INT123458

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 9
Total Number 15
Disease Relevance 14.30
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf11b) extracellular region (Tnfrsf11b) proteinaceous extracellular matrix (Tnfrsf11b)
extracellular matrix organization (Tnfrsf11b)
Anatomy Link Frequency
bone marrow 2
synovial fluid 1
osteoblast 1
fibroblasts 1
ankle 1
Tnfrsf11b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 68 99.80 Very High Very High Very High
rheumatoid arthritis 100 99.42 Very High Very High Very High
cytokine 42 99.28 Very High Very High Very High
Angina 7 97.96 Very High Very High Very High
Infliximab 96 97.24 Very High Very High Very High
Pain 6 87.68 High High
chemokine 6 22.48 Low Low
antagonist 7 18.84 Low Low
Versed 1 14.84 Low Low
Bile 39 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 8 100.00 Very High Very High Very High
Atherosclerosis 65 99.92 Very High Very High Very High
Calcification 17 99.92 Very High Very High Very High
Osteogenic Sarcomas 5 99.86 Very High Very High Very High
INFLAMMATION 63 99.80 Very High Very High Very High
Breast Cancer 18 99.74 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 3 99.60 Very High Very High Very High
Rheumatoid Arthritis 100 99.42 Very High Very High Very High
Myocardial Infarction 24 98.52 Very High Very High Very High
Stable Angina Pectoris 2 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, the increased RANKL/OPG ratio in metastatic breast cancer results in severe osteolysis.
Positive_regulation (increased) of OPG associated with osteolysis and advanced or metastatic breast cancer
1) Confidence 0.43 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19201081 Disease Relevance 1.34 Pain Relevance 0.09
The present study shows that serum OPG level was not increased in young survivors of uncomplicated myocardial infarction.
Neg (not) Positive_regulation (increased) of OPG associated with myocardial infarction
2) Confidence 0.39 Published 2006 Journal Thromb. Haemost. Section Abstract Doc Link 16676081 Disease Relevance 0.72 Pain Relevance 0.06
Increased serum OPG levels have been reported in patients with stable angina pectoris and survivors of myocardial infarction with heart failure.
Positive_regulation (Increased) of OPG in heart associated with stable angina pectoris, angina and myocardial infarction
3) Confidence 0.39 Published 2006 Journal Thromb. Haemost. Section Abstract Doc Link 16676081 Disease Relevance 0.89 Pain Relevance 0.10
The bioassay is based on the induction of IL-6 and osteoprotegerin (OPG) production by synoviocytes in response to TNF-?.
Positive_regulation (induction) of osteoprotegerin
4) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064892 Disease Relevance 0.79 Pain Relevance 0.33
RA synoviocytes produce higher levels of OPG than do peripheral blood mononuclear cells or synovial fluid mononuclear cells, but they do not produce soluble receptor activator of nuclear factor-?
Positive_regulation (levels) of OPG in synovial fluid associated with rheumatoid arthritis
5) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.48 Pain Relevance 0.36
We have investigated the ability of bone marrow stromal cells (BMSC) isolated from breast cancer patients to generate osteoprotegerin (OPG), a molecule involved both in bone turnover and cell survival.
Spec (investigated) Positive_regulation (generate) of OPG in bone marrow associated with breast cancer
6) Confidence 0.24 Published 2004 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 15567943 Disease Relevance 1.27 Pain Relevance 0.08
We have investigated the ability of bone marrow stromal cells (BMSC) isolated from breast cancer patients to generate osteoprotegerin (OPG), a molecule involved both in bone turnover and cell survival.
Spec (investigated) Positive_regulation (generate) of osteoprotegerin in bone marrow associated with breast cancer
7) Confidence 0.24 Published 2004 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 15567943 Disease Relevance 1.27 Pain Relevance 0.08
As for IL-6, OPG production by synoviocytes increased in a dose-dependent manner in response to TNF-?
Positive_regulation (increased) of OPG
8) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.16 Pain Relevance 0.22
A number of traditional cardiovascular risk factors and increased osteoprotegerin concentrations are associated with abnormal ABIs.
Positive_regulation (increased) of osteoprotegerin
9) Confidence 0.14 Published 2010 Journal J Int AIDS Soc Section Abstract Doc Link PMC2859852 Disease Relevance 1.01 Pain Relevance 0
Elevated levels of osteoprotegerin, an inflammatory cytokine receptor, have been associated with a high incidence of cardiovascular disease (including peripheral arterial disease, or PAD), acute coronary syndrome, and cardiovascular mortality.
Positive_regulation (levels) of osteoprotegerin associated with acute coronary syndrome, inflammation, cardiovascular disease, peripheral arterial disease and cytokine
10) Confidence 0.14 Published 2010 Journal J Int AIDS Soc Section Abstract Doc Link PMC2859852 Disease Relevance 1.09 Pain Relevance 0.10
Elevated levels of osteoprotegerin, an inflammatory cytokine receptor, have been associated with a high incidence of cardiovascular disease (including peripheral arterial disease, or PAD), acute coronary syndrome, and cardiovascular mortality.
Positive_regulation (Elevated) of osteoprotegerin associated with acute coronary syndrome, inflammation, cardiovascular disease, peripheral arterial disease and cytokine
11) Confidence 0.14 Published 2010 Journal J Int AIDS Soc Section Abstract Doc Link PMC2859852 Disease Relevance 1.10 Pain Relevance 0.10
Compared with patients with normal ABIs, patients with high ABIs had significantly elevated levels of osteoprotegerin [1428.9 (713.1) pg/ml vs. 3088.6 (3565.9) pg/ml, respectively, p = 0.03].


Positive_regulation (elevated) of osteoprotegerin
12) Confidence 0.12 Published 2010 Journal J Int AIDS Soc Section Abstract Doc Link PMC2859852 Disease Relevance 1.37 Pain Relevance 0.05
Elevated osteoprotegerin is associated with abnormal ankle brachial indices in patients infected with HIV: a cross-sectional study

Background

Positive_regulation (Elevated) of osteoprotegerin in ankle associated with acquired immune deficiency syndrome or hiv infection
13) Confidence 0.12 Published 2010 Journal J Int AIDS Soc Section Title Doc Link PMC2859852 Disease Relevance 1.37 Pain Relevance 0.09
Different from BM-MSCs, dermal fibroblasts were found to release high levels of IL6 and osteoprotegerin in this study.
Positive_regulation (levels) of osteoprotegerin in fibroblasts
14) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270908 Disease Relevance 0.74 Pain Relevance 0.34
Vitamin K2 treatment of osteosarcoma cells increased mRNA levels for the osteoblast markers bone alkaline phosphatase, osteoprotegerin, osteopontin and matrix Gla protein.
Positive_regulation (increased) of osteoprotegerin in osteoblast associated with osteoporosis and osteogenic sarcomas
15) Confidence 0.07 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.69 Pain Relevance 0

General Comments

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