INT123595

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 4.30
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) histone binding (Snca)
plasma membrane (Snca) cytoskeleton (Snca) nucleus (Snca)
Anatomy Link Frequency
pyramidal neurons 1
neurons 1
brains 1
mesencephalon 1
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 8 100.00 Very High Very High Very High
Pyramidal cell 5 99.68 Very High Very High Very High
Spinal cord 32 99.64 Very High Very High Very High
amygdala 9 99.40 Very High Very High Very High
alcohol 11 99.12 Very High Very High Very High
projection neuron 4 98.28 Very High Very High Very High
opiate 8 98.00 Very High Very High Very High
Dopamine 30 94.84 High High
withdrawal 6 94.64 High High
Serotonin 4 94.12 High High
Disease Link Frequency Relevance Heat
Disease 251 100.00 Very High Very High Very High
Urological Neuroanatomy 24 99.64 Very High Very High Very High
Rhinitis 2 99.60 Very High Very High Very High
Toxicity 15 99.28 Very High Very High Very High
Parkinson's Disease 113 99.26 Very High Very High Very High
Convulsion 53 97.56 Very High Very High Very High
Alcohol Addiction 3 89.00 High High
Alzheimer's Dementia 2 87.36 High High
Dementia 5 86.56 High High
Multiple System Atrophy 5 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have investigated the excitatory synaptic modulation of alpha-synuclein in CA1 pyramidal neurons, using the in vitro hippocampal slice technique.
Spec (investigated) Regulation (modulation) of alpha-synuclein in pyramidal neurons associated with pyramidal cell
1) Confidence 0.62 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579163 Disease Relevance 0.55 Pain Relevance 0.15
The observed changes in alpha-synuclein levels are discussed in connection with their putative role in mediating suppression of dopaminergic neurotransmission during opiate withdrawal.
Regulation (changes) of alpha-synuclein associated with opiate and withdrawal
2) Confidence 0.62 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901780 Disease Relevance 0 Pain Relevance 0.70
However, the potential participation of alpha-synuclein in maintaining and regulating synaptic efficacy is unknown.
Regulation (regulating) of alpha-synuclein
3) Confidence 0.45 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579163 Disease Relevance 0.50 Pain Relevance 0.13
As in the earlier studies, we saw no impact of SNCA siRNA on the levels of SNCB at any timepoint (Figure 3).
Neg (no) Regulation (impact) of SNCA
4) Confidence 0.45 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.09 Pain Relevance 0.12
The present study investigated the influence of acute and chronic morphine administration on alpha-synuclein mRNA and protein expression in the brains of mice.
Spec (investigated) Regulation (influence) of alpha-synuclein mRNA in brains associated with morphine
5) Confidence 0.45 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15901780 Disease Relevance 0 Pain Relevance 0.83
No changes in alpha-synuclein levels were found in the mesencephalon or striatum/accumbens.
Neg (No) Regulation (changes) of alpha-synuclein in mesencephalon
6) Confidence 0.45 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18456291 Disease Relevance 0.24 Pain Relevance 0.82
With any of the seizure paradigms, it is plausible that reduced synaptic efficacy, e.g., due to reduced expression of the other three candidates singled out—Syn2, Nsf, or Snca—is the other contributing variable.
Regulation (singled) of Snca associated with convulsion
7) Confidence 0.38 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.29 Pain Relevance 0.12
In this way, microtubule impairment affects alpha-synuclein distribution and toxicity and also may be responsible for mitochondria synaptic depletion, consistent with the “dying back” phenomenon of DAergic neurons degeneration (Figure 1).
Regulation (affects) of alpha-synuclein in neurons associated with toxicity
8) Confidence 0.33 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.52 Pain Relevance 0
We then examined whether there were alpha-synuclein PD-like alterations in ENS, IML, DMV or the SN and if these alterations were progressive.


Regulation (alterations) of alpha-synuclein associated with disease and spinal cord
9) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.20 Pain Relevance 0.05
LBs are eosinophilic intracytoplasmatic aggregates of several proteins such as alpha-synuclein, ubiquitin, synphilin-1, 14-3-3 protein, tubulin and other cytoskeletal proteins (Forno, 1996).
Regulation (aggregates) of alpha-synuclein associated with parkinson's disease and rhinitis
10) Confidence 0.24 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 1.92 Pain Relevance 0.13

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