INT123593

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 58
Total Number 92
Disease Relevance 35.76
Pain Relevance 12.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) histone binding (Snca)
plasma membrane (Snca) cytoskeleton (Snca) nucleus (Snca)
Anatomy Link Frequency
brain 10
striatum 5
cortex 5
hippocampus 3
dentate gyrus 2
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 825 99.84 Very High Very High Very High
Hippocampus 516 99.68 Very High Very High Very High
Morphine 16 99.62 Very High Very High Very High
Dopamine 382 99.16 Very High Very High Very High
withdrawal 16 99.12 Very High Very High Very High
alcohol 64 99.04 Very High Very High Very High
Inflammatory response 51 97.40 Very High Very High Very High
amygdala 24 97.16 Very High Very High Very High
opiate 20 96.76 Very High Very High Very High
monoamine 8 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 997 100.00 Very High Very High Very High
Toxicity 360 100.00 Very High Very High Very High
Parkinson's Disease 796 99.90 Very High Very High Very High
Disease 2533 99.72 Very High Very High Very High
Sprains And Strains 34 99.58 Very High Very High Very High
Stress 589 99.20 Very High Very High Very High
Anxiety Disorder 40 99.20 Very High Very High Very High
Apoptosis 56 98.64 Very High Very High Very High
Dementia 80 98.32 Very High Very High Very High
Death 144 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Utilizing a mouse SNCA specific probe, we determined if the knockdown of SNCA expression extended beyond the CA1 cannulation site (Figure 2).
Gene_expression (expression) of SNCA
1) Confidence 0.78 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.08 Pain Relevance 0.19
Taken together, this provides compelling evidence that SNCA overexpression can result in Lewy body parkinsonism and dementia.
Gene_expression (overexpression) of SNCA in body associated with parkinson's disease and dementia
2) Confidence 0.78 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 1.32 Pain Relevance 0.08
Quantitative RT-PCR analysis demonstrated that SNCA expression was significantly decreased in the right (treated) hippocampus of animals which have received SNCA siRNA when compared to the left (untreated) hippocampus (p = 0.037) as demonstrated by the R:L ratio of SNCA expression.
Gene_expression (expression) of SNCA in hippocampus associated with hippocampus
3) Confidence 0.78 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0 Pain Relevance 0.13
Additionally, the SNCA-specific siRNA reduced SNCA expression when compared to luciferase-siRNA (p = 0.004) and PBS (p = 0.036) treated control mice (Figure 1).
Gene_expression (expression) of SNCA
4) Confidence 0.78 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0 Pain Relevance 0.13
The Wilcoxon signed rank sum test was used to test whether the median right/left (R:L) ratio of SNCA expression from quantitative RT-PCR differed from 1.
Gene_expression (expression) of SNCA
5) Confidence 0.78 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0 Pain Relevance 0
Although SNCA expression was significantly reduced in the SNCA siRNA treated hippocampi, we hypothesized that the efficacy of the siRNA in the brain might be underestimated due to partial diffusion of the siRNA into the contralateral hippocampus.
Gene_expression (expression) of SNCA in brain associated with hippocampus
6) Confidence 0.78 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0 Pain Relevance 0.13
In order to test the ability of naked siRNA to reduce SNCA expression in vivo, we identified the hippocampus and the cortex as having the highest expression of SNCA in the murine brain (data not shown).
Gene_expression (expression) of SNCA in brain associated with hippocampus
7) Confidence 0.78 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0 Pain Relevance 0.09
We subsequently chose to target siRNA against SNCA expression in the hippocampus to decrease variability in our measurements that could be introduced when dissecting out smaller, less defined structures.
Gene_expression (expression) of SNCA in hippocampus associated with hippocampus
8) Confidence 0.78 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0 Pain Relevance 0.10
Quantitative RT-PCR analysis demonstrated that SNCA expression was significantly decreased in the right (treated) hippocampus of animals which have received SNCA siRNA when compared to the left (untreated) hippocampus (p = 0.037) as demonstrated by the R:L ratio of SNCA expression.
Gene_expression (expression) of SNCA in hippocampus associated with hippocampus
9) Confidence 0.78 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0 Pain Relevance 0.15
The present study investigated the influence of acute and chronic morphine administration on alpha-synuclein mRNA and protein expression in the brains of mice.
Gene_expression (expression) of alpha-synuclein mRNA in brains associated with morphine
10) Confidence 0.78 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901780 Disease Relevance 0 Pain Relevance 0.83
Regulation of alpha-synuclein expression in limbic and motor brain regions of morphine-treated mice.
Gene_expression (expression) of alpha-synuclein in brain associated with morphine
11) Confidence 0.78 Published 2005 Journal J. Neurosci. Section Title Doc Link 15901780 Disease Relevance 0 Pain Relevance 0.79
The aim of our study was to characterize the changes in alpha-synuclein expression after short-term abstinence from chronic alcohol drinking in mice.
Gene_expression (expression) of alpha-synuclein associated with alcohol
12) Confidence 0.78 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18456291 Disease Relevance 0.17 Pain Relevance 0.40
alpha-Synuclein expression in the brain and blood during abstinence from chronic alcohol drinking in mice.
Gene_expression (expression) of alpha-Synuclein in brain associated with alcohol
13) Confidence 0.78 Published 2008 Journal Neuropharmacology Section Title Doc Link 18456291 Disease Relevance 0.15 Pain Relevance 0.38
Although alpha-synuclein expression in the blood seems unrelated to that in the brain, it may serve as a peripheral biomarker of chronic alcohol consumption.
Gene_expression (expression) of alpha-synuclein in blood associated with alcohol
14) Confidence 0.78 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18456291 Disease Relevance 0.15 Pain Relevance 0.80
Alpha-synuclein was detected in both, neurons and the neuropil, however only in treated animals the staining of neural processes was visible (Figure 3F).
Gene_expression (detected) of Alpha-synuclein in neurons
15) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.12 Pain Relevance 0.06
We detected alpha-synuclein in ENS neurons from the duodenum and ileum of both control and treated animals.
Gene_expression (detected) of alpha-synuclein in ileum
16) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.19 Pain Relevance 0.05
It is possible that upregulation of DAT expression in the remaining DA terminals of SNCA overexpressing mice might mask the loss of dopaminergic terminals by this measure, though it also is possible that a difference would have been revealed with a larger number of mice in each group.
Gene_expression (overexpressing) of SNCA
17) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.31 Pain Relevance 0.03
Other in vivo work also demonstrates that the selective expression of SNCA (in this case the A53T mutant) in astrocytes leads to increased inflammatory responses and microglial activation resulting in significant dopaminergic cell loss [53].
Gene_expression (expression) of SNCA in astrocytes associated with inflammatory response
18) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.59 Pain Relevance 0.14
We tested for a causal relationship between the two findings by employing B6N (expressing alpha-synuclein), B6JOla (not expressing alpha-syn) and the third strain C57BL/6JCrl (B6Jax, expressing alpha-syn).
Neg (not) Gene_expression (expressing) of alpha-syn associated with sprains and strains
19) Confidence 0.75 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15639180 Disease Relevance 0.84 Pain Relevance 0.06
We tested for a causal relationship between the two findings by employing B6N (expressing alpha-synuclein), B6JOla (not expressing alpha-syn) and the third strain C57BL/6JCrl (B6Jax, expressing alpha-syn).
Gene_expression (expressing) of alpha-syn associated with sprains and strains
20) Confidence 0.75 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15639180 Disease Relevance 0.91 Pain Relevance 0.06

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