INT12367

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Context Info
Confidence 0.03
First Reported 1982
Last Reported 2005
Negated 2
Speculated 0
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 2.05
Pain Relevance 9.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PRLR) plasma membrane (PRLR)
Anatomy Link Frequency
brain 3
MVD 2
GPI 1
forebrain 1
CNS 1
PRLR (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 30 100.00 Very High Very High Very High
opiate 5 100.00 Very High Very High Very High
Morphine 8 99.30 Very High Very High Very High
Enkephalin 26 99.22 Very High Very High Very High
Opioid 25 98.90 Very High Very High Very High
agonist 14 98.74 Very High Very High Very High
Central nervous system 9 98.46 Very High Very High Very High
midbrain 5 97.80 Very High Very High Very High
dopamine receptor 1 97.80 Very High Very High Very High
antagonist 16 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Tics 20 99.28 Very High Very High Very High
Hypoxia 1 95.96 Very High Very High Very High
Depression 2 92.24 High High
Stress 2 87.20 High High
Adenoma 2 80.88 Quite High
Respiratory Failure 2 75.00 Quite High
Syndrome 6 33.04 Quite Low
Immunization 8 5.00 Very Low Very Low Very Low
Growth Hormone Deficiency 2 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(ii) N,N-Me2-Dmt-Tic-OH (12) was equally efficacious in delta receptor binding (Ki delta = 0.12 nM; Ki mu/Ki delta = 20000), but delta antagonism rose considerably (pA2 = 9.4; Ke = 0.28 nM) with weak mu antagonism (pA2 = 5.8; Ke = 1.58 microM; GPI/MVD = 1:5640).
delta receptor Binding (binding) of in MVD associated with tics
1) Confidence 0.03 Published 1997 Journal J. Med. Chem. Section Abstract Doc Link 9301674 Disease Relevance 0.66 Pain Relevance 0.48
beta-FNA, the beta-fumaramate methyl ester of naltrexone, has been shown to antagonize irreversibly the actions of morphine on the guinea pig ileum and mouse vas deferens bioassays but does not affect the actions of delta-receptor ligands on the mouse vas deferens bioassay, suggesting that the compound does not irreversibly bind to the delta receptor.
delta receptor Neg (not) Binding (bind) of in vas deferens associated with morphine
2) Confidence 0.01 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6088697 Disease Relevance 0 Pain Relevance 0.40
which may be the reason why our assay did not cross-react with
hPRL. 
hPRL Neg (not) Binding (cross) of
3) Confidence 0.01 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0.17 Pain Relevance 0.06
which may be the reason why our assay did not cross-react with
hPRL. 
hPRL Binding (react) of
4) Confidence 0.01 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0.17 Pain Relevance 0.06
(ii) N,N-Me2-Dmt-Tic-OH (12) was equally efficacious in delta receptor binding (Ki delta = 0.12 nM; Ki mu/Ki delta = 20000), but delta antagonism rose considerably (pA2 = 9.4; Ke = 0.28 nM) with weak mu antagonism (pA2 = 5.8; Ke = 1.58 microM; GPI/MVD = 1:5640).
delta receptor Binding (binding) of in GPI associated with tics
5) Confidence 0.01 Published 1997 Journal J. Med. Chem. Section Abstract Doc Link 9301674 Disease Relevance 0.66 Pain Relevance 0.48
The kappa and delta receptor binding is heterogeneously distributed in regions occupied by midbrain dopaminergic neurons, and several fold lower than the binding of mu opioid receptors in the same brain regions.
delta receptor Binding (binding) of in brain associated with mu opioid receptor and midbrain
6) Confidence 0.01 Published 1993 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 8383985 Disease Relevance 0 Pain Relevance 0.61
Differences in binding kinetics, ions and nucleotides interactions with rat brain opiate mu and delta receptor subtypes were investigated using respectively DAGO (Tyr-D-Ala-Gly-MePhe-Gly-ol) and DTLET (Tyr-D-Thr-Gly-Phe-Leu-Thr) as highly selective mu and delta ligands.
delta receptor Binding (interactions) of in brain associated with opiate
7) Confidence 0.01 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319853 Disease Relevance 0 Pain Relevance 0.26
A high level of correspondence was observed between the distribution of delta receptor mRNA and delta receptor binding as defined by the selective ligand [3H]D-Pen2-Pen5-enkephalin.
