INT12358

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1987
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 3.34
Pain Relevance 8.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
neurons 6
spinal 4
nucleus accumbens 3
ganglia 3
output neurons 2
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 25 100.00 Very High Very High Very High
Enkephalin 24 100.00 Very High Very High Very High
Pain 18 100.00 Very High Very High Very High
Spinal cord 9 100.00 Very High Very High Very High
Dynorphin 9 100.00 Very High Very High Very High
Serotonin 9 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
opiate 16 99.84 Very High Very High Very High
Root ganglion neuron 2 99.56 Very High Very High Very High
Dopamine 126 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 5 99.82 Very High Very High Very High
Ganglion Cysts 2 99.36 Very High Very High Very High
Neuropathic Pain 4 97.96 Very High Very High Very High
Colitis 2 97.00 Very High Very High Very High
Diverticulitis 1 96.64 Very High Very High Very High
INFLAMMATION 9 96.00 Very High Very High Very High
Abdominal Pain 1 95.36 Very High Very High Very High
Nervous System Injury 2 94.92 High High
Pain 8 94.88 High High
Nociception 22 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altered tachykinin expression by dorsal root ganglion neurons in a rat model of neuropathic pain.
Regulation (Altered) of Gene_expression (expression) of tachykinin in neurons associated with ganglion cysts, pain, neuropathic pain and root ganglion neuron
1) Confidence 0.60 Published 1994 Journal Pain Section Title Doc Link 7816489 Disease Relevance 0.45 Pain Relevance 0.58
The changes in PPT mRNA expression were prevented by concurrent local anesthesia of the sciatic nerve.
Regulation (changes) of Gene_expression (expression) of PPT mRNA in sciatic nerve associated with anesthesia and sciatic nerve
2) Confidence 0.50 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7970189 Disease Relevance 0.32 Pain Relevance 0.57
The data suggest that sigma receptor activity, directly or indirectly, affects proenkephalin and protachykinin mRNA expression in striatal neurons.
Regulation (affects) of Gene_expression (expression) of protachykinin mRNA in neurons
3) Confidence 0.37 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1968844 Disease Relevance 0 Pain Relevance 0
The selectivity suggests that 5-HT2A receptor upregulation following DA depletion is capable of regulating tachykinin biosynthesis without influencing enkephalin expression in striatal output neurons.
Regulation (regulating) of Gene_expression (biosynthesis) of tachykinin in output neurons associated with dopamine and enkephalin
4) Confidence 0.36 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11483243 Disease Relevance 0 Pain Relevance 0.59
The level of PPT mRNA in the striatum was also decreased in response to ADX, but there were no significant diurnal changes in the expression of the PPT mRNA either in the intact or in the ADX animals.
Neg (no) Regulation (changes) of Gene_expression (expression) of PPT mRNA in striatum
5) Confidence 0.27 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1645434 Disease Relevance 0.08 Pain Relevance 0.04
The effect of N-methyl-D-aspartate (NMDA) receptor blockade on the expression of preproenkephalin (PPE), preprotachykinin (PPT) and preprodynorphin (PPD) mRNAs in the caudate-putamen and nucleus accumbens was assessed with the non-competitive NMDA receptor antagonist MK-801.
Regulation (effect) of Gene_expression (expression) of PPT in nucleus accumbens associated with nucleus accumbens and nmda receptor antagonist
6) Confidence 0.27 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7769991 Disease Relevance 0 Pain Relevance 0.31
Injury-induced changes in PPT mRNA expression by affected DRG neurons included: (1) at early postoperative times, generally increased levels of PPT mRNA associated with small and intermediate-size B cells exhibiting normal morphology, (2) at late postoperative times, markedly decreased levels of PPT mRNA associated with degenerating B cells, and (3) induction of PPT gene expression by large A cells which is highly correlated with degenerative morphological changes.
Regulation (changes) of Gene_expression (expression) of PPT mRNA in neurons associated with injury
7) Confidence 0.26 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.47 Pain Relevance 0.30
The injection of METH did not significantly influence Tac1 expression on the lesioned side (?
