INT123527

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ar) nucleus (Ar) enzyme binding (Ar)
DNA binding (Ar) transcription factor binding (Ar) cytoplasm (Ar)
Ar (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 99.96 Very High Very High Very High
withdrawal 4 79.28 Quite High
cINOD 5 50.00 Quite Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 32 50.00 Quite Low
Adenocarcinoma 2 50.00 Quite Low
INFLAMMATION 2 50.00 Quite Low
Targeted Disruption 2 50.00 Quite Low
Prostatic Intraepithelial Neoplasia 1 50.00 Quite Low
Toxicity 1 16.84 Low Low
Cancer 30 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 5 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was clearly evident from Western blot analysis of the total protein lysate derived from the dorsolateral prostate tissues with PIN lesions that expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, and BclII is down-regulated more effectively by celecoxib.
Negative_regulation (down-regulated) of Gene_expression (expression) of androgen receptor
1) Confidence 0.10 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0 Pain Relevance 0
The DHT-triggered stimulation of SphK1 activity was also completely inhibited in presence of androgen receptor antagonist (Fig. 5B).


Negative_regulation (inhibited) of Gene_expression (presence) of androgen receptor associated with antagonist
2) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0.14

General Comments

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