delta receptor Binding (binding) of associated with enkephalin
8) Confidence 0.01 Published 1993 Journal J. Chem. Neuroanat. Section Abstract Doc Link 8142072 Disease Relevance 0 Pain Relevance 0.49
Delta opioid receptor mRNA distribution in the brain: comparison to delta receptor binding and proenkephalin mRNA.
delta receptor Binding (binding) of in brain associated with enkephalin and opioid receptor
9) Confidence 0.01 Published 1993 Journal J. Chem. Neuroanat. Section Title Doc Link 8142072 Disease Relevance 0 Pain Relevance 0.60
The present study describes the cellular localization in the central nervous system (CNS) of an mRNA encoding this receptor and compares it with the distribution of delta receptor binding and proenkephalin mRNA using a combination of in situ hybridization and receptor autoradiographic techniques.
delta receptor Binding (binding) of in CNS associated with central nervous system
10) Confidence 0.01 Published 1993 Journal J. Chem. Neuroanat. Section Abstract Doc Link 8142072 Disease Relevance 0 Pain Relevance 0.31
The agonists DADL, morphine, and DAMGO competitively inhibited bremazocine binding to the tagged delta receptor with K(I)'s of 0.9, 370, and 620 nM, respectively.
delta receptor Binding (binding) of associated with agonist and morphine
11) Confidence 0.01 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893587 Disease Relevance 0 Pain Relevance 0.27
For regulation of paO2, a mu-delta-receptor interaction is postulated while paCO2 and sensory blockade are affected solely by the opioid mu-site.
mu-delta-receptor Binding (interaction) of associated with opioid
12) Confidence 0.00 Published 2002 Journal Arzneimittelforschung Section Abstract Doc Link 12572526 Disease Relevance 0.40 Pain Relevance 0.50
Metkephamid is differentiated from morphine by its better than 12-fold higher affinity for the delta receptor.
delta receptor Binding (affinity) of associated with morphine
13) Confidence 0.00 Published 1982 Journal Peptides Section Abstract Doc Link 6294639 Disease Relevance 0 Pain Relevance 0.88
Administration of SKF 82958 had no affect on delta receptor binding, forskolin-stimulated adenylyl cyclase activity, or G protein/adenylyl cyclase coupling.
delta receptor Binding (binding) of
14) Confidence 0.00 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10698003 Disease Relevance 0 Pain Relevance 0.87
The reduction in delta receptor binding after DSLET treatment was not accompanied by significantly diminished levels of delta receptor mRNA.
delta receptor Binding (binding) of
15) Confidence 0.00 Published 1996 Journal Neuroreport Section Abstract Doc Link 8856708 Disease Relevance 0 Pain Relevance 0.99
Delta 9-THC also inhibited the binding of the delta opioid [3H]D-Pen2, D-Pen5-enkephalin and the opioid antagonist [3H]naloxone (Ki = 16 and 19 microM, respectively) but failed to inhibit the binding of the kappa opioid [3H]ethylketocyclazocine (after suppression of mu and delta receptor binding), the phencyclidine analog [3H]N-(1-[2-theinyl]cyclohexyl)piperidine, the dopamine antagonist [3H]spiroperidol or the muscarinic antagonist [3H]quinuclidinyl benzilate.
delta receptor Binding (binding) of associated with dopamine, antagonist, narcan, enkephalin and opioid
16) Confidence 0.00 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3033219 Disease Relevance 0 Pain Relevance 1.07
Autoradiographic study of irreversible binding of [3H]beta-funaltrexamine to opioid receptors in the rat forebrain: comparison with mu and delta receptor distribution.
delta receptor Binding (binding) of in forebrain associated with enkephalin and opioid receptor
17) Confidence 0.00 Published 1991 Journal Brain Res. Section Title Doc Link 1645609 Disease Relevance 0 Pain Relevance 0.53
Substitution of Aib in the 2-position led to a compound, H-Tyr-Aib-Phe-Asp-Val-Val-Gly-NH2, which displayed lower delta receptor affinity than the parent peptide but higher delta selectivity and, surprisingly, three times higher antinociceptive potency.
delta receptor Binding (affinity) of associated with antinociceptive and potency
18) Confidence 0.00 Published 1997 Journal Peptides Section Abstract Doc Link 9437724 Disease Relevance 0 Pain Relevance 0.82

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