INT123551

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 11.60
Pain Relevance 6.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp2) extracellular space (Mmp2) extracellular region (Mmp2)
proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2) nucleus (Mmp2)
Anatomy Link Frequency
lymphocyte 1
band 1
heart 1
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 301 100.00 Very High Very High Very High
cINOD 9 100.00 Very High Very High Very High
dexamethasone 8 100.00 Very High Very High Very High
palliative 131 99.12 Very High Very High Very High
diclofenac 7 98.72 Very High Very High Very High
Inflammation 107 97.32 Very High Very High Very High
cytokine 69 96.96 Very High Very High Very High
antagonist 25 95.52 Very High Very High Very High
Opioid 1 89.92 High High
Chronic pancreatitis 2 89.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 152 100.00 Very High Very High Very High
Apoptosis 45 100.00 Very High Very High Very High
Pre-term Labor 26 99.74 Very High Very High Very High
Pancreatic Cancer 7 99.70 Very High Very High Very High
Fistula 2 99.60 Very High Very High Very High
Metastasis 188 99.48 Very High Very High Very High
Cancer 523 99.46 Very High Very High Very High
Stroke 81 99.36 Very High Very High Very High
Hepatocellular Cancer 174 99.04 Very High Very High Very High
Lifespan 25 98.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gelatin zymography assays clearly showed that tumor MMP2 activity was stronger in the palliative resection group (Figure 2A1); the normalized optical density of the band presenting MMP2 activity was significantly elevated (1.4-fold, P < 0.01, Figure 2A2), in accord with up-regulation of the MMP2 protein level in the palliative resection group, that is, 73.7 ± 8.0 ng/mg versus 57.9 ± 10.1 ng/mg (P < 0.01, Figure 2A3).
Regulation (regulation) of MMP2 in band associated with cancer and palliative
1) Confidence 0.57 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.52 Pain Relevance 0.54
We report that MMP-2 is under the control of nitric oxide (NO)/nitric oxide synthase (NOS) system.
Regulation (under) of MMP-2 associated with metalloproteinase
2) Confidence 0.55 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16386243 Disease Relevance 0.70 Pain Relevance 0.70
Marimastat treatment during chronic CCl4 administration, however, did not affect hepatic transcript levels of MMP-2 (Figure 6A), or MMP-3 (Figure 6B), compared to vehicle treated animals.
Neg (not) Regulation (affect) of MMP-2
3) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.30 Pain Relevance 0.06
inhibited HCC and extended the lifespan of mice and could be attributed to anti-angiogenesis [14,16]; SYY directly down-regulated MMP2 and VEGF and inhibited HCC growth and metastasis [15].
Regulation (regulated) of MMP2 associated with lifespan, hepatocellular cancer and metastasis
4) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.24 Pain Relevance 0.28
In addition, genes involved in the regulation of MMP2 (gelatinase A), such as MMP15 were found down-regulated by BCG treatment.
Regulation (regulation) of MMP2
5) Confidence 0.38 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.32 Pain Relevance 0.03
Based on our in vitro and in vivo studies, we considered that inhibition of the metastasis-enhancing effects due to dysregulation of MMP2/TIMP2 and VEGF might further improve operative efficacy in patients with HCC.
Regulation (dysregulation) of MMP2 associated with hepatocellular cancer and metastasis
6) Confidence 0.25 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.16 Pain Relevance 0.22
Indeed, with increasing complexity of the model system, the importance of MMP-2 and MMP-9 became apparent.
Regulation (importance) of MMP-2 associated with metalloproteinase
7) Confidence 0.20 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450297 Disease Relevance 0.90 Pain Relevance 0.56
There is no effect on MMP-2, neither after stroke nor after hypothermic treatment up to 24 hours after the insult [104].
Neg (no) Regulation (effect) of MMP-2 associated with stroke
8) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 1.07 Pain Relevance 0.07
In addition, TM treatment inhibited tumor cell invasiveness by down-regulating MMP2 levels.
Regulation (regulating) of MMP2 associated with cancer
9) Confidence 0.18 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.25 Pain Relevance 0.07
Since we did not detect any significant changes in the levels of MMP-2 or MMP-9 activity between 66cl4beta3 and 66cl4pBabe cells by gelatin zymography, cooperation between ?
Neg (not) Regulation (changes) of MMP-2 associated with metalloproteinase
10) Confidence 0.08 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1557720 Disease Relevance 0.21 Pain Relevance 0.68
Serratia mercenses ATCC 13880 was used as a positive control for gelatinase production test.


