INT123529

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Context Info
Confidence 0.80
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.69
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1A) nucleoplasm (CDKN1A) nucleus (CDKN1A)
cell cycle (CDKN1A) kinase activity (CDKN1A) cytoplasm (CDKN1A)
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 53 85.40 High High
Inflammation 61 69.04 Quite High
Inflammatory mediators 7 62.44 Quite High
cerebral cortex 18 60.40 Quite High
cytokine 31 57.40 Quite High
cINOD 22 50.00 Quite Low
antagonist 11 34.80 Quite Low
Central nervous system 15 27.68 Quite Low
chemokine 20 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 440 99.92 Very High Very High Very High
Disease 71 96.36 Very High Very High Very High
Cancer 165 95.84 Very High Very High Very High
Cyst 42 92.04 High High
Myeloproliferative Disorder 45 87.04 High High
Stress 10 84.76 Quite High
Lung Cancer 7 79.16 Quite High
Polycystic Kidney Disease 72 76.72 Quite High
Hypertrophy 2 74.28 Quite High
Diabetes Mellitus 2 73.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When p21 is phosphorylated by upstream molecules such as phosphorylated Akt, p21 is translocated into the cytosol to act as an anti-apoptotic protein.
Phosphorylation (phosphorylated) of p21 associated with apoptosis
1) Confidence 0.80 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 1.28 Pain Relevance 0
We had previously observed that estrogen prevented apoptosis in T-antigen-synchronized cultures, following p53 activation (as indicated by p53 phosphorylation at serine 392, and activation of prototypic p53-responsive genes like MDM2, p21/Waf-1 and Bax) [37].
Phosphorylation (phosphorylation) of Waf-1 associated with apoptosis
2) Confidence 0.79 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.42 Pain Relevance 0.03
We had previously observed that estrogen prevented apoptosis in T-antigen-synchronized cultures, following p53 activation (as indicated by p53 phosphorylation at serine 392, and activation of prototypic p53-responsive genes like MDM2, p21/Waf-1 and Bax) [37].
Phosphorylation (phosphorylation) of p21 associated with apoptosis
3) Confidence 0.79 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.42 Pain Relevance 0.03
When p21 is phosphorylated by upstream molecules such as phosphorylated Akt, p21 is translocated into the cytosol to act as an anti-apoptotic protein.
Phosphorylation (phosphorylated) of p21 associated with apoptosis
4) Confidence 0.35 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 1.27 Pain Relevance 0
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Phosphorylation (phosphorylated) of CIP1
5) Confidence 0.35 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
Deacetylation of p53 by HDAC1–3 or SIRT1 inhibits its transcriptional activity, and subsequently, the activation of its downstream molecules, Bax and p21 [93–95].
Phosphorylation (Deacetylation) of p21
6) Confidence 0.21 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.82 Pain Relevance 0
Concerning cell cycle, PKB is able to phosphorylate cdk inhibitors, such as p21 and p27, leading to PCNA activation [168, 169].
Phosphorylation (phosphorylate) of p21
7) Confidence 0.15 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.80 Pain Relevance 0.14
AKT1, which is activated through the phosphatidylinositol 3-kinase (PI3K) pathway, is known to stimulate cell cycle progression (via p21 phosphorylation and release from CDK2) and to play an important role in promoting cell survival through the suppression of apoptosis [72]-[74].
Phosphorylation (phosphorylation) of p21 associated with apoptosis
8) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.62 Pain Relevance 0.09

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