_regulation (decrease) of Gene_expression (levels) of IL-2 associated with anxiety disorder
6) Confidence 0.43 Published 2007 Journal Ann Gen Psychiatry Section Abstract Doc Link PMC1971263 Disease Relevance 0.93 Pain Relevance 0.14
In the present study, decreased avoidance of the open arm of the EPM correlated with lowered levels of IL-2 in the cerebral cortex in HA OVX rats treated with dioscorea.
Negative_regulation (lowered) of Gene_expression (levels) of IL-2 in cerebral cortex associated with anxiety disorder and cerebral cortex
7) Confidence 0.42 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.72 Pain Relevance 0.15
Measurement of IL-2 levels
Negative_regulation (Measurement) of Gene_expression (levels) of IL-2
8) Confidence 0.42 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.07 Pain Relevance 0.25
A similar stimulatory (10 microM) and inhibitory (50-500 microM) effect on splenocyte proliferation and IL-2 production was observed in vitro.
Negative_regulation (effect) of Gene_expression (production) of IL-2
9) Confidence 0.42 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11137573 Disease Relevance 0.14 Pain Relevance 0.35
These results suggested that injection of morphine in the PAG suppresses NK and T cell functions by reducing the ability of T cells to produce IL-2 and downregulating the expression of CD25 and CD71 surface activation markers.
Negative_regulation (reducing) of Gene_expression (produce) of IL-2 in T cell associated with central grey and morphine
10) Confidence 0.39 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.45 Pain Relevance 0.66
DMPP dose-dependently suppressed the mitogenic responsiveness of splenic T lymphocytes, splenic NK cell activity, and interleukin-2 (IL-2) and gamma-interferon production by stimulated splenocytes.
Negative_regulation (suppressed) of Gene_expression (production) of IL-2 in NK cell
11) Confidence 0.36 Published 1993 Journal Brain Behav. Immun. Section Abstract Doc Link 8219413 Disease Relevance 0 Pain Relevance 0.36
In animal experiments, GBY showed its inhibition on granuloma formation, adjuvant arthritis in mice, and IL-1 production of abdominal macrophage and IL-2 production of spleen cell in rats.
Negative_regulation (inhibition) of Gene_expression (production) of IL-2 in spleen
12) Confidence 0.33 Published 1999 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 11783210 Disease Relevance 0.07 Pain Relevance 0
Ethanol consumption resulted in a reduction of the production of IL-2, IL-4, and IL-6 as well as the basal and cytokine-activated NK cell cytolytic activity and IFN-gamma production in splenocytes.
Negative_regulation (reduction) of Gene_expression (production) of IL-2 in NK cell associated with cytokine
13) Confidence 0.32 Published 2010 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 19929573 Disease Relevance 0.10 Pain Relevance 0.70
Ethanol consumption resulted in a reduction of the production of IL-2, IL-4, and IL-6 as well as the basal and cytokine-activated NK cell cytolytic activity and IFN-gamma production in splenocytes.
Negative_regulation (resulted) of Gene_expression (production) of IL-2 in NK cell associated with cytokine
14) Confidence 0.32 Published 2010 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 19929573 Disease Relevance 0.10 Pain Relevance 0.70
CTX also reduced the production of TNF-alpha, IL-1, and IL-2 but increased the production of IL-10 and altered pathohistological changes.
Negative_regulation (reduced) of Gene_expression (production) of IL-2
15) Confidence 0.30 Published 2009 Journal Acta Pharmacol. Sin. Section Body Doc Link 19169271 Disease Relevance 0.16 Pain Relevance 0
These results suggest that halothane suppresses rat T cell function, perhaps through suppression of IL-2 receptor expression.
Negative_regulation (suppression) of Gene_expression (expression) of IL-2 in T cell associated with halothane
16) Confidence 0.27 Published 1996 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 8771374 Disease Relevance 0 Pain Relevance 0.48
RESULTS: Intrathecal morphine inhibited splenic NK cell activity, IL-2 production, TNF-beta activity, and increased in serum ACTH level.
Negative_regulation (inhibited) of Gene_expression (production) of IL-2 in NK cell
17) Confidence 0.24 Published 1998 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 10437136 Disease Relevance 0.15 Pain Relevance 0
Thus, an interpretation of our data could be that apoptosis in thermal injury rat CD4+ T cell was due to augmentation of AICD (triggered by Fas ligand) despite a deficiency in IL-2 production by thermal injury rat T cells possibly because of an increased AICD sensitivity to IL-2.
Negative_regulation (deficiency) of Gene_expression (production) of IL-2 in T cell associated with injury, apoptosis and death
18) Confidence 0.22 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 1.63 Pain Relevance 0.08
The mean levels of IL-2 were significantly lowered in Group III than Group I and Group II and the mean levels of TNF-?
Negative_regulation (lowered) of Gene_expression (levels) of IL-2
19) Confidence 0.21 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 0.98 Pain Relevance 0.19
In spite of the transient decrease in antigen-driven IL-2 synthesis, no clinical evidence of infection was noted in any healthy patient.
Negative_regulation (decrease) of Gene_expression (synthesis) of IL-2 associated with infection
20) Confidence 0.15 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 0.65 Pain Relevance 0.32

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