INT123645

Context Info Confidence 0.42 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.76 Pain Relevance 0.52

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1) cytoplasm (Gad1)

Anatomy Link Frequency brain 2 Gad1 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate receptor 13 92.24 Pyramidal cell 45 84.64 fluoxetine 1 69.20 nMDA receptor 72 62.72 nMDA receptor antagonist 4 20.40 Hippocampus 7 5.00 ketamine 3 5.00 gABA 2 5.00 Action potential 2 5.00 long-term potentiation 1 5.00

Disease Link Frequency Relevance Heat Aggression 8 98.30 Convulsion 30 95.52 Infection 5 5.00 Sprains And Strains 3 5.00 Targeted Disruption 2 5.00 Congenital Anomalies 2 5.00 Generalized Anxiety Disorder 2 5.00 Increased Venous Pressure Under Development 2 5.00 Cytomegalovirus Infection 2 5.00 Epilepsy 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In SI male mice, aggression can be prevented by treatment with L-methionine (MET), which has also been shown to decrease reelin and GAD67 mRNA expression and maintain normal brain Allo content.

Negative_regulation (decrease) of Transcription (expression) of GAD67 in brain associated with aggression

1) Confidence 0.42 Published 2004 Journal Crit Rev Neurobiol Section Abstract Doc Link 15581402 Disease Relevance 0.66 Pain Relevance 0.07

0.08), while the level of GAD67 mRNA was slightly but significantly reduced in the mutant mice (P<0.001).

Negative_regulation (reduced) of Transcription (level) of GAD67

2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.10 Pain Relevance 0.45

General Comments

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