INT123588

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Context Info
Confidence 0.81
First Reported 2004
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.35
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Vgf) extracellular space (Vgf) extracellular region (Vgf)
Anatomy Link Frequency
nociceptors 2
melanocyte 1
nucleus 1
Vgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 28 99.76 Very High Very High Very High
nociceptor 3 99.04 Very High Very High Very High
Cannabinoid 1 96.76 Very High Very High Very High
antagonist 1 95.76 Very High Very High Very High
Neuronal excitability 6 94.24 High High
Dorsal horn 54 93.36 High High
Peripheral nerve injury 21 90.72 High High
Neuropathic pain 33 90.08 High High
allodynia 12 89.64 High High
Lasting pain 3 81.04 Quite High
Disease Link Frequency Relevance Heat
Erectile Dysfunction 14 97.68 Very High Very High Very High
Injury 33 92.12 High High
Nervous System Injury 93 90.72 High High
Neuropathic Pain 51 90.08 High High
Pain 6 81.04 Quite High
Hypersensitivity 15 41.76 Quite Low
Nociception 6 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The colocalization of VGF with peptidergic primary afferents, in agreement with previous reports in culture [10], suggests depolarisation and neurotrophin mediated VGF release from a select group of nociceptors.
Localization (release) of VGF in nociceptors associated with nociceptor
1) Confidence 0.81 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.64 Pain Relevance 0.58
For VGF, the sections were blocked for 1 hr in TTBS (0.05 M Tris saline, pH7.4/0.3% Triton-X100) containing 3% normal rabbit serum (NRS) at room temperature and incubated at 4°C for 72 hr with goat ?
Neg (blocked) Localization (blocked) of VGF
2) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.11 Pain Relevance 0.23
The colocalization of VGF with peptidergic primary afferents, in agreement with previous reports in culture [10], suggests depolarisation and neurotrophin mediated VGF release from a select group of nociceptors.
Localization (colocalization) of VGF in nociceptors associated with nociceptor
3) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.76 Pain Relevance 0.65
Other compounds recently identified that facilitate penile erection by activating central oxytocinergic neurons are peptide analogues of hexarelin, a growth hormone releasing peptide, pro-VGF-derived peptides, endogenous peptides that may be released by neuronal nerve endings impinging on oxytocinergic cell bodies, SR 141716A, a cannabinoid CB1 receptor antagonist, and, less convincingly, adrenocorticotropin-melanocyte-stimulating hormone (ACTH-MSH)-related peptides.
Localization (released) of VGF in melanocyte associated with erectile dysfunction, antagonist and cannabinoid
4) Confidence 0.73 Published 2005 Journal Prog. Neurobiol. Section Abstract Doc Link 16043278 Disease Relevance 0.39 Pain Relevance 0.54
The present results show for the first time that certain pro-VGF C-terminus-derived peptides promote penile erection when injected into the paraventricular nucleus and suggest that, within this nucleus, these or closely related pro-VGF-derived peptides may be released to influence sexual function by activating paraventricular oxytocinergic neurons mediating penile erection.
Localization (released) of VGF in nucleus associated with erectile dysfunction
5) Confidence 0.62 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579158 Disease Relevance 0.45 Pain Relevance 0.06

General Comments

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