INT123584

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 10
Speculated 12
Reported most in Abstract
Documents 176
Total Number 195
Disease Relevance 83.00
Pain Relevance 78.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpa1) transmembrane transport (Trpa1)
Anatomy Link Frequency
neurons 36
sensory neurons 15
nociceptors 8
IB4 6
nerve 5
Trpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 969 100.00 Very High Very High Very High
antagonist 798 100.00 Very High Very High Very High
Mechanotransduction 219 100.00 Very High Very High Very High
nociceptor 1696 99.98 Very High Very High Very High
Pain 2592 99.96 Very High Very High Very High
agonist 1009 99.96 Very High Very High Very High
primary afferent fibers 17 99.84 Very High Very High Very High
c fibre 664 99.72 Very High Very High Very High
Inflammation 944 99.64 Very High Very High Very High
imagery 405 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 2550 99.96 Very High Very High Very High
Nociception 1245 99.92 Very High Very High Very High
Neuroblastoma 18 99.84 Very High Very High Very High
Hypersensitivity 944 99.64 Very High Very High Very High
INFLAMMATION 942 99.64 Very High Very High Very High
Injury 1957 99.52 Very High Very High Very High
Neuropathic Pain 2255 99.48 Very High Very High Very High
Nervous System Injury 787 99.44 Very High Very High Very High
Ganglion Cysts 2421 99.36 Very High Very High Very High
Dyspepsia 2 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPA1, a member of the transient receptor potential (TRP) family of ion channels, is expressed by dorsal root ganglion neurons and by cells of the inner ear, where it has proposed roles in sensing sound, painful cold, and irritating chemicals.
Gene_expression (expressed) of TRPA1 in inner ear associated with ganglion cysts, pain and root ganglion neuron
1) Confidence 0.78 Published 2006 Journal Neuron Section Abstract Doc Link 16630838 Disease Relevance 0.25 Pain Relevance 0.17
TRPA1 is a member of the Transient Receptor Potential (TRP) family of ion channels and is expressed in nociceptive neurons.
Gene_expression (expressed) of TRPA1 in neurons associated with nociception
2) Confidence 0.78 Published 2007 Journal Nature Section Abstract Doc Link 17237762 Disease Relevance 0.30 Pain Relevance 0.10
In a subclass of mouse nociceptors expressing TRPA1 channels, assessed by responses to the TRPA1 agonist mustard oil, nifedipine also produced large elevations in [Ca2+](i).
Gene_expression (expressing) of TRPA1 in nociceptors associated with nociceptor and agonist
3) Confidence 0.78 Published 2008 Journal Channels (Austin) Section Abstract Doc Link 18971630 Disease Relevance 0.16 Pain Relevance 0.45
Interestingly, both TRPA1 protein expression and mRNA were over-expressed in spinal cord and dorsal root ganglia (DRG) of mice treated with CFA, an effect that was fully prevented by the pre-treatment with the TRPA1 antagonist HC-030031.
Gene_expression (expression) of TRPA1 in dorsal root ganglia associated with antagonist and spinal cord
4) Confidence 0.78 Published 2010 Journal Pain Section Abstract Doc Link 20056530 Disease Relevance 0.76 Pain Relevance 1.06
TRPA1, a TRP ion channel expressed in chemosensory C-fibers, is activated by almost all oxidizing and electrophilic chemicals, including chlorine, acrolein, tear gas agents, and methyl isocyanate, the highly noxious chemical released in the Bhopal disaster.
Gene_expression (expressed) of TRPA1 in tear associated with c fibre
5) Confidence 0.78 Published 2010 Journal Proc Am Thorac Soc Section Abstract Doc Link 20601631 Disease Relevance 0.58 Pain Relevance 0.42
Small neurons (diameter <27 microm) were studied because TRPA1 is functionally present in these neurons which largely give rise to C-fiber afferents in vivo.
Gene_expression (present) of TRPA1 in neurons associated with c fibre
6) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link 20808441 Disease Relevance 0.09 Pain Relevance 0.19
Transfection of TRPA1 in HEK293 cells did not significantly alter the proportion or magnitude of mechanically-activated currents in HEK293 cells, indicating that TRPA1 alone is not sufficient to confer mechanical sensitivity.These parallel genetic and pharmacological data demonstrate that TRPA1 mediates the Slowly Adapting mechanically-activated currents in small-diameter IB4 negative neurons from adult mice.
