INT123520

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 6.98
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ar) nucleus (Ar) enzyme binding (Ar)
DNA binding (Ar) transcription factor binding (Ar) cytoplasm (Ar)
Anatomy Link Frequency
epithelial cells 2
lacrimal gland 1
meibomian gland 1
lacrimal 1
Ar (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 37 99.96 Very High Very High Very High
withdrawal 12 79.28 Quite High
chemokine 35 79.16 Quite High
cINOD 10 50.00 Quite Low
cytokine 9 23.48 Low Low
Cholecystokinin 4 22.72 Low Low
metalloproteinase 8 20.48 Low Low
Inflammation 35 5.00 Very Low Very Low Very Low
palliative 10 5.00 Very Low Very Low Very Low
dexamethasone 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 470 99.86 Very High Very High Very High
Disorders Of The Lacrimal System 340 99.68 Very High Very High Very High
Carcinoma 4 98.86 Very High Very High Very High
Stress 7 96.00 Very High Very High Very High
Metastasis 24 94.16 High High
Prostate Cancer 38 91.20 High High
Eyelid Disease 8 90.12 High High
Reprotox - General 1 206 86.64 High High
Disease 15 77.08 Quite High
Toxicity 5 69.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The majority of resistant tumors still expresses a functional androgen receptor (AR), frequently amplified or mutated.


Gene_expression (expresses) of androgen receptor associated with cancer
1) Confidence 0.32 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1994591 Disease Relevance 0.74 Pain Relevance 0.05
Our results demonstrate that carcinomas resistant to hormonal manipulations still depend on the expression of the androgen receptor for their development in vivo.
Gene_expression (expression) of androgen receptor associated with carcinoma
2) Confidence 0.25 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1994591 Disease Relevance 0.79 Pain Relevance 0.03
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Gene_expression (expression) of androgen receptor
3) Confidence 0.18 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
It was clearly evident from Western blot analysis of the total protein lysate derived from the dorsolateral prostate tissues with PIN lesions that expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, and BclII is down-regulated more effectively by celecoxib.
Gene_expression (expression) of androgen receptor
4) Confidence 0.18 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0 Pain Relevance 0
Immunofluorescence staining suggested BMDCs in the prostate coexpressed androgen receptor; p63, a basal epithelial marker; and cytokeratin 8, a luminal epithelial marker.
Gene_expression (coexpressed) of androgen receptor
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2944821 Disease Relevance 0.76 Pain Relevance 0.04
We found that co-expression of GFP with androgen receptor indicated the prostate cell lineage of stromal or epithelial cells (Figure 2A).
Gene_expression (expression) of androgen receptor in epithelial cells
6) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944821 Disease Relevance 0 Pain Relevance 0
We found that co-expression of GFP with androgen receptor indicated the prostate cell lineage of stromal or epithelial cells (Figure 2A).
Gene_expression (-) of androgen receptor in epithelial cells
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944821 Disease Relevance 0 Pain Relevance 0
The 4 exceptions were genes that were significantly reduced (ratios between 2.5 to 3.6 fold) by testosterone in female mice, but were not lower following androgen exposure in male lacrimal tissues (Table 11).
Gene_expression (exposure) of androgen in lacrimal associated with disorders of the lacrimal system
8) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.78 Pain Relevance 0
Of the many androgen actions on gene expression in the lacrimal and meibomian glands, two that stand out are the stimulation of meibomian gland genes associated with lipid metabolic pathways, and the suppression of genes related to keratinization.
Gene_expression (expression) of androgen in meibomian gland associated with disorders of the lacrimal system
9) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.90 Pain Relevance 0
The influence of androgen exposure was particularly notable in its significant stimulation of such ontologies as cell cycle, transferase activity and chromosomes in the lacrimal gland (Table 4), and protein transport, oxidoreductase activity and mitochondria in the meibomian gland (Table 5).
Gene_expression (exposure) of androgen in lacrimal gland associated with disorders of the lacrimal system
10) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.84 Pain Relevance 0
Of particular interest was the significant androgen impact on the expression of genes linked to multiple lipid metabolic processes (e.g. biosynthesis, transport, oxidation) in meibomian tissue (Table 6).
Gene_expression (expression) of androgen
11) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.83 Pain Relevance 0
The DHT-triggered stimulation of SphK1 activity was also completely inhibited in presence of androgen receptor antagonist (Fig. 5B).


Gene_expression (presence) of androgen receptor associated with antagonist
12) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0.13
The observed SphK1 inhibition was not relying on de novo synthesis of ceramide (data not shown), which has been previously reported to accumulate following androgen ablation in LNCaP cells [48].
Gene_expression (ablation) of androgen
13) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.61 Pain Relevance 0
The short-term efficacy of androgen depletion was confirmed in vivo using an orthotopic model of xenotransplanted LNCaP cells where castration could not only noticeably reduce tumor size and metastasis dissemination but also induce a significant SphK1 inhibition.
Gene_expression (depletion) of androgen associated with cancer and metastasis
14) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0.67 Pain Relevance 0

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