INT123522

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Context Info
Confidence 0.80
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.36
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
plasma 1
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 53 83.84 Quite High
cINOD 5 50.00 Quite Low
Inflammation 6 40.60 Quite Low
COX2 1 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 36 98.52 Very High Very High Very High
Hepatotoxicity 39 92.00 High High
Toxicity 29 84.48 Quite High
Death 3 78.08 Quite High
Stress 3 74.08 Quite High
INFLAMMATION 9 50.00 Quite Low
Adenocarcinoma 1 50.00 Quite Low
Targeted Disruption 1 50.00 Quite Low
Prostatic Intraepithelial Neoplasia 1 50.00 Quite Low
Leukemia 1 45.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Phosphorylation (phosphorylated) of caspase-3
1) Confidence 0.80 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
In addition to plasma transaminases and histopathology, levels of cleaved caspase 3 and phosphorylated eIF2?
Phosphorylation (phosphorylated) of caspase 3 in plasma
2) Confidence 0.10 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.49 Pain Relevance 0.11
JNK phosphorylation, c-jun gene expression, and caspase-3
Phosphorylation (phosphorylation) of caspase-3
3) Confidence 0.04 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1082887 Disease Relevance 0.80 Pain Relevance 0.03

General Comments

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