INT123643

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 1.85
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Reln) extracellular space (Reln) extracellular region (Reln)
cell adhesion (Reln) proteinaceous extracellular matrix (Reln) cytoplasm (Reln)
Anatomy Link Frequency
radial 3
neurons 3
neuronal 2
brain 2
Cajal-Retzius cells 1
Reln (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid receptor 1 1 99.56 Very High Very High Very High
Glutamate receptor 1 98.76 Very High Very High Very High
Pain 3 97.88 Very High Very High Very High
Pyramidal cell 15 93.52 High High
Spinal cord 3 93.48 High High
Dorsal horn 3 93.00 High High
nMDA receptor 5 91.84 High High
Hippocampus 11 77.96 Quite High
cerebral cortex 58 73.80 Quite High
gABA 39 70.96 Quite High
Disease Link Frequency Relevance Heat
Aggression 8 98.12 Very High Very High Very High
Disease 34 86.28 High High
Fibrosarcoma 1 86.00 High High
Disseminated Intravascular Coagulation 110 83.92 Quite High
Disorder Of Lipid Metabolism 16 83.56 Quite High
Stress 2 77.28 Quite High
Nociception 2 75.00 Quite High
Malformations Of Cortical Development 77 65.56 Quite High
Injury 12 63.20 Quite High
Cancer 37 61.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is important to note that reelin is not an ideal marker of CR neurons because, although all CR neurons express reelin, reelin is also expressed in many other cortical cells, not just in L1 (Alcantara et al., 1998; Meyer et al., 1998).
Neg (not) Gene_expression (expressed) of reelin in neurons
1) Confidence 0.75 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0 Pain Relevance 0.16
Later in development, other cells appear in L1 that express reelin but do not express GFP, but they have a very different morphology.
Gene_expression (express) of reelin
2) Confidence 0.75 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0 Pain Relevance 0.06
It is important to note that reelin is not an ideal marker of CR neurons because, although all CR neurons express reelin, reelin is also expressed in many other cortical cells, not just in L1 (Alcantara et al., 1998; Meyer et al., 1998).
Gene_expression (express) of reelin in neurons
3) Confidence 0.75 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2845061 Disease Relevance 0 Pain Relevance 0.16
We used immunocytochemistry to map the distribution of Reelin and Disabled-1 (the protein product of the reeler gene, and the intracellular adaptor protein, Dab1, involved in its signaling pathway) in adjacent regions of the developing dorsal horn, from early to late embryonic development.
Gene_expression (distribution) of Reelin in dorsal horn associated with dorsal horn
4) Confidence 0.67 Published 2006 Journal Neuroscience Section Abstract Doc Link 16580148 Disease Relevance 0.07 Pain Relevance 0.30
In SI male mice, aggression can be prevented by treatment with L-methionine (MET), which has also been shown to decrease reelin and GAD67 mRNA expression and maintain normal brain Allo content.
Gene_expression (expression) of reelin in brain associated with aggression
5) Confidence 0.65 Published 2004 Journal Crit Rev Neurobiol Section Abstract Doc Link 15581402 Disease Relevance 0.66 Pain Relevance 0.07
VLDLR and ApoER2 transduce signals from the extracellular matrix molecule Reelin, affecting neuronal cell migration during development [83].
Gene_expression (transduce) of Reelin in neuronal
6) Confidence 0.29 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0.05
Another interesting finding is that the highly polarized morphology of radial glia is restored whether the source of reelin is focal or diffuse.
Gene_expression (source) of reelin in radial
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
In MAM treated brains, Cajal-Retzius cells expressing reelin are highly disorganized [21].
Gene_expression (expressing) of reelin in Cajal-Retzius cells
8) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.07 Pain Relevance 0
In addition to radial process extension, reelin and NRG1 promote expression of Brain Lipid Binding Protein (BLBP) in cortical radial glia [40], [41], [32].
Gene_expression (expression) of reelin in radial
9) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.14 Pain Relevance 0.04
ApoER2 and VLDLR exhibit overlapping but also distinct functions in the transduction of the reelin signaling [48].
Gene_expression (transduction) of reelin
10) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
A number of MAM treated slices were co-cultured with: (1) HEK 293T cells, transfected with the mouse reelin cDNA construct pCrl [43], which produces and secretes the full length reelin protein [44], [39], (2) HEK 293T cells, transfected with the type I NRG1 encoding plasmid (NRG1-Ig), which secretes the full length of the isoform type I NRG1 [45] and (3) HEK 293T cells, transfected with the type III NRG1 (NRG1-CRD), which express a non-secreted/membrane type III NRG1 [45].
Gene_expression (produces) of reelin
11) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.08 Pain Relevance 0.03
In our model, BLBP-positive radial glia, although substantially less disrupted, were not significantly altered when slices were exposed to reelin or NRG1.
Gene_expression (exposed) of reelin in radial
12) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.17 Pain Relevance 0.07
To create a focal and normotopic source of reelin, MAM slices were co-cultured with reelin-secreting HEK cells included in Matrigel and placed at the pial surface [39] (Figure 4a–c).
Gene_expression (source) of reelin
13) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.05 Pain Relevance 0
We previously demonstrated that an exogenous source of reelin placed at the pial surface was sufficient to restore the radial glial scaffold and neuronal migration toward the cortical plate [39].
Gene_expression (source) of reelin in neuronal
14) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.07 Pain Relevance 0
To assess the effect of a diffuse source of reelin, MAM treated slices were incubated in medium containing recombinant reelin (1 nM) or plain medium as a control.
Gene_expression (source) of reelin
15) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
A number of MAM treated slices were co-cultured with: (1) HEK 293T cells, transfected with the mouse reelin cDNA construct pCrl [43], which produces and secretes the full length reelin protein [44], [39], (2) HEK 293T cells, transfected with the type I NRG1 encoding plasmid (NRG1-Ig), which secretes the full length of the isoform type I NRG1 [45] and (3) HEK 293T cells, transfected with the type III NRG1 (NRG1-CRD), which express a non-secreted/membrane type III NRG1 [45].
Gene_expression (produces) of reelin
16) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.08 Pain Relevance 0.03
In the absence of Ctip2, MSN do not fully differentiate, as demonstrated by dramatically reduced expression of a large number of MSN markers, including DARPP-32, FOXP1, Chrm4, Reelin, MOR1 (mu-opioid receptor 1), glutamate receptor 1, and Plexin-D1.
Gene_expression (expression) of Reelin in MSN associated with glutamate receptor and opioid receptor 1
17) Confidence 0.08 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18199763 Disease Relevance 0.09 Pain Relevance 0.15
In MAM treated brains, Cajal-Retzius cells expressing reelin are highly disorganized [21].
Gene_expression (expressing) of reelin in brains
18) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.07 Pain Relevance 0
At the molecular level, this switch could be linked to two main changes: the decrease in the expression of matrix protease genes and the reduced expression of the Rho GTP-binding protein Rnd3.
Gene_expression (expression) of matrix protease
19) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.29 Pain Relevance 0

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