INT123644

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Reln) extracellular space (Reln) extracellular region (Reln)
cell adhesion (Reln) proteinaceous extracellular matrix (Reln) cytoplasm (Reln)
Anatomy Link Frequency
brain 2
Reln (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 1 69.20 Quite High
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aggression 8 98.30 Very High Very High Very High
Fibrosarcoma 1 86.64 High High
Stress 2 77.92 Quite High
Cancer 37 62.04 Quite High
Sarcoma 14 61.04 Quite High
Malignant Neoplastic Disease 5 47.92 Quite Low
Skin Cancer 3 33.72 Quite Low
Carcinoma 4 33.20 Quite Low
Metastasis 16 30.12 Quite Low
Severe Combined Immunodeficiency 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In SI male mice, aggression can be prevented by treatment with L-methionine (MET), which has also been shown to decrease reelin and GAD67 mRNA expression and maintain normal brain Allo content.
Negative_regulation (decrease) of Gene_expression (expression) of reelin in brain associated with aggression
1) Confidence 0.41 Published 2004 Journal Crit Rev Neurobiol Section Abstract Doc Link 15581402 Disease Relevance 0.66 Pain Relevance 0.07
At the molecular level, this switch could be linked to two main changes: the decrease in the expression of matrix protease genes and the reduced expression of the Rho GTP-binding protein Rnd3.
Negative_regulation (decrease) of Gene_expression (expression) of matrix protease
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.29 Pain Relevance 0

General Comments

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