INT12345

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Context Info
Confidence 0.78
First Reported 1987
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 142
Total Number 144
Disease Relevance 59.17
Pain Relevance 51.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
NK cell 16
lymphocyte 13
T cell 13
spleen 6
head 6
Il2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 553 100.00 Very High Very High Very High
cytokine 499 100.00 Very High Very High Very High
nociceptor 2 100.00 Very High Very High Very High
Eae 389 99.92 Very High Very High Very High
substance P 49 99.84 Very High Very High Very High
Kappa opioid receptor 5 99.80 Very High Very High Very High
cerebral cortex 146 99.68 Very High Very High Very High
Locus ceruleus 10 99.60 Very High Very High Very High
Neuritis 18 99.56 Very High Very High Very High
Peripheral nervous system 15 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 685 100.00 Very High Very High Very High
Cancer 129 100.00 Very High Very High Very High
Necrosis 70 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 12 100.00 Very High Very High Very High
Anxiety Disorder 1367 99.90 Very High Very High Very High
Targeted Disruption 38 99.60 Very High Very High Very High
Experimental Autoimmune Neuritis 18 99.56 Very High Very High Very High
Injury 715 99.52 Very High Very High Very High
Primary Sclerosing Cholangitis 6 99.46 Very High Very High Very High
Disease 224 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the high VE diet induced a significant increase in interleukin 2 (IL2) production from splenocytes in both young rats and old rats following in vitro stimulation with Con A for 48 h.
Gene_expression (production) of interleukin 2
1) Confidence 0.78 Published 1997 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 9151245 Disease Relevance 0.07 Pain Relevance 0.05
Furthermore, the high VE diet induced a significant increase in interleukin 2 (IL2) production from splenocytes in both young rats and old rats following in vitro stimulation with Con A for 48 h.
Gene_expression (production) of IL2
2) Confidence 0.78 Published 1997 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 9151245 Disease Relevance 0.07 Pain Relevance 0.05
Compared to the traumatic group, the inhibition of the NK cell activity and the induction of IL-2 production were antagonised by icv injection of naloxone.
Gene_expression (production) of IL-2 in NK cell associated with narcan
3) Confidence 0.78 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11367675 Disease Relevance 0.09 Pain Relevance 0.54
The present study was undertaken to examine the effects of intracerebroventricular (icv) injection of naloxone (an antagonist of opioid receptors) and electroacupuncture (EA) on the natural killer (NK) cell activity, lymphocyte proliferation and induction of interleukin-2 (IL-2) production of spleen lymphocytes of surgically traumatized rats.
Gene_expression (production) of IL-2 in lymphocyte associated with antagonist, narcan, opioid receptor, electroacupuncture and intracerebroventricular
4) Confidence 0.78 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11367675 Disease Relevance 0.06 Pain Relevance 0.46
The present study was undertaken to examine the effects of intracerebroventricular (icv) injection of naloxone (an antagonist of opioid receptors) and electroacupuncture (EA) on the natural killer (NK) cell activity, lymphocyte proliferation and induction of interleukin-2 (IL-2) production of spleen lymphocytes of surgically traumatized rats.
Gene_expression (production) of interleukin-2 in lymphocyte associated with antagonist, narcan, opioid receptor, electroacupuncture and intracerebroventricular
5) Confidence 0.78 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11367675 Disease Relevance 0.06 Pain Relevance 0.46
The NK cell activity, the spleen lymphocyte proliferation and the induction of IL-2 production were all significantly inhibited following traumatization.
Gene_expression (production) of IL-2 in NK cell
6) Confidence 0.78 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11367675 Disease Relevance 0.07 Pain Relevance 0.52
The results showed that the environment which had been paired with morphine altered the mitogenic responsiveness of blood and splenic lymphocytes, decreased natural killer cell activity and decreased interleukin-2 production.
Gene_expression (production) of interleukin-2 in lymphocytes associated with morphine
7) Confidence 0.78 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1644897 Disease Relevance 0 Pain Relevance 0.31
In the present study, decreased avoidance of the open arm of the EPM correlated with lowered levels of IL-2 in the cerebral cortex in HA OVX rats treated with dioscorea.
