INT123466

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 24
Disease Relevance 34.87
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plaque 2
heart 1
body 1
T2dm2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 53 100.00 Very High Very High Very High
cytokine 31 99.90 Very High Very High Very High
imagery 416 99.80 Very High Very High Very High
Inflammatory mediators 16 98.96 Very High Very High Very High
Inflammation 247 98.86 Very High Very High Very High
agonist 15 97.20 Very High Very High Very High
diabetic neuropathy 9 94.00 High High
metalloproteinase 112 86.36 High High
cva 64 81.76 Quite High
rheumatoid arthritis 22 81.20 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1940 100.00 Very High Very High Very High
Insulin Resistance 420 100.00 Very High Very High Very High
Metabolic Syndrome 406 100.00 Very High Very High Very High
Prediabetic State 290 100.00 Very High Very High Very High
Pancreatitis 89 100.00 Very High Very High Very High
Coronary Artery Disease 88 100.00 Very High Very High Very High
Impaired Glucose Tolerance 58 100.00 Very High Very High Very High
Hyperglycemia 82 99.98 Very High Very High Very High
Neuropathy 58 99.98 Very High Very High Very High
Stress 560 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since association between DM 2 and high-risk plaque features might be more prevalent in advanced atherosclerotic diseases [18], this might be a further reason for the differences in our results.
DM 2 Spec (might) Binding (association) of in plaque associated with atherosclerosis, diabetes mellitus and disease
1) Confidence 0.37 Published 2010 Journal BMC Med Imaging Section Body Doc Link PMC3004802 Disease Relevance 1.11 Pain Relevance 0.34
Since in our study regression analysis revealed DM 2 to be associated with high risk lesion types and postprocedural DWI lesions independent of the degree of stenosis, our results suggest that DM seems to play a role in the development of high-risk, rupture prone plaques irrespective of the degree of vessel narrowing.
DM 2 Binding (associated) of in plaques associated with pathologic constriction, rupture, diabetes mellitus and imagery
2) Confidence 0.32 Published 2010 Journal BMC Med Imaging Section Body Doc Link PMC3004802 Disease Relevance 1.10 Pain Relevance 0.25
Multiple logistic regression analysis revealed association between DM 2 and MRI-defined high-risk lesion types (OR 2.59; 95% CI [1.15-5.81]), independent of the degree of stenosis.