Neg (not) Regulation (influence) of Gene_expression (expression) of Tac1
8) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.18
Although these results support previous studies suggesting an overall positive regulatory role of serotonin on striatal tachykinin biosynthesis, PPT and PPE gene regulation in certain striatal subregions may by differentially sensitive to lowered 5-HT neurotransmission.
Regulation (role) of Gene_expression (biosynthesis) of tachykinin associated with serotonin
9) Confidence 0.22 Published 1996 Journal Brain Res. Section Abstract Doc Link 8891265 Disease Relevance 0 Pain Relevance 0.20
The results of this study indicate that pretreatment with opiate ligands modulates the expression of tachykinin peptide and neurokinin receptor encoding mRNAs in spinal systems following a peripheral chemogenic inflammatory stimulus.
Regulation (modulates) of Gene_expression (expression) of tachykinin in spinal associated with opiate and inflammatory stimuli
10) Confidence 0.21 Published 1995 Journal Neuroscience Section Abstract Doc Link 7536308 Disease Relevance 0.33 Pain Relevance 0.71
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
Regulation (modulated) of in spinal cord Gene_expression (expression) of tachykinin in ganglia associated with pain, opiate and spinal cord
11) Confidence 0.21 Published 1995 Journal Neuroscience Section Title Doc Link 7536308 Disease Relevance 0.40 Pain Relevance 0.95
Thus, endogenous opioid systems may be involved in activity-induced changes in the expression of spinal tachykinin peptides and neurokinin receptors.
Regulation (changes) of Gene_expression (expression) of tachykinin in spinal associated with endogenous opioid
12) Confidence 0.19 Published 1995 Journal Neuroscience Section Abstract Doc Link 7536308 Disease Relevance 0.20 Pain Relevance 0.64
Dopaminergic regulation of striatonigral tachykinin and dynorphin gene expression: a study with the dopamine uptake inhibitor GBR-12909.
Regulation (regulation) of Gene_expression (expression) of tachykinin associated with dopamine, dynorphin and enkephalin
13) Confidence 0.18 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.66
Neonatal and adult 6-hydroxydopamine-induced lesions differentially alter tachykinin and enkephalin gene expression.
Regulation (alter) of Gene_expression (expression) of tachykinin associated with enkephalin
14) Confidence 0.13 Published 1987 Journal J. Neurochem. Section Title Doc Link 2889804 Disease Relevance 0 Pain Relevance 0.80
The present investigation examined the effects of neonatal and adult 6-hydroxydopamine (6-OHDA)-induced lesions of dopaminergic neurons on opioid and tachykinin peptides and their gene expression in the rat basal ganglia.
Spec (examined) Regulation (effects) of in dopaminergic neurons Gene_expression (expression) of tachykinin in basal ganglia associated with opioid
15) Confidence 0.11 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 2889804 Disease Relevance 0 Pain Relevance 0.55
The effect of N-methyl-D-aspartate (NMDA) receptor blockade on the expression of preproenkephalin (PPE), preprotachykinin (PPT) and preprodynorphin (PPD) mRNAs in the caudate-putamen and nucleus accumbens was assessed with the non-competitive NMDA receptor antagonist MK-801.
Regulation (effect) of in caudate-putamen Gene_expression (expression) of PPT in nucleus accumbens associated with nucleus accumbens and nmda receptor antagonist
16) Confidence 0.09 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7769991 Disease Relevance 0 Pain Relevance 0.31
Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves in trinitrobenzene sulphonic acid colitis.
Regulation (Prolonged) of Gene_expression (expression) of tachykinin in enteric nerves associated with colitis and neuropeptide
17) Confidence 0.08 Published 2008 Journal Neurogastroenterol. Motil. Section Title Doc Link 18208479 Disease Relevance 0.69 Pain Relevance 0.49
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
Regulation (modulated) of Gene_expression (expression) of tachykinin in ganglia associated with pain, opiate and spinal cord
18) Confidence 0.07 Published 1995 Journal Neuroscience Section Title Doc Link 7536308 Disease Relevance 0.40 Pain Relevance 0.95

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox