INT123594

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 4.43
Pain Relevance 4.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) histone binding (Snca)
plasma membrane (Snca) cytoskeleton (Snca) nucleus (Snca)
Anatomy Link Frequency
dentate gyrus 2
cortex 2
nucleus accumbens 1
brain 1
striatum 1
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 295 99.44 Very High Very High Very High
amygdala 9 98.68 Very High Very High Very High
Nucleus accumbens 3 97.60 Very High Very High Very High
Dopamine 37 96.80 Very High Very High Very High
Ventral tegmentum 3 96.68 Very High Very High Very High
Morphine 12 96.56 Very High Very High Very High
Substantia nigra 76 95.04 Very High Very High Very High
opiate 9 93.00 High High
adenocard 2 91.76 High High
depression 1 90.16 High High
Disease Link Frequency Relevance Heat
Disease 326 98.28 Very High Very High Very High
Targeted Disruption 44 93.64 High High
Stress 12 93.52 High High
Dementia 42 92.56 High High
Parkinson's Disease 130 91.60 High High
Hypoxia 1 91.24 High High
Depression 1 90.16 High High
INFLAMMATION 16 82.00 Quite High
Alzheimer's Dementia 28 76.80 Quite High
Cognitive Disorder 14 64.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these observations indicate that the loss of alpha-Syn reduces synaptic efficacy when the probability of transmitter release is modified.
Negative_regulation (loss) of alpha-Syn
1) Confidence 0.59 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579163 Disease Relevance 0.51 Pain Relevance 0.28
Downregulation of alpha-synuclein mRNA was observed in the basolateral amygdala, dorsal striatum, nucleus accumbens, and ventral tegmental area of mice withdrawn from chronic morphine treatment.
Negative_regulation (Downregulation) of alpha-synuclein mRNA in ventral associated with ventral tegmentum, nucleus accumbens, amygdala and morphine
2) Confidence 0.59 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901780 Disease Relevance 0 Pain Relevance 0.85
Significant reductions in SNCA levels were observed in the CA1 (66%, p < 0.001), CA2 (59%, p < 0.001), CA3 (77%, p < 0.001), and dentate gyrus (81%, p = 0.001) when SNCA siRNA treated animals were compared to PBS treated animals.
Negative_regulation (reductions) of SNCA in dentate gyrus
3) Confidence 0.51 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.07 Pain Relevance 0.10
SNCA levels in the right CA1 (Figure 3A), the site of injection, remained noticeably reduced when compared to the uninjected control side through three weeks post-infusion.
Negative_regulation (reduced) of SNCA
4) Confidence 0.51 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.08 Pain Relevance 0.10
The least reduction in SNCA levels, shown as a reduction in right (R):left (L) ratio, was observed in the cortex (71% between PBS and SNCA siRNA treated animals, p = 0.067), likely reflecting the fact that the cortex spans from regions adjacent to the infusion site to regions quite distant from the infusion site and thus less likely to be affected by the siRNA.
Negative_regulation (reduction) of SNCA in cortex
5) Confidence 0.51 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.08 Pain Relevance 0.12
We then injected them into the Cornu Ammonis (CA1) of the hippocampus of mice and demonstrated a reduction in SNCA mRNA levels by quantitative reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization throughout the hippocampus and cortex.
Negative_regulation (reduction) of SNCA in cortex associated with hippocampus
6) Confidence 0.43 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.42 Pain Relevance 0.10
Although SNCA expression was significantly reduced in the SNCA siRNA treated hippocampi, we hypothesized that the efficacy of the siRNA in the brain might be underestimated due to partial diffusion of the siRNA into the contralateral hippocampus.
Negative_regulation (reduced) of SNCA in brain associated with hippocampus
7) Confidence 0.43 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0 Pain Relevance 0.13
Hence therapy aimed at reducing SNCA expression levels may provide therapeutic benefit for patients with either familial or idiopathic PD.
Negative_regulation (reducing) of SNCA associated with disease
8) Confidence 0.43 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.99 Pain Relevance 0.07
Therefore it is feasible that direct antioxidant effects of NAC may have reduced levels of SNCA protein.
Negative_regulation (reduced) of SNCA protein
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.49 Pain Relevance 0.22
This analysis of SNCB is particularly important in demonstrating the specificity of the SNCA siRNA silencing, and in showing that an increase in SNCB expression does not compensate for a reduction in its homologue, SNCA.
Negative_regulation (reduction) of SNCA
10) Confidence 0.38 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.24 Pain Relevance 0.26
Additionally, similar SNCA reductions were observed in the right CA2, CA3, and dentate gyrus of mice treated with SNCA siRNA (data not shown).
Negative_regulation (reductions) of SNCA in dentate gyrus
11) Confidence 0.38 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0 Pain Relevance 0.03
SNCA downregulation is therefore a valid therapeutic target for PD.


Negative_regulation (downregulation) of SNCA associated with disease
12) Confidence 0.38 Published 2008 Journal Mol Neurodegener Section Abstract Doc Link PMC2612658 Disease Relevance 0.57 Pain Relevance 0.08
Reduction in SNCA levels was confirmed by immunostaining for murine ?
Negative_regulation (Reduction) of SNCA
13) Confidence 0.38 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.05 Pain Relevance 0.10
In order to address this issue, we endeavored to examine the distribution of SNCA knockdown by in situ hybridization so that the extent of SNCA reduction could be fully appreciated.
Negative_regulation (reduction) of SNCA
14) Confidence 0.38 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.07 Pain Relevance 0.18
To exploit the therapeutic potential of siRNA, we developed naked siRNA molecules against SNCA that are resistant to endo- and exonuclease activity in serum and yield species-specific reduction of SNCA in vitro.
Negative_regulation (reduction) of SNCA
15) Confidence 0.38 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.43 Pain Relevance 0.09
Specific in vivo knockdown of murine SNCA
Negative_regulation (knockdown) of SNCA
16) Confidence 0.37 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0 Pain Relevance 0.09
Downregulation of alpha-synuclein mRNA was observed in the basolateral amygdala, dorsal striatum, nucleus accumbens, and ventral tegmental area of mice withdrawn from chronic morphine treatment.
Negative_regulation (Downregulation) of alpha-synuclein mRNA in striatum associated with ventral tegmentum, nucleus accumbens, amygdala and morphine
17) Confidence 0.20 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901780 Disease Relevance 0 Pain Relevance 0.85
Downregulation of alpha-synuclein mRNA was observed in the basolateral amygdala, dorsal striatum, nucleus accumbens, and ventral tegmental area of mice withdrawn from chronic morphine treatment.
Negative_regulation (Downregulation) of alpha-synuclein mRNA in nucleus accumbens associated with ventral tegmentum, nucleus accumbens, amygdala and morphine
18) Confidence 0.20 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901780 Disease Relevance 0 Pain Relevance 0.85
We then injected them into the Cornu Ammonis (CA1) of the hippocampus of mice and demonstrated a reduction in SNCA mRNA levels by quantitative reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization throughout the hippocampus and cortex.
Negative_regulation (reduction) of SNCA in hippocampus associated with hippocampus
19) Confidence 0.15 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.42 Pain Relevance 0.10

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