Gene_expression (Transfection) of TRPA1 in IB4
7) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link 20808441 Disease Relevance 0.05 Pain Relevance 0.19
fiber neurons since TRPA1 is highly expressed by a subset of small- and medium-diameter neurons, the majority of which have unmyelinated axons in vivo.
Gene_expression (expressed) of TRPA1 in neurons associated with unmyelinated
8) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.18 Pain Relevance 0.93
Indeed, a recent study from our laboratory shows that TRPA1 channels are widely expressed by keratinocytes that lie in close apposition to the free nerve terminals of both A?
Gene_expression (expressed) of TRPA1 in keratinocytes
9) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.16 Pain Relevance 0.50
Here we show that transient receptor potential ankyrin 1 (TRPA1), expressed by sensory neurons in the pain pathway, is a receptor for H(2)O(2).
Gene_expression (expressed) of TRPA1 in sensory neurons associated with pain
10) Confidence 0.78 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18364033 Disease Relevance 0.29 Pain Relevance 0.34
Consequently to TRPA1 antisense oligodeoxynucleotide treatment there was a marked decrease of the expression of TRPA1 receptor in both sciatic nervous and spinal cord segments.
Gene_expression (expression) of TRPA1 in spinal cord segments associated with spinal cord
11) Confidence 0.78 Published 2008 Journal Neuroscience Section Abstract Doc Link 18272293 Disease Relevance 0.48 Pain Relevance 0.90
Transient receptor potential A1 (TRPA1) is selectively expressed in a subpopulation of pulmonary C-fiber afferents and has been considered as a major irritant sensor in the lung and airways.
Gene_expression (expressed) of TRPA1 in lung associated with c fibre
12) Confidence 0.78 Published 2010 Journal J. Appl. Physiol. Section Abstract Doc Link 20133428 Disease Relevance 0.15 Pain Relevance 0.25
Immunoreactive TRPV4 and TRPA1 were detected in pancreatic nerve fibers and in dorsal root ganglia neurons innervating the pancreas, which were identified by retrograde tracing.
Gene_expression (detected) of TRPA1 in neurons
13) Confidence 0.77 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20539005 Disease Relevance 0.94 Pain Relevance 0.94
TRPA1 is a member of the transient receptor potential (TRP) channel family expressed in sensory neurons.
Gene_expression (expressed) of TRPA1 in sensory neurons
14) Confidence 0.77 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17825279 Disease Relevance 0 Pain Relevance 0.07
RT-PCR analysis revealed the expression of TRPA1 and TRPV1, but not TRPM8, throughout the mouse intestine.
Gene_expression (expression) of TRPA1 in intestine
15) Confidence 0.77 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17825279 Disease Relevance 0 Pain Relevance 0.57
TRPA1, TRPM8, and TRPV1 expressions were examined by reverse transcription-polymerase chain reaction (RT-PCR).
Gene_expression (expressions) of TRPA1
16) Confidence 0.77 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17825279 Disease Relevance 0 Pain Relevance 0.30
These results suggest that TRPA1, but not TRPM8, are functionally expressed in the enteric nervous system throughout the mouse intestine on neurons that may also co-express TRPV1, yet the contractile responses to TRPA1 activation differ depending on their location along the intestine.
Neg (not) Gene_expression (expressed) of TRPA1 in intestine
17) Confidence 0.77 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17825279 Disease Relevance 0 Pain Relevance 0.54
Similarly, a recent study showed that overexpression of TRPA1 in neuroblastoma cell lines also does not confer novel mechanical sensitivity or induce any changes in endogenous mechanically-evoked currents in these heterologous cells [27].
Gene_expression (overexpression) of TRPA1 associated with neuroblastoma
18) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922334 Disease Relevance 0.17 Pain Relevance 0.09
To inhibit TRPA1 channel function but leave TRPA1 protein expression in the membrane intact, we used a selective TRPA1 antagonist, HC-030031 [15], to assess mechanically-activated currents in wild type neurons.
Gene_expression (expression) of TRPA1 protein in neurons associated with antagonist
19) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922334 Disease Relevance 0 Pain Relevance 0.08
To determine whether expression of TRPA1 alone in heterologous cells is capable of inducing mechanically-activated currents in the plasma membrane, HEK293 cells were cotransfected with rat TRPA1 and eGFP, or transfected with eGFP alone and cells were recorded 12–24 hrs later.
Spec (whether) Gene_expression (expression) of TRPA1 in plasma
20) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922334 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox