INT123660

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.96
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F2R) Golgi apparatus (F2R) plasma membrane (F2R)
signal transducer activity (F2R)
Anatomy Link Frequency
platelets 1
F2R (Homo sapiens)
PAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 1 89.64 High High
Inflammation 1 78.48 Quite High
agonist 1 60.48 Quite High
aspirin 6 57.36 Quite High
metalloproteinase 18 54.56 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 33 99.76 Very High Very High Very High
Prostate Cancer 87 99.40 Very High Very High Very High
Cv General 3 Under Development 1 89.64 High High
Acute Coronary Syndrome 3 88.44 High High
Atherosclerotic Plaque 1 82.04 Quite High
INFLAMMATION 1 78.48 Quite High
Benign Prostatic Hypertrophy 4 56.80 Quite High
Malignant Neoplastic Disease 6 25.20 Quite Low
Cancer 37 5.00 Very Low Very Low Very Low
Adhesions 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of protease-activated receptor 1 (PAR1; thrombin receptor) by thrombin may stimulate prostate cancer cells to secrete MMPs [11,24].
thrombin Positive_regulation (activation) of PAR1 associated with prostate cancer
1) Confidence 0.10 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 1.46 Pain Relevance 0.03
Treatment of platelets with thrombin (activates PAR1 and PAR4 thrombin receptors), SFLLRN (PAR1), AYPGKF (PAR4), collagen (alpha2beta1 and GPVI/FCgammaIIR receptors) and U46619 (TXA(2)) resulted in strong activation of p38 MAPK.
thrombin Positive_regulation (activates) of PAR1 in platelets
2) Confidence 0.07 Published 2004 Journal Thromb. Haemost. Section Abstract Doc Link 15583748 Disease Relevance 0.51 Pain Relevance 0.19

General Comments

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