INT12360

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Context Info
Confidence 0.61
First Reported 1981
Last Reported 2009
Negated 11
Speculated 7
Reported most in Abstract
Documents 31
Total Number 41
Disease Relevance 5.90
Pain Relevance 18.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
striatum 6
platelet 2
hypothalamus 2
caudate nucleus 1
caudate-putamen 1
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 119 100.00 Very High Very High Very High
substance P 101 100.00 Very High Very High Very High
Enkephalin 62 100.00 Very High Very High Very High
Serotonin 15 100.00 Very High Very High Very High
Cholecystokinin 12 100.00 Very High Very High Very High
dopamine receptor 7 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
anesthesia 6 100.00 Very High Very High Very High
Pain 4 100.00 Very High Very High Very High
Spinal cord 3 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 9 100.00 Very High Very High Very High
Parkinson's Disease 27 98.48 Very High Very High Very High
Dyskinesias 24 98.08 Very High Very High Very High
Pressure And Volume Under Development 3 94.68 High High
Urological Neuroanatomy 2 94.32 High High
Respiratory Disease 5 90.52 High High
Asthma 25 88.56 High High
INFLAMMATION 25 85.68 High High
Weight Gain 4 85.24 High High
Disease 5 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevation of circulating corticosterone levels in intact rats by acute restraint stress, or by corticosterone injection did not change the level of PPT mRNA in the striatum.
Neg (not) Regulation (change) of PPT mRNA in striatum associated with stress
1) Confidence 0.61 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1645434 Disease Relevance 0.10 Pain Relevance 0.04
The results demonstrate that the PPT mRNA is regulated by glucocorticoids such that adrenalectomized (ADX) animals replaced with corticosterone for 5 days expressed higher levels of the mRNA than ADX animals.
Regulation (regulated) of PPT mRNA
2) Confidence 0.61 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1645434 Disease Relevance 0.07 Pain Relevance 0.04
The effects of lowered serotonin (5-hydroxytryptamine; 5-HT) neurotransmission on preprotachykinin (PPT) and preproenkephalin (PPE) mRNA levels were examined in subregions of the striatum.
Spec (examined) Regulation (effects) of PPT in striatum associated with serotonin
3) Confidence 0.57 Published 1996 Journal Brain Res. Section Abstract Doc Link 8891265 Disease Relevance 0 Pain Relevance 0.12
Although these results support previous studies suggesting an overall positive regulatory role of serotonin on striatal tachykinin biosynthesis, PPT and PPE gene regulation in certain striatal subregions may by differentially sensitive to lowered 5-HT neurotransmission.
Regulation (regulation) of PPT associated with serotonin
4) Confidence 0.57 Published 1996 Journal Brain Res. Section Abstract Doc Link 8891265 Disease Relevance 0 Pain Relevance 0.19
In the intact rat, DOI did not influence PPT mRNA levels in the rostral striatum, but did raise expression in the caudal striatum where 5-HT2A receptors are prominent.
Neg (not) Regulation (influence) of PPT mRNA in striatum
5) Confidence 0.41 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11483243 Disease Relevance 0 Pain Relevance 0.55
The tachykinin neurokinin 1 receptors (NK(1)Rs) regulation of acetylcholine release and its interaction with the enkephalin/mu opioid receptors (MORs) transmission was investigated in the limbic/prefrontal (PF) territory of the dorsal striatum.
Regulation (regulation) of tachykinin in prefrontal associated with mu opioid receptor and enkephalin
6) Confidence 0.39 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17949415 Disease Relevance 0 Pain Relevance 0.37
Effects of space flight stress on proopiomelanocortin, proenkephalin A, and tachykinin neuropeptidergic systems in the rat posterior pituitary.
Regulation (Effects) of tachykinin in posterior pituitary associated with stress and enkephalin
7) Confidence 0.34 Published 1994 Journal Life Sci. Section Title Doc Link 7518553 Disease Relevance 0.18 Pain Relevance 0.46
We determined proenkephalin and protachykinin mRNA levels in the striatum of the rat by in situ hybridization histochemistry in controls and in animals treated for 14 days with the potential neuroleptic drug BMY 14802 (15 mg/kg i.p.).
Spec (determined) Regulation (determined) of protachykinin mRNA in striatum
8) Confidence 0.32 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1968844 Disease Relevance 0 Pain Relevance 0
Selective tachykinin NK1 receptor antagonists administered systemically did not result in substantial locus coeruleus c-fos expression.
