INT123563

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Context Info
Confidence 0.55
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 19
Disease Relevance 16.56
Pain Relevance 5.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Rock1) cytoskeleton (Rock1) cytoskeleton organization (Rock1)
cytoplasm (Rock1)
Anatomy Link Frequency
eye 2
neuronal 2
dorsal 1
leukocyte 1
capillary 1
Rock1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 100.00 Very High Very High Very High
Abeta 10 99.92 Very High Very High Very High
tramadol 4 99.76 Very High Very High Very High
intrathecal 3 99.74 Very High Very High Very High
ischemia 36 99.52 Very High Very High Very High
Arthritis 20 99.20 Very High Very High Very High
Pain 18 98.64 Very High Very High Very High
cINOD 1 98.52 Very High Very High Very High
Antinociceptive 8 97.64 Very High Very High Very High
diclofenac 4 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Eye Disease 12 99.96 Very High Very High Very High
Diabetes Mellitus 204 99.56 Very High Very High Very High
Proliferative Vitreoretinopathy 84 99.52 Very High Very High Very High
Cv Unclassified Under Development 12 99.52 Very High Very High Very High
Adhesions 132 99.32 Very High Very High Very High
Arthritis 20 99.20 Very High Very High Very High
Diabetic Macular Edema 312 98.88 Very High Very High Very High
Pain 18 98.64 Very High Very High Very High
Death 12 97.96 Very High Very High Very High
Disease 27 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fasudil, a ROCK inhibitor, and tramadol were also effective in both models; however, diclofenac was effective only in the AIA model.
Negative_regulation (inhibitor) of ROCK associated with tramadol, diclofenac and arthritis
1) Confidence 0.55 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20534789 Disease Relevance 1.30 Pain Relevance 1.22
Whereas further basic and clinical studies to reveal the effectiveness and safety of ROCK inhibitor are needed for clinical use in the field of eye diseases, ROCK inhibition might become a novel therapeutic strategy in the total management of DR from its early to late stages.



Negative_regulation (inhibition) of ROCK in eye associated with diabetic macular edema and eye disease
2) Confidence 0.44 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 0.79 Pain Relevance 0
Fasudil, a potent and selective ROCK inhibitor, is relatively safe and effective in the treatment of cardiovascular disease including cerebral and coronary vasospasm, angina, hypertension, and heart failure with no serious adverse side effect in fasudil-treated patients [36].
Negative_regulation (inhibitor) of ROCK in heart associated with cardiovascular disease, hypertension, cva, coronary vasospasm and myocardial infarction
3) Confidence 0.44 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 1.23 Pain Relevance 0.08
In this study, we infused either control (PBS) or a ROCK inhibitor, Y27632 (2 mM or 20 mM, 12 microl/day for 14 days) into the intrathecal space of adult rats starting immediately after a cervical 4/5 dorsal column transection.
Negative_regulation (inhibitor) of ROCK in dorsal associated with dorsal column and intrathecal
4) Confidence 0.41 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 16154567 Disease Relevance 0.34 Pain Relevance 0.23
In this study, antinociceptive effects of AS1892802 [1-[(1S)-2-hydroxy-1-phenylethyl]-3-[4-(pyridin-4-yl)phenyl]urea], a novel and highly selective ROCK inhibitor, were investigated in two rat models of arthritis.
Negative_regulation (inhibitor) of ROCK associated with antinociceptive and arthritis
5) Confidence 0.41 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20534789 Disease Relevance 1.25 Pain Relevance 0.93
Whereas further basic and clinical studies to reveal the effectiveness and safety of ROCK inhibitor are needed for clinical use in the field of eye diseases, ROCK inhibition might become a novel therapeutic strategy in the total management of DR from its early to late stages.



Negative_regulation (inhibitor) of ROCK in eye associated with diabetic macular edema and eye disease
6) Confidence 0.33 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 0.81 Pain Relevance 0.03
Moreover, the therapeutic potential of ROCK inhibitor in the total management of diabetic retinopathy is discussed.


