INT123459

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 37
Disease Relevance 24.16
Pain Relevance 7.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf11b) extracellular region (Tnfrsf11b) proteinaceous extracellular matrix (Tnfrsf11b)
extracellular matrix organization (Tnfrsf11b)
Anatomy Link Frequency
stromal cells 4
osteoblasts 3
artery 2
osteoclasts 2
plasma 1
Tnfrsf11b (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 810 99.84 Very High Very High Very High
Infliximab 548 99.78 Very High Very High Very High
antagonist 23 99.60 Very High Very High Very High
methotrexate 21 97.66 Very High Very High Very High
cytokine 171 94.80 High High
Inflammation 186 94.24 High High
Pain 43 90.20 High High
cINOD 12 81.60 Quite High
Angina 2 80.56 Quite High
Potency 2 75.60 Quite High
Disease Link Frequency Relevance Heat
Calcification 109 100.00 Very High Very High Very High
Cancer 225 99.86 Very High Very High Very High
Rheumatoid Arthritis 810 99.84 Very High Very High Very High
Breast Cancer 57 99.80 Very High Very High Very High
Osteoporosis 56 99.68 Very High Very High Very High
Apoptosis 49 98.94 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 55 98.68 Very High Very High Very High
Reprotox - General 1 1 98.52 Very High Very High Very High
Arthritis 58 98.32 Very High Very High Very High
Targeted Disruption 42 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OPG protects prostate cancer cells from apoptotic effects of TRAIL and therefore provides tumor cells producing OPG with survival advantages.
Gene_expression (producing) of OPG associated with cancer, apoptosis and reprotox - general 1
1) Confidence 0.58 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19201081 Disease Relevance 1.34 Pain Relevance 0.08
Osteoprotegerin acts as a decoy receptor, binding with osteoprotegerin ligand (the natural stimulator of osteoclast maturation) produced by the osteoblast [22].
Gene_expression (produced) of osteoprotegerin in osteoblast associated with osteoporosis
2) Confidence 0.58 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138712 Disease Relevance 0.96 Pain Relevance 0.09
Levels of IL-6 and OPG were measured in supernatants.
Gene_expression (Levels) of OPG
3) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064892 Disease Relevance 0.76 Pain Relevance 0.33
induced IL-6 and OPG production by synoviocytes, which was further increased with patient plasma dilutions and inhibited by infliximab.
Gene_expression (production) of OPG in plasma associated with infliximab
4) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064892 Disease Relevance 0.69 Pain Relevance 0.35
Therefore, a bioassay was developed using the properties of synoviocytes to produce IL-6 and osteoprotegerin (OPG) in response to TNF-?
Gene_expression (produce) of osteoprotegerin
5) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.54 Pain Relevance 0.33
Therefore, a bioassay was developed using the properties of synoviocytes to produce IL-6 and osteoprotegerin (OPG) in response to TNF-?
Gene_expression (produce) of OPG
6) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.54 Pain Relevance 0.34
Serum OPG levels were similar in cases (2.41 ng/ml, 2.11-2.77 ng/ml) (mean, 95% CI) and controls (2.43 ng/ml, 2.11-2.79 ng/ml) (p = 0.92).
Gene_expression (levels) of OPG
7) Confidence 0.50 Published 2006 Journal Thromb. Haemost. Section Abstract Doc Link 16676081 Disease Relevance 0.86 Pain Relevance 0.08
Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosis.
Gene_expression (produced) of OPG in stromal cells associated with breast cancer and apoptosis
8) Confidence 0.46 Published 2004 Journal Breast Cancer Res. Treat. Section Title Doc Link 15567943 Disease Relevance 1.18 Pain Relevance 0.09
Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosis.
Gene_expression (produced) of Osteoprotegerin in stromal cells associated with breast cancer and apoptosis
9) Confidence 0.46 Published 2004 Journal Breast Cancer Res. Treat. Section Title Doc Link 15567943 Disease Relevance 1.18 Pain Relevance 0.09
Similar findings were obtained for OPG production (7.0 ± 6.2 ng/ml versus 0.0 ± 3.0 ng/ml; P < 0.05).
Gene_expression (production) of OPG
10) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064892 Disease Relevance 0.34 Pain Relevance 0.21
Accordingly, we focused on OPG, which is produced in response to TNF-?.
Gene_expression (produced) of OPG
11) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.46 Pain Relevance 0.35
Similar studies were performed for OPG production.
Gene_expression (production) of OPG
12) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.16 Pain Relevance 0.21
With regard to IL-6, addition of infliximab inhibited OPG production induced by TNF-?
Gene_expression (production) of OPG associated with infliximab
13) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.22 Pain Relevance 0.27
The bioassay is based on the induction of IL-6 and osteoprotegerin (OPG) production by synoviocytes in response to TNF-?.
Gene_expression (production) of OPG
14) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064892 Disease Relevance 0.78 Pain Relevance 0.33
RA synoviocytes produce higher levels of OPG than do peripheral blood mononuclear cells or synovial fluid mononuclear cells, but they do not produce soluble receptor activator of nuclear factor-?
Gene_expression (produce) of OPG in synovial fluid associated with rheumatoid arthritis
15) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.49 Pain Relevance 0.36
As for IL-6, OPG production by synoviocytes increased in a dose-dependent manner in response to TNF-?
Gene_expression (production) of OPG
16) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.16 Pain Relevance 0.21
Similar results were observed for IL-6 and OPG production, although changes in IL-6 levels appeared more sensitive.
Gene_expression (production) of OPG
17) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.45 Pain Relevance 0.34
activity was designed using the ability of RA synoviocytes to produce IL-6 and OPG in response to TNF-?
Gene_expression (produce) of OPG associated with rheumatoid arthritis
18) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.73 Pain Relevance 0.43
IL-6 and OPG production were measured by ELISA in 48-hour supernatants, as previously described [5,6].
Gene_expression (production) of OPG
19) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.50 Pain Relevance 0.30
to induce IL-6 and OPG production by RA synoviocytes.
Gene_expression (production) of OPG associated with rheumatoid arthritis
20) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.21 Pain Relevance 0.24

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