Gene_expression (levels) of IL-2 in cerebral cortex associated with anxiety disorder and cerebral cortex
8) Confidence 0.77 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.72 Pain Relevance 0.15
The data suggest that dynorphin A enhanced mitogen-stumulated lymphocyte proliferation and IL-2 production via kappa-opioid receptor and cAMP pathway.
Gene_expression (production) of IL-2 in lymphocyte associated with dynorphin and kappa opioid receptor
9) Confidence 0.77 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657483 Disease Relevance 0 Pain Relevance 0.62
Dynorphin A enhances mitogen-induced proliferative response and interleukin-2 production of rat splenocytes.
Gene_expression (production) of interleukin-2 associated with dynorphin
10) Confidence 0.77 Published 1999 Journal Neuropeptides Section Title Doc Link 10657483 Disease Relevance 0 Pain Relevance 0.68
In this study, we investigated dynorphin A in the regulation of mitogen-induced proliferation and and interleukin-2 (IL-2) production of rat splenocytes.
Gene_expression (production) of IL-2 associated with dynorphin
11) Confidence 0.77 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657483 Disease Relevance 0 Pain Relevance 0.63
The results showed that dynorphin A 1-13 as well as dynorphin A 1-17 enhanced concanavalin A-stimulated [(3)H] thymidine uptake 46-112% and IL-2 production in a dose-dependent fashion.
Gene_expression (production) of IL-2 associated with dynorphin
12) Confidence 0.77 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657483 Disease Relevance 0 Pain Relevance 0.65
In this study, we investigated dynorphin A in the regulation of mitogen-induced proliferation and and interleukin-2 (IL-2) production of rat splenocytes.
Gene_expression (production) of interleukin-2 associated with dynorphin
13) Confidence 0.77 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657483 Disease Relevance 0 Pain Relevance 0.63
In this work we found that xylazine administered in vivo at a dose of 2.5 mg/kg enhanced spleen cell proliferation and interleukin 2 (IL-2) production in cultures stimulated with concanavalin A (Con A), whereas doses of 10 and 25 mg/kg were inhibitory.
Gene_expression (production) of interleukin 2 in spleen
14) Confidence 0.77 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11137573 Disease Relevance 0.05 Pain Relevance 0.30
A similar stimulatory (10 microM) and inhibitory (50-500 microM) effect on splenocyte proliferation and IL-2 production was observed in vitro.
Gene_expression (production) of IL-2
15) Confidence 0.77 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11137573 Disease Relevance 0.14 Pain Relevance 0.35
In this work we found that xylazine administered in vivo at a dose of 2.5 mg/kg enhanced spleen cell proliferation and interleukin 2 (IL-2) production in cultures stimulated with concanavalin A (Con A), whereas doses of 10 and 25 mg/kg were inhibitory.
Gene_expression (production) of IL-2 in spleen
16) Confidence 0.77 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11137573 Disease Relevance 0.05 Pain Relevance 0.30
None of these treatments resulted in detectable alterations in IL-2 production after 48 h in culture.
Gene_expression (production) of IL-2
17) Confidence 0.76 Published 1987 Journal Brain Behav. Immun. Section Abstract Doc Link 2967722 Disease Relevance 0 Pain Relevance 0.47
In vivo effects of beta-endorphin on lymphocyte proliferation and interleukin 2 production.
Gene_expression (production) of interleukin 2 in lymphocyte associated with narcan
18) Confidence 0.76 Published 1987 Journal Brain Behav. Immun. Section Title Doc Link 2967722 Disease Relevance 0 Pain Relevance 0.49
Experiments were undertaken in rats to investigate the effects of in vivo infusion of beta-endorphin (BEP) on subsequent Con A-induced proliferation and interleukin 2 (IL-2) production by spleen cells in vitro.
Gene_expression (production) of interleukin 2 in spleen
19) Confidence 0.76 Published 1987 Journal Brain Behav. Immun. Section Abstract Doc Link 2967722 Disease Relevance 0 Pain Relevance 0.29
Experiments were undertaken in rats to investigate the effects of in vivo infusion of beta-endorphin (BEP) on subsequent Con A-induced proliferation and interleukin 2 (IL-2) production by spleen cells in vitro.
Gene_expression (production) of IL-2 in spleen
20) Confidence 0.76 Published 1987 Journal Brain Behav. Immun. Section Abstract Doc Link 2967722 Disease Relevance 0 Pain Relevance 0.29

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