INT123558

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.45
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Atf3) nucleus (Atf3) DNA binding (Atf3)
Anatomy Link Frequency
primary sensory neurons 2
Atf3 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 22 98.90 Very High Very High Very High
diabetic neuropathy 3 98.60 Very High Very High Very High
unmyelinated 2 76.52 Quite High
hypoalgesia 1 40.16 Quite Low
Action potential 6 37.32 Quite Low
Peripheral nerve injury 1 33.40 Quite Low
imagery 5 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
nav1.3 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 9 99.98 Very High Very High Very High
Fibrosis 19 98.90 Very High Very High Very High
Diabetic Neuropathy 3 98.60 Very High Very High Very High
Arrhythmias 2 Under Development 27 94.92 High High
Nervous System Injury 4 89.84 High High
Heart Arrhythmia 16 58.80 Quite High
Aging 10 51.32 Quite High
Disease 4 50.00 Quite Low
Disease Progression 1 47.84 Quite Low
Hypoalagesia 1 40.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diabetes-induced expression of activating transcription factor 3 in mouse primary sensory neurons.
Positive_regulation (induced) of Gene_expression (expression) of activating transcription factor 3 in primary sensory neurons associated with diabetes mellitus
1) Confidence 0.70 Published 2004 Journal J. Peripher. Nerv. Syst. Section Title Doc Link 15574137 Disease Relevance 0.82 Pain Relevance 0.21
Moreover, that occurrence of large areas of fibrosis in mice with a severe phenotype was preceded by large overexpression of Egr1 and Atf3 in these mice and not in mice with a mild phenotype, which have much less fibrosis, confirms our hypothesis that these transcription factors are involved in myocardial rearrangements [10].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Atf3 associated with fibrosis
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.64 Pain Relevance 0.22

General Comments

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