INT123645

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.76
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
brain 2
Gad1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 13 92.24 High High
Pyramidal cell 45 84.64 Quite High
fluoxetine 1 69.20 Quite High
nMDA receptor 72 62.72 Quite High
nMDA receptor antagonist 4 20.40 Low Low
Hippocampus 7 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Action potential 2 5.00 Very Low Very Low Very Low
long-term potentiation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aggression 8 98.30 Very High Very High Very High
Convulsion 30 95.52 Very High Very High Very High
Infection 5 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In SI male mice, aggression can be prevented by treatment with L-methionine (MET), which has also been shown to decrease reelin and GAD67 mRNA expression and maintain normal brain Allo content.
Negative_regulation (decrease) of Transcription (expression) of GAD67 in brain associated with aggression
1) Confidence 0.42 Published 2004 Journal Crit Rev Neurobiol Section Abstract Doc Link 15581402 Disease Relevance 0.66 Pain Relevance 0.07
0.08), while the level of GAD67 mRNA was slightly but significantly reduced in the mutant mice (P<0.001).
Negative_regulation (reduced) of Transcription (level) of GAD67
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.10 Pain Relevance 0.45

General Comments

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