INT123521

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Context Info
Confidence 0.81
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.00
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
intracellular (Bcl2) cytoplasm (Bcl2) cell proliferation (Bcl2)
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 5 50.00 Quite Low
potassium channel 76 5.00 Very Low Very Low Very Low
Kinase C 38 5.00 Very Low Very Low Very Low
analgesia 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
action potential duration 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 101 100.00 Very High Very High Very High
Starvation 8 98.88 Very High Very High Very High
Cancer 196 97.92 Very High Very High Very High
Death 26 89.60 High High
Breast Cancer 21 88.96 High High
Stress 23 84.64 Quite High
Pancreatic Cancer 64 82.80 Quite High
Cv Unclassified Under Development 68 79.08 Quite High
Dna Damage 1 79.04 Quite High
Congenital Anomalies 10 72.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several studies indicate that in vitro treatment with taxanes induces phosphorylation and inactivation of the Bcl-2 protein as well as apoptosis [27], which might explain why Bcl-2-transfected cells retained their sensitivity to taxanes in the present experiment.
Phosphorylation (phosphorylation) of Bcl-2 associated with apoptosis
1) Confidence 0.81 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.44 Pain Relevance 0
Therefore, it is unlikely that alterations of Bcl-2 family of proteins or phosphorylation of Bad are responsible for apoptosis seen in HepG2 and Hep3B cells following U0126 treatment.
Phosphorylation (phosphorylation) of Bcl-2 associated with apoptosis
2) Confidence 0.14 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.85 Pain Relevance 0
As expected levels of phosphorylated AKT, Bcl-2, Bcl-xL and survivin were significantly reduced in tumors from mice treated with the reg4 antibody compared to control.
Phosphorylation (phosphorylated) of Bcl-2 associated with cancer
3) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760775 Disease Relevance 1.00 Pain Relevance 0
Because systemic treatment with the antibody reduces tumor growth and increases sensitivity to gemcitabine treatment, we used western blot analysis to monitor in tumors the influence of reg4 antibody treatment on the intracellular levels of proteins associated with apoptosis (phosphorylated AKT, Bcl-2, Bcl-xL and survivin) and cell cycle (cyclin D1).
Phosphorylation (phosphorylated) of Bcl-2 associated with cancer and apoptosis
4) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760775 Disease Relevance 1.05 Pain Relevance 0
Starvation induces Jun N-terminal kinase 1 (Jnk1) activity, which phosphorylates Bcl-2, thereby disrupting the interaction between Beclin 1 and Bcl-2 to induce autophagy [21].
Phosphorylation (phosphorylates) of Bcl-2 associated with starvation
5) Confidence 0.10 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.75 Pain Relevance 0
However, we did not observe any effect of PSA on the levels of Bcl-2 phosphorylation (Supplementary Material, Fig.
Phosphorylation (phosphorylation) of Bcl-2
6) Confidence 0.08 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0 Pain Relevance 0
Autophagy is regulated by other mechanisms such as the phosphorylation of Bcl-2, which modulates autophagy via its interaction with Beclin-1 (43).
Phosphorylation (phosphorylation) of Bcl-2
7) Confidence 0.08 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0 Pain Relevance 0
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Phosphorylation (phosphorylated) of BclII
8) Confidence 0.02 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
This is brought about by Akt-mediated phosphorylation of the pro-apoptotic Bcl-2 family member Bad [273,274] and, via GSK3 phosphorylation and stabilisation of the anti-apoptotic Bcl-2 family member Mcl-1 [275].


Phosphorylation (phosphorylation) of Bcl-2 family member associated with apoptosis
9) Confidence 0.01 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.84 Pain Relevance 0

General Comments

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