INT123501

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Context Info
Confidence 0.12
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.04
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
THP-1 2
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 28 98.84 Very High Very High Very High
cytokine 10 93.04 High High
chemokine 3 91.76 High High
cINOD 4 83.20 Quite High
Inflammatory response 2 76.20 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Abeta 1 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 30 98.84 Very High Very High Very High
Alzheimer's Dementia 21 97.44 Very High Very High Very High
Disease 57 90.92 High High
Gliosis 1 70.48 Quite High
Cancer 2 56.96 Quite High
Necrosis 1 56.48 Quite High
Apoptosis 1 38.72 Quite Low
Glioma 1 30.04 Quite Low
Amyloid Plaque 8 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that curcumin (12.5-25 microm) suppresses the activation of Egr-1 DNA-binding activity in THP-1 monocytic cells.
Negative_regulation (suppresses) of Egr-1 Binding (binding) of in THP-1
1) Confidence 0.12 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.76 Pain Relevance 0.41
By inhibition of Egr-1 DNA-binding activity by curcumin, it reduces the inflammation.
Negative_regulation (inhibition) of Egr-1 Binding (activity) of associated with inflammation
2) Confidence 0.05 Published 2008 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2781139 Disease Relevance 1.27 Pain Relevance 0.58

General Comments

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