Regulation (control) of gelatinase
11) Confidence 0.06 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2424041 Disease Relevance 0.09 Pain Relevance 0.03
This study was undertaken to determine the effect of dexamethasone on apoptosis and matrix metalloproteinase 2 (MMP-2) activity compared with two nonsteroidal anti-inflammatory drugs (NSAIDs), piroxicam and diclofenac.
Spec (determine) Regulation (effect) of matrix metalloproteinase 2 associated with inflammation, cinod, metalloproteinase, apoptosis, diclofenac and dexamethasone
12) Confidence 0.05 Published 2005 Journal Med. Sci. Monit. Section Abstract Doc Link 15990687 Disease Relevance 0.47 Pain Relevance 0.52
While MMP-9 has been found to play a role in the events associated with term and preterm labor, comparable changes in MMP-2 protein levels and activity are often not reported.
Regulation (changes) of MMP-2 associated with pre-term labor
13) Confidence 0.04 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.46 Pain Relevance 0.24
More recently, they have shown that rats that underwent the surgical introduction of an aortocaval fistula had much less of a change in MMP-2 levels and in collagen volume fraction of the heart if they were treated with Bosentan, an endothelin receptor antagonist [77].
Regulation (change) of MMP-2 in heart associated with fistula and antagonist
14) Confidence 0.04 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.64 Pain Relevance 0.32
TGF-beta1 decreased MMP-1 mRNA expression, while only slightly affecting the MMP-2 and MMP-3 mRNA and/or protein.
Regulation (affecting) of MMP-2
15) Confidence 0.03 Published 2006 Journal J Endod Section Abstract Doc Link 16934628 Disease Relevance 0.23 Pain Relevance 0.45
We examined the effect of a nonsteroidal anti-inflammatory drug (NSAID), piroxicam, on apoptosis and matrix metalloproteinase 2 (MMP-2) activity compared with diclofenac and dexamethasone.
Spec (examined) Regulation (effect) of metalloproteinase 2 associated with inflammation, metalloproteinase, cinod, apoptosis, dexamethasone and diclofenac
16) Confidence 0.02 Published 2004 Journal Int J Tissue React Section Abstract Doc Link 15573686 Disease Relevance 0.58 Pain Relevance 0.47
However, CXCL14 clearly increased invasiveness of pancreatic cancer cells without affecting MMP-2 and VEGF secretion, whereas CXCL14 influenced NFkB p65 levels.
Neg (without) Regulation (affecting) of MMP-2 associated with pancreatic cancer
17) Confidence 0.02 Published 2008 Journal Cancer Lett. Section Abstract Doc Link 18054154 Disease Relevance 0.69 Pain Relevance 0.25
Effect of piroxicam on matrix metalloproteinase 2 and apoptosis.
Regulation (Effect) of metalloproteinase 2 associated with metalloproteinase and apoptosis
18) Confidence 0.01 Published 2004 Journal Int J Tissue React Section Title Doc Link 15573686 Disease Relevance 0.63 Pain Relevance 0.54
Blood and CSF levels of HIV viral load, monocyte chemotactic protein-1, macrophage colony-stimulating factor (M-CSF), matrix metalloproteinase-2, and tumor necrosis factor-alpha were measured in addition to CD4 lymphocyte cell count.
Regulation (measured) of matrix metalloproteinase-2 in lymphocyte
19) Confidence 0.00 Published 2005 Journal Neurology Section Body Doc Link 15753420 Disease Relevance 0.16 Pain Relevance 0

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