INT123626

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.88
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
PMN 1
Tnni1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 21 99.64 Very High Very High Very High
Inflammation 36 92.64 High High
anesthesia 7 91.68 High High
ischemia 60 80.72 Quite High
antagonist 16 73.16 Quite High
agonist 3 69.32 Quite High
imagery 3 33.52 Quite Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Kinase C inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3 99.98 Very High Very High Very High
Death 12 93.76 High High
Myocarditis 6 92.64 High High
Neutropenia 27 88.04 High High
Injury 111 87.20 High High
Cv Unclassified Under Development 48 80.72 Quite High
Congenital Anomalies 1 75.04 Quite High
Coronary Artery Disease 21 75.00 Quite High
INFLAMMATION 36 47.96 Quite Low
Reperfusion Injury 3 42.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We studied pressure-volume loops in transgenic mice expressing mutant troponin I lacking protein kinase C phosphorylation sites and hypothesized altered responses to phenylephrine.
Gene_expression (expressing) of troponin I associated with targeted disruption and kinase c
1) Confidence 0.43 Published 2005 Journal J. Appl. Physiol. Section Abstract Doc Link 15579573 Disease Relevance 0.17 Pain Relevance 0.32
Indeed, recently we have shown that in a transgenic mouse expressing mutant troponin I lacking protein kinase C phosphorylation sites that during high perfusate calcium inotropy that there is a significant elevation in the ratio of developed pressure to myocardial oxygen consumption relative to wild type controls [13].
Gene_expression (expressing) of mutant troponin I associated with targeted disruption and kinase c
2) Confidence 0.10 Published 2001 Journal BMC Physiol Section Body Doc Link PMC55339 Disease Relevance 0.10 Pain Relevance 0.30
Serum troponin I concentrations
Gene_expression (concentrations) of troponin I
3) Confidence 0.05 Published 2010 Journal GMS German Medical Science Section Body Doc Link PMC2940219 Disease Relevance 0.44 Pain Relevance 0.07
Results: In wild type mice, MI/R significantly decrease myocardial ejection fraction and increased serum troponin I levels and myocardial PMN infiltration compared to sham-operated animals.
Gene_expression (levels) of troponin I in PMN
4) Confidence 0.05 Published 2010 Journal GMS German Medical Science Section Abstract Doc Link PMC2940219 Disease Relevance 1.02 Pain Relevance 0.15
Serum troponin I concentrations
Gene_expression (concentrations) of troponin I
5) Confidence 0.05 Published 2010 Journal GMS German Medical Science Section Body Doc Link PMC2940219 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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