INT123525

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.18
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
poly 1
Bax (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 9 60.40 Quite High
chemokine 21 50.00 Quite Low
cINOD 5 50.00 Quite Low
antagonist 3 35.44 Quite Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 120 98.34 Very High Very High Very High
Colon Cancer 26 87.24 High High
Metastasis 25 82.36 Quite High
Repression 7 66.56 Quite High
Toxicity 1 65.12 Quite High
Adhesions 39 61.84 Quite High
Suicidal Behaviour 27 55.04 Quite High
INFLAMMATION 2 50.00 Quite Low
Targeted Disruption 2 50.00 Quite Low
Adenocarcinoma 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Phosphorylation (phosphorylated) of BAX
1) Confidence 0.41 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
We had previously observed that estrogen prevented apoptosis in T-antigen-synchronized cultures, following p53 activation (as indicated by p53 phosphorylation at serine 392, and activation of prototypic p53-responsive genes like MDM2, p21/Waf-1 and Bax) [37].
Phosphorylation (phosphorylation) of Bax associated with apoptosis
2) Confidence 0.20 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.42 Pain Relevance 0.03
Antibodies specific for Bax, Bak, Mcl-1, Bim, phospho-Bad, total Bad, Puma, Bcl-2, Bcl-XL, cleaved poly-ADP ribose polymerase (PARP), cleaved caspase-3, cleaved caspase-9, cleaved caspase-8, and cleaved caspase-7 were from (Cell Signaling, Danvers, MA, USA).
Phosphorylation (phospho) of Bax in poly
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.70 Pain Relevance 0

General Comments

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