INT12347

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Context Info
Confidence 0.11
First Reported 1991
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.52
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lateral 1
medial 1
striatum 1
Rent1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Substantia nigra 4 97.36 Very High Very High Very High
Endogenous opioid 1 95.08 Very High Very High Very High
Intracerebroventricular 1 88.00 High High
Morphine 6 82.96 Quite High
tolerance 1 80.72 Quite High
addiction 1 79.60 Quite High
substance P 2 78.52 Quite High
withdrawal 1 75.00 Quite High
medulla 1 75.00 Quite High
Thalamus 1 70.80 Quite High
Disease Link Frequency Relevance Heat
Infection 2 99.42 Very High Very High Very High
Virus Diseases 2 99.22 Very High Very High Very High
Borna Disease 2 99.10 Very High Very High Very High
Dyskinesias 1 84.64 Quite High
Neuroblastoma 1 58.96 Quite High
Disease 2 40.48 Quite Low
Cognitive Disorder 1 37.92 Quite Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Urethane anaesthesia alone resulted in a significant increase in both CRH and proenkephalin transcripts.
Positive_regulation (increase) of transcripts
1) Confidence 0.11 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1645431 Disease Relevance 0 Pain Relevance 0.43
We show that Borna disease virus infection of adult rats results in an increase in preproenkephalin transcripts in the striatum of Borna-infected rats, a region important for forming coordinated sequential motor actions and in developing programmes of thought and motivation.
Positive_regulation (increase) of transcripts in striatum associated with virus diseases, borna disease and infection
2) Confidence 0.09 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12431235 Disease Relevance 0.52 Pain Relevance 0.18
Differences in initiated and mature transcripts are consistent with at least four mechanisms involved in control of cholinergic-induced ppENK RNA expression: (i) simply new initiation of RNA transcripts, (ii) differential usage of the multiple RNA start sites, (iii) stabilization of mRNA transcripts, and (iv) attenuation and/or alternative RNA splicing of RNA transcripts.
Positive_regulation (stabilization) of transcripts
3) Confidence 0.05 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8479282 Disease Relevance 0 Pain Relevance 0.09
However, we found a significant increase in levels of CB1 receptor-mRNA transcripts, measured by in situ hybridization, in the lesioned side in both the lateral and medial caudate-putamen.
Positive_regulation (increase) of transcripts in medial
4) Confidence 0.04 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.15
However, we found a significant increase in levels of CB1 receptor-mRNA transcripts, measured by in situ hybridization, in the lesioned side in both the lateral and medial caudate-putamen.
Positive_regulation (increase) of transcripts in lateral
5) Confidence 0.01 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.15

General Comments

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