1.

Negative_regulation (inhibitor) of ROCK associated with diabetic macular edema
7) Confidence 0.33 Published 2010 Journal Journal of Ophthalmology Section Abstract Doc Link PMC2905943 Disease Relevance 0.53 Pain Relevance 0
These studies suggest that ROCK inhibitor would protect against neuronal damage by acting directly on neurons.
Negative_regulation (inhibitor) of ROCK in neuronal
8) Confidence 0.33 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 1.05 Pain Relevance 0.14
Our results indicate that ROCK inhibition suppresses PVR progression in later DR stages.

3.4.

Negative_regulation (inhibition) of ROCK associated with diabetic macular edema and proliferative vitreoretinopathy
9) Confidence 0.33 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 1.02 Pain Relevance 0.03
We then describe our current knowledge about ROCK inhibition as a new strategy in the total management of DR from its early to late stages.

2.

Negative_regulation (inhibition) of ROCK associated with diabetic macular edema
10) Confidence 0.33 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 0.79 Pain Relevance 0
We thus need further examination regarding the safety and adverse effects of ROCK inhibitor before its clinical use in the field of intraocular diseases.
Negative_regulation (inhibitor) of ROCK associated with disease
11) Confidence 0.33 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 1.30 Pain Relevance 0.09
Moreover, ROCK inhibition attenuates ischemia-induced retinal neuronal cell death by inhibiting leukocytes extravasation and release of proinflammatory cytokines such as TNF-?
Negative_regulation (inhibition) of ROCK in neuronal associated with ischemia, death and cytokine
12) Confidence 0.33 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 1.18 Pain Relevance 0.15
These data suggest that inhibition of Rho/ROCK pathway leads to neuroprotective effect and promote retinal cell survival during diabetes.


4.

Negative_regulation (inhibition) of Rho/ROCK associated with diabetes mellitus
13) Confidence 0.33 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 1.07 Pain Relevance 0.12
We demonstrated that ROCK inhibitor could inhibit VEGF-elicited bovine retinal capillary endothelial cell (BREC) migration and proliferation in vitro and corneal neovascularization in vivo.
Negative_regulation (inhibitor) of ROCK in capillary associated with corneal neovascularization
14) Confidence 0.32 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 0.65 Pain Relevance 0
Treatment with intravitreal injection of fasudil significantly decreased retinal leukocyte adhesion in diabetic rat mediated through reduction of ROCK activation.
Negative_regulation (reduction) of ROCK in leukocyte associated with diabetes mellitus and adhesions
15) Confidence 0.32 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 1.17 Pain Relevance 0.07
Inhibition of the Rho-ROCK pathway may underlie the ability of nonsteroidal anti-inflammatory drugs and statins to reduce Abeta production.
Negative_regulation (Inhibition) of Rho-ROCK associated with inflammation, cinod and abeta
16) Confidence 0.32 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20395307 Disease Relevance 0.85 Pain Relevance 0.55
One week after septuple rhizotomy, administration of intrathecal Y-27632, an antagonist of Rho-kinase (ROCK), increased the density of both fiber types over vehicle-treated controls.
Negative_regulation (antagonist) of ROCK associated with antagonist and intrathecal
17) Confidence 0.25 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15574730 Disease Relevance 0.59 Pain Relevance 0.98
To examine behavioral effects of both cervical rhizotomy and ROCK inhibition, we examined responses to evoked pain: mechanical and thermal allodynia and cold hyperalgesia in the forepaw were examined after single, double, and quadruple rhizotomies of dorsal roots of the brachial plexus.
Spec (examine) Negative_regulation (inhibition) of ROCK in brachial plexus associated with pain, hyperalgesia, cold hyperalgesia and allodynia
18) Confidence 0.25 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15574730 Disease Relevance 0.65 Pain Relevance 1.12
Abl inhibition of NMDA currents is blocked by the ROCK inhibitor Y-27632
Negative_regulation (inhibitor) of ROCK
19) Confidence 0.09 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.05

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