INT123577

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.78
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Baat) peroxisome (Baat) transferase activity, transferring acyl groups (Baat)
molecular_function (Baat) lipid metabolic process (Baat)
Anatomy Link Frequency
spinal 2
neurons 2
Baat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 5 100.00 Very High Very High Very High
Raphe 6 99.44 Very High Very High Very High
Rostral ventrolateral medulla 3 93.68 High High
narcan 1 91.64 High High
antagonist 1 91.28 High High
Opioid 1 90.84 High High
opiate 1 86.64 High High
agonist 1 85.36 High High
Enkephalin 1 82.40 Quite High
Raphe magnus 1 78.72 Quite High
Disease Link Frequency Relevance Heat
Obesity 26 100.00 Very High Very High Very High
Fever 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Noxious stimulation suppressed BAT activation, suggesting that cells inhibited by noxious stimulation facilitate spinal circuits controlling BAT.
Negative_regulation (suppressed) of Positive_regulation (activation) of BAT in spinal associated with obesity
1) Confidence 0.58 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16436606 Disease Relevance 1.04 Pain Relevance 0.45
Microinjection of glycine (0.5 M, 60 nl) to inhibit local neurons in the rostral raphe pallidus (RPa) selectively reversed the intracerebroventricular fentanyl-evoked increases in BAT SNA and HR, while the fentanyl-evoked excitation in RSNA, the pressor responses, and the tachycardic responses were reversed by inhibition of neurons in the rostral ventrolateral medulla (RVLM).
Negative_regulation (reversed) of Positive_regulation (increases) of BAT in neurons associated with rostral ventrolateral medulla, obesity, intracerebroventricular and raphe
2) Confidence 0.33 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15576661 Disease Relevance 0.74 Pain Relevance 0.57

General Comments

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