Neg (not) Regulation (result) of tachykinin in locus coeruleus associated with locus ceruleus and antagonist
9) Confidence 0.30 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652329 Disease Relevance 0.33 Pain Relevance 0.51
These findings suggest that tachykinins acting on NK2 receptors play a role in the modulation of the spontaneous mechanical activity.
Regulation (acting) of tachykinin
10) Confidence 0.26 Published 2000 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 11012946 Disease Relevance 0 Pain Relevance 0.45
Dopaminergic regulation of striatonigral tachykinin and dynorphin gene expression: a study with the dopamine uptake inhibitor GBR-12909.
Regulation (regulation) of tachykinin associated with dopamine, dynorphin and enkephalin
11) Confidence 0.24 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.60
We have investigated the effect of dopamine receptor blockade on striatal proenkephalin mRNA and protachykinin mRNA by Northern gel analysis and by in situ hybridization histochemistry.
Spec (investigated) Regulation (effect) of protachykinin associated with dopamine receptor
12) Confidence 0.24 Published 1987 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3434462 Disease Relevance 0 Pain Relevance 0.16
The pharmacological profile of the tachykinin NK(1)R regulation tested by application of the receptor agonists [[Pro(9)]substance P, neurokinin A, neuropeptide K, and substance P(6-11)] and antagonists (SSR240600, GR205171, GR82334, and RP67580) indicated that the subtype of tachykinin NK(1)R implicated are the new NK(1)-sensitive receptor binding site.
Regulation (regulation) of tachykinin associated with antagonist, neuropeptide, agonist and substance p
13) Confidence 0.23 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17949415 Disease Relevance 0 Pain Relevance 0.86
The changes in mRNA levels for protachykinin and proenkephalin were uniform throughout the caudate-putamen of the rat as determined by in situ hybridization histochemistry.
Regulation (changes) of protachykinin in caudate-putamen
14) Confidence 0.18 Published 1987 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3434462 Disease Relevance 0 Pain Relevance 0.16
The data suggest that sigma receptor activity, directly or indirectly, affects proenkephalin and protachykinin mRNA expression in striatal neurons.
Regulation (affects) of protachykinin mRNA in neurons
15) Confidence 0.16 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1968844 Disease Relevance 0 Pain Relevance 0
The present study was designed to determine if increased 5-HT release from sprouted terminals influences dysregulated preprotachykinin (PPT) and preproenkephalin (PPE) mRNA expression in the DA-depleted STR.
Regulation (dysregulated) of PPT in STR associated with dopamine
16) Confidence 0.16 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000480 Disease Relevance 0 Pain Relevance 0.59
In the ipsilateral L1/L2 dorsal horn, CGRP and tachykinin, but not galanin, immunoreactivity was reduced.
Regulation (immunoreactivity) of tachykinin in dorsal horn associated with dorsal horn
17) Confidence 0.14 Published 1990 Journal Brain Res. Section Abstract Doc Link 1693868 Disease Relevance 0.15 Pain Relevance 0.25
Tetrapeptide tachykinin antagonists: synthesis and modulation of the physicochemical and pharmacological properties of a new series of partially cyclic analogs.
Regulation (modulation) of tachykinin associated with analgesic and antagonist
18) Confidence 0.12 Published 1993 Journal J. Med. Chem. Section Title Doc Link 8388471 Disease Relevance 0 Pain Relevance 0.34
The present investigation examined the effects of neonatal and adult 6-hydroxydopamine (6-OHDA)-induced lesions of dopaminergic neurons on opioid and tachykinin peptides and their gene expression in the rat basal ganglia.
Spec (examined) Regulation (effects) of tachykinin in dopaminergic neurons associated with opioid
19) Confidence 0.11 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 2889804 Disease Relevance 0 Pain Relevance 0.54
These findings suggest the involvement of tachykinin NK2, CGRP and non-NMDA receptor systems in the vanilloid VR1 receptor-mediated regulation of gastric acid secretion in the rat brain regions close to the lateral cerebroventricle.
Regulation (involvement) of tachykinin in lateral associated with nmda receptor and calcitonin gene-related peptide
20) Confidence 0.11 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14985054 Disease Relevance 0 Pain Relevance 0.58

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