INT123528

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.08
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfa) cell proliferation (Vegfa) extracellular space (Vegfa)
growth (Vegfa) extracellular region (Vegfa) plasma membrane (Vegfa)
Anatomy Link Frequency
vasculature 2
granulation 2
Vegfa (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 42 99.64 Very High Very High Very High
Calcitonin gene-related peptide 17 99.54 Very High Very High Very High
antagonist 3 96.08 Very High Very High Very High
COX-2 inhibitor 7 90.24 High High
Inflammatory mediators 1 90.24 High High
Inflammation 50 84.56 Quite High
aspirin 4 79.36 Quite High
Neuropeptide 4 76.28 Quite High
qutenza 3 72.64 Quite High
endometriosis 4 68.52 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 23 99.90 Very High Very High Very High
Injury 54 99.40 Very High Very High Very High
Ovarian Cancer 84 98.80 Very High Very High Very High
Cancer 258 97.10 Very High Very High Very High
Stomach Cancer 3 93.60 High High
Metastasis 3 93.48 High High
Targeted Disruption 22 92.64 High High
Wound Healing 27 91.92 High High
Malignant Neoplastic Disease 88 90.56 High High
INFLAMMATION 64 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TZDs can reduce the production of proangiogenic FGF and VEGF
Negative_regulation (reduce) of Gene_expression (production) of VEGF
1) Confidence 0.57 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396401 Disease Relevance 0.76 Pain Relevance 0.05
VEGFA mRNA expression by RT-PCR and VEGFA protein expression by Western-blot
Negative_regulation (blot) of Gene_expression (expression) of VEGFA mRNA
2) Confidence 0.40 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.35 Pain Relevance 0
Expression of vascular endothelial growth factor was more markedly reduced in CGRP(-/-) than in WT.
Negative_regulation (reduced) of Gene_expression (Expression) of vascular endothelial growth factor
3) Confidence 0.39 Published 2008 Journal Gastroenterology Section Body Doc Link 18054007 Disease Relevance 0.17 Pain Relevance 0
In addition, celecoxib treatment caused an increase in apoptosis and decreased vascular endothelial growth factor expression in treated animals.
Negative_regulation (decreased) of Gene_expression (expression) of vascular endothelial growth factor associated with apoptosis
4) Confidence 0.35 Published 2010 Journal Cancer Prev Res (Phila) Section Abstract Doc Link 20103725 Disease Relevance 1.33 Pain Relevance 0.09
Expression of both vascular endothelial growth factor (VEGF) and FGF-1 was suppressed.
Negative_regulation (suppressed) of Gene_expression (Expression) of vascular endothelial growth factor
5) Confidence 0.34 Published 2005 Journal Biomed. Pharmacother. Section Abstract Doc Link 16507395 Disease Relevance 0.61 Pain Relevance 0.30
The suppressed healing in CGRP-/- was accompanied by reduction in expressions of vascular endothelial growth factor (VEGF) in the wound granulation tissues.
Negative_regulation (reduction) of Gene_expression (expressions) of vascular endothelial growth factor in granulation associated with injury and calcitonin gene-related peptide
6) Confidence 0.33 Published 2008 Journal Biomed. Pharmacother. Section Abstract Doc Link 18430544 Disease Relevance 0.86 Pain Relevance 0.69
It was clearly evident from Western blot analysis of the total protein lysate derived from the dorsolateral prostate tissues with PIN lesions that expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, and BclII is down-regulated more effectively by celecoxib.
Negative_regulation (down-regulated) of Gene_expression (expression) of vascular endothelial growth factor
7) Confidence 0.24 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0 Pain Relevance 0
Consistent with the marked reduction in mammary vasculature in Cox-2 null mammary tissues, the expression of several angiogenesis-associated genes was decreased (Figure 5b), including VEGF (which encodes vascular endothelial growth factor), Ang1 and Ang2 (which encode Tie-2 ligands), and Flk-1 and Flt-1 (which encode vascular endothelial growth factor receptors).
Negative_regulation (decreased) of Gene_expression (expression) of vascular endothelial growth factor in vasculature
8) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.56 Pain Relevance 0
Several in vivo [9] and in vitro [10-13] experiments have demonstrated reduced tumour growth [9], decreased proliferation [11], cell cycle arrest [10], attenuated metalloprotease-dependent motility and invasive activity [13], and reduced expression of vascular endothelial growth factor expression [14] by NSAIDs in models for EOC.
Negative_regulation (reduced) of Gene_expression (expression) of vascular endothelial growth factor associated with cancer, ovarian cancer and cinod
9) Confidence 0.09 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 1.19 Pain Relevance 0.60
Several in vivo [9] and in vitro [10-13] experiments have demonstrated reduced tumour growth [9], decreased proliferation [11], cell cycle arrest [10], attenuated metalloprotease-dependent motility and invasive activity [13], and reduced expression of vascular endothelial growth factor expression [14] by NSAIDs in models for EOC.
Negative_regulation (reduced) of Gene_expression (expression) of vascular endothelial growth factor associated with cancer, ovarian cancer and cinod
10) Confidence 0.09 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 1.25 Pain Relevance 0.60

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