INT123502

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.70
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
THP-1 3
neuronal 1
finger 1
dorsal horn 1
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 99.12 Very High Very High Very High
Inflammation 95 98.84 Very High Very High Very High
Dorsal horn 86 98.56 Very High Very High Very High
cytokine 25 93.76 High High
Spinal cord 78 92.76 High High
chemokine 8 91.76 High High
cINOD 12 89.76 High High
long-term potentiation 25 88.80 High High
Neuropeptide 10 80.24 Quite High
IPN 10 79.16 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 151 100.00 Very High Very High Very High
INFLAMMATION 98 98.84 Very High Very High Very High
Disease 120 97.48 Very High Very High Very High
Alzheimer's Dementia 44 96.88 Very High Very High Very High
Apoptosis 7 92.20 High High
Hepatocellular Cancer 4 90.88 High High
Targeted Disruption 10 82.24 Quite High
Inflammatory Pain 10 79.16 Quite High
Gliosis 2 77.04 Quite High
Cognitive Disorder 36 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We confirmed the enriched expression of the following genes: a transcription factor NGFI-A, a putative four repeat ion channel, a vesicle associated calcium/calmodulin binding protein that is homologous to CAMK IV, a neuronal calcium sensor protein hippocalcin, synuclein beta, and an EST gene.
NGFI-A Binding (associated) of in neuronal
1) Confidence 0.35 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC126259 Disease Relevance 0 Pain Relevance 0.31
Zif268, a zinc-finger transcription factor of the Egr family, is implicated in
Zif268 Binding (implicated) of in finger
2) Confidence 0.32 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.58 Pain Relevance 0.19
In contrast to Arc and Zif268, no
Zif268 Binding (contrast) of associated with aids-related complex
3) Confidence 0.32 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.55 Pain Relevance 0
Network analysis was conducted using the set of confirmed mPFC gene expression changes, and revealed that Cart, NPY, Nr4a1, Fos, Egr1, Adora2b and Drd5 all interact (directly or indirectly) with the MAPK/ERK pathway.
Egr1 Binding (interact) of
4) Confidence 0.25 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.08 Pain Relevance 0.25
However, it is well accepted that MeCP2 activity is extremely cell type specific and therefore we cannot exclude a possible direct interaction between MeCP2 and Fos or/and Zif268 promoter region within superficial dorsal horn neurones.
Zif268 Neg (cannot) Binding (interaction) of in dorsal horn associated with dorsal horn
5) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.26 Pain Relevance 0.45
P-MeCP2 is co-expressed in neurones with Zif268 and Fos
Zif268 Binding (neurones) of
6) Confidence 0.12 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.07
This was confirmed by increased NAG-1 promoter activity preceded by the elevation of Egr-1/ DNA binding activity.
Egr-1 Binding (activity) of
7) Confidence 0.10 Published 2009 Journal Int. J. Mol. Med. Section Abstract Doc Link 19724899 Disease Relevance 0.82 Pain Relevance 0.22
This involved abrogation of Egr-1 DNA binding in the promoter of CCR5 by curcumin as determined by: (i) electrophoretic mobility shift assay, (ii) transfection studies with truncated CCR5 gene promoter constructs, and (iii) chromatin immunoprecipitation analysis.
Egr-1 Spec (determined) Binding (binding) of
8) Confidence 0.10 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.47 Pain Relevance 0.35
We show that curcumin (12.5-25 microm) suppresses the activation of Egr-1 DNA-binding activity in THP-1 monocytic cells.
Egr-1 Binding (activity) of in THP-1
9) Confidence 0.10 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.75 Pain Relevance 0.41
We show that curcumin (12.5-25 microm) suppresses the activation of Egr-1 DNA-binding activity in THP-1 monocytic cells.
Egr-1 Binding (binding) of in THP-1
10) Confidence 0.10 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.75 Pain Relevance 0.41
-induced expression of Egr-1 protein and Egr-1 DNA-binding activity in THP-1 monocytic cells.
Egr-1 Binding (activity) of in THP-1
11) Confidence 0.04 Published 2008 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2781139 Disease Relevance 1.16 Pain Relevance 0.54
By inhibition of Egr-1 DNA-binding activity by curcumin, it reduces the inflammation.
Egr-1 Binding (activity) of associated with inflammation
12) Confidence 0.04 Published 2008 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2781139 Disease Relevance 1.27 Pain Relevance 0.57

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