INT123503

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Context Info
Confidence 0.13
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.34
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
THP-1 4
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 8 94.36 High High
cytokine 10 93.76 High High
chemokine 4 90.64 High High
Inflammatory response 2 75.60 Quite High
cINOD 5 75.16 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 12 94.36 High High
Apoptosis 5 92.72 High High
Hepatocellular Cancer 4 90.88 High High
Disease 10 79.12 Quite High
Alzheimer's Dementia 4 77.60 Quite High
Cancer 1 61.48 Quite High
Liver Cancer 1 55.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that curcumin (12.5-25 microm) suppresses the activation of Egr-1 DNA-binding activity in THP-1 monocytic cells.
Positive_regulation (activation) of Egr-1 Binding (binding) of in THP-1
1) Confidence 0.13 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.76 Pain Relevance 0.41
We show that curcumin (12.5-25 microm) suppresses the activation of Egr-1 DNA-binding activity in THP-1 monocytic cells.
Positive_regulation (activation) of Egr-1 Binding (activity) of in THP-1
2) Confidence 0.13 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.76 Pain Relevance 0.41
This was confirmed by increased NAG-1 promoter activity preceded by the elevation of Egr-1/ DNA binding activity.
Positive_regulation (elevation) of Egr-1 Binding (activity) of
3) Confidence 0.10 Published 2009 Journal Int. J. Mol. Med. Section Abstract Doc Link 19724899 Disease Relevance 0.83 Pain Relevance 0.23

General Comments

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