INT123524

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) endosome (Cdkn1b) cell death (Cdkn1b)
nucleus (Cdkn1b) cell cycle (Cdkn1b) protein complex (Cdkn1b)
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 9 50.00 Quite Low
palliative 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 10 98.14 Very High Very High Very High
Cancer 327 87.12 High High
Apoptosis 100 83.72 Quite High
Targeted Disruption 3 71.92 Quite High
Toxicity 7 65.12 Quite High
Syndrome 2 58.32 Quite High
Glioma 104 50.00 Quite Low
INFLAMMATION 8 50.00 Quite Low
Adenocarcinoma 1 50.00 Quite Low
Prostatic Intraepithelial Neoplasia 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Maddika et al indicated that inhibitors of PI3-kinase or Akt not only inhibited CDK2 activation but also protected cells from Apoptin-induced cell death, and Akt-mediated activation of CDK2 was caused by direct phosphorylation as well as by the phosphorylation-induced degradation of its inhibitor p27 (Kip1) [32].
Phosphorylation (phosphorylation) of p27 associated with death
1) Confidence 0.29 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.00 Pain Relevance 0
Maddika et al indicated that inhibitors of PI3-kinase or Akt not only inhibited CDK2 activation but also protected cells from Apoptin-induced cell death, and Akt-mediated activation of CDK2 was caused by direct phosphorylation as well as by the phosphorylation-induced degradation of its inhibitor p27 (Kip1) [32].
Phosphorylation (phosphorylation) of Kip1 associated with death
2) Confidence 0.29 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.01 Pain Relevance 0
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Phosphorylation (phosphorylated) of p27
3) Confidence 0.27 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
The p27Kip1 protein is generally phosphorylated at Ser10 and Thr187 positions and its activity depends on its phosphorylation status.
Phosphorylation (phosphorylated) of p27Kip1
4) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.08 Pain Relevance 0
Therefore, we checked the phosphorylation status of p27Kip1 by immunoblot analysis and found that the treatments reduced the phosphorylation of p27Kip1 at Ser10 and Thr187 in both the cells lines compared to the controls.
Phosphorylation (phosphorylation) of p27Kip1
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.07 Pain Relevance 0
We also checked for the expression of PI3K and AKT molecules, which dictate the phosphorylation status of p27Kip1 and affect the activity of FOXO proteins.
Phosphorylation (phosphorylation) of p27Kip1
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
Therefore, we checked the phosphorylation status of p27Kip1 by immunoblot analysis and found that the treatments reduced the phosphorylation of p27Kip1 at Ser10 and Thr187 in both the cells lines compared to the controls.
Phosphorylation (phosphorylation) of p27Kip1
7) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.07 Pain Relevance 0

General Comments

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