INT123672

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 0.77
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F2R) Golgi apparatus (F2R) plasma membrane (F2R)
signal transducer activity (F2R)
Anatomy Link Frequency
uterine smooth muscle 2
cardiomyocyte 1
platelets 1
F2R (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 2 96.36 Very High Very High Very High
action potential duration 3 94.76 High High
ischemia 1 92.52 High High
Angina 1 89.24 High High
Inflammation 26 78.08 Quite High
antagonist 1 62.88 Quite High
agonist 2 61.92 Quite High
aspirin 6 58.80 Quite High
Pain 116 50.00 Quite Low
Action potential 1 47.68 Quite Low
Disease Link Frequency Relevance Heat
Injury 4 93.84 High High
Coronary Artery Disease 1 92.84 High High
Cv General 3 Under Development 1 89.24 High High
Acute Coronary Syndrome 3 88.04 High High
Suicidal Behaviour 1 81.88 Quite High
Atherosclerotic Plaque 1 81.64 Quite High
INFLAMMATION 26 78.08 Quite High
Pain 108 50.00 Quite Low
Necrosis 12 37.04 Quite Low
Cancer 12 36.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it can be concluded that thrombin-induced uterine smooth muscle cell collagen contractility is mediated by F2R activation and may in part be ROCK-1 dependent.
Positive_regulation (mediated) of thrombin-induced in uterine smooth muscle
1) Confidence 0.47 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
Hirudin (10 U/ml) blocked the thrombin-induced increase, with a return to basal levels of contractility at all time-points analysed (Figure 4A and 4B).
Positive_regulation (increase) of thrombin-induced
2) Confidence 0.47 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
F2R mRNA was up-regulated upon thrombin stimulation of collagen contractility.
Positive_regulation (-) of F2R
3) Confidence 0.44 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
Thrombin-induced collagen contractility resulted in F2R activation which may in part be mediated by the ROCK-1 pathway.
Positive_regulation (activation) of F2R
4) Confidence 0.44 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
F2R mRNA was up-regulated upon thrombin stimulation of collagen contractility.
Positive_regulation (up) of F2R
5) Confidence 0.44 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
Therefore, it can be concluded that thrombin-induced uterine smooth muscle cell collagen contractility is mediated by F2R activation and may in part be ROCK-1 dependent.
Positive_regulation (activation) of F2R in uterine smooth muscle
6) Confidence 0.44 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
Thrombin, through PAR1 activation, increases persistent component of the Na(+) current resulting in an uncontrolled sodium influx into the cardiomyocyte, which can contribute to cellular injuries observed during cardiac ischemia.
Positive_regulation (activation) of PAR1 in cardiomyocyte associated with coronary artery disease, ischemia and injury
7) Confidence 0.40 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18326052 Disease Relevance 0.27 Pain Relevance 0.39
Treatment of platelets with thrombin (activates PAR1 and PAR4 thrombin receptors), SFLLRN (PAR1), AYPGKF (PAR4), collagen (alpha2beta1 and GPVI/FCgammaIIR receptors) and U46619 (TXA(2)) resulted in strong activation of p38 MAPK.
Positive_regulation (activates) of thrombin in platelets
8) Confidence 0.08 Published 2004 Journal Thromb. Haemost. Section Abstract Doc Link 15583748 Disease Relevance 0.50 Pain Relevance 0.19
The estimation of tR from the values of T0, AT and ?
Positive_regulation (estimation) of tR
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859063 Disease Relevance 0 Pain Relevance 0

General Comments

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