DM 2 Binding (association) of associated with pathologic constriction and imagery
3) Confidence 0.24 Published 2010 Journal BMC Med Imaging Section Abstract Doc Link PMC3004802 Disease Relevance 0.66 Pain Relevance 0.44
Multiple logistic regression analysis including DM 2, symptomatic stenosis, degreee of stenosis, cholesterol level, hypertension, smoking status, coronary heart disease, and atrial fibrillation as influencing variables revealed association between DM 2 and MRI-defined high-risk lesion types (OR 2.59; 95% CI [1.15-5.81]) and between symptomatic stenosis and MRI-defined high-risk lesion types (OR 13.38; 95%CI [5.64-31.78]).
DM 2 Binding (association) of in heart associated with coronary artery disease, nicotine addiction, pathologic constriction, diabetes mellitus, hypertension, arrhythmias 2 under development and imagery
4) Confidence 0.24 Published 2010 Journal BMC Med Imaging Section Body Doc Link PMC3004802 Disease Relevance 1.17 Pain Relevance 0.23
Men in the cohort who reported a family history of diabetes, showed a robust association with current T2DM status.
T2DM Binding (association) of associated with diabetes mellitus
5) Confidence 0.17 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2531108 Disease Relevance 1.98 Pain Relevance 0
There is also considerable evidence that supports the inverse association between income and T2DM, particularly in elderly men [54,55], as has been reported by others in both men and women in the same geographic region [56].
T2DM Binding (association) of associated with diabetes mellitus
6) Confidence 0.13 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2531108 Disease Relevance 0.89 Pain Relevance 0.08
Approximately two-thirds of US adult men and women diagnosed with T2DM have a body mass index (BMI) of 27?
T2DM Binding (diagnosed) of in body associated with diabetes mellitus and obesity
7) Confidence 0.06 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2948903 Disease Relevance 1.89 Pain Relevance 0.03
Nevertheless, the SHIELD survey shows clear benefits of exercise, as quality-of-life measures were higher in both the T2DM and no diabetes groups who reported participating in a regular exercise regimen for this period.
T2DM Binding (higher) of associated with diabetes mellitus
8) Confidence 0.06 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2948903 Disease Relevance 0.84 Pain Relevance 0
When considering testing in people with T2DM, it is important to understand the global impact on mechanosensitivity due to the common distal symmetrical polyneuropathy associated with T2DM.
T2DM Binding (associated) of associated with neuropathy and diabetes mellitus
9) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2940775 Disease Relevance 0.85 Pain Relevance 0
Metabolic syndrome and T2DM are associated with multiple metabolic toxicities.
T2DM Binding (associated) of associated with diabetes mellitus and metabolic syndrome
10) Confidence 0.01 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15567993 Disease Relevance 1.34 Pain Relevance 0.17
Endothelial dysfunction is strongly associated with both T1DM and T2DM.
T2DM Binding (associated) of associated with diabetes mellitus
11) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.37 Pain Relevance 0
This reductive stress is dependent upon hyperglycemia associated with both T1DM and T2DM.
T2DM Binding (associated) of associated with hyperglycemia, stress and diabetes mellitus
12) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.29 Pain Relevance 0
Throughout this review, we have tried to remain focused on the relationship between redox stress and ROS in the intima and at times the islet, and how these two interact with the multiplicative effect of the A-FLIGHT toxicities of MS, IR, PD, and overt T2DM to induce atheroscleropathy.
T2DM Binding (interact) of associated with stress, diabetes mellitus, prediabetic state, metabolic syndrome and insulin resistance
13) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 2.36 Pain Relevance 0.30
Lipotoxicity is also associated with MS, IR, PD, and T2DM.
T2DM Binding (associated) of associated with diabetes mellitus, prediabetic state, metabolic syndrome and insulin resistance
14) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.56 Pain Relevance 0.04
This review will focus primarily on the association of redox stress in the intima and how it interacts with MS, IR, PD, and T2DM.


T2DM Binding (interacts) of associated with stress, diabetes mellitus, prediabetic state, metabolic syndrome and insulin resistance
15) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 3.26 Pain Relevance 0
Lipotoxicity promotes oxidative stress and is associated with MS, IR, PD, and T2DM.
T2DM Binding (associated) of associated with stress, diabetes mellitus, prediabetic state, metabolic syndrome and insulin resistance
16) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.16 Pain Relevance 0.03
Inflammation toxicity (with increased redox stress and cytokines) is associated with MS, IR, PD, and early as well as late T2DM.
T2DM Binding (associated) of associated with stress, toxicity, inflammation, diabetes mellitus, prediabetic state, metabolic syndrome, insulin resistance and cytokine
17) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 2.11 Pain Relevance 0.49
In this review, we will try to remain focused on intimal redox stress and how this interacts with the manifold toxicities of IR, MS, PD, and T2DM to result in a unique accelerated atherosclerosis which shall be called atheroscleropathy.


T2DM Binding (interacts) of associated with stress, atherosclerosis, diabetes mellitus, prediabetic state, metabolic syndrome and insulin resistance
18) Confidence 0.01 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.81 Pain Relevance 0
There are conflicting reports in the extent of its association with IHD among subjects with Type 2 diabetes mellitus (T2DM).
T2DM Binding (association) of associated with coronary artery disease and diabetes mellitus
19) Confidence 0.01 Published 2007 Journal Lipids Health Dis Section Abstract Doc Link PMC2216007 Disease Relevance 1.24 Pain Relevance 0
They found a significant association between -948C > A and T2DM (p = 0.021).
T2DM Binding (association) of associated with diabetes mellitus
20) Confidence 0.01 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2857825 Disease Relevance 1.09 Pain Relevance 0.03

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