INT123681

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Context Info
Confidence 0.25
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN)
aging (JUN) nucleus (JUN) DNA binding (JUN)
Anatomy Link Frequency
Plaques 2
JUN (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 6 98.12 Very High Very High Very High
Angina 1 84.00 Quite High
metalloproteinase 5 75.92 Quite High
sSRI 2 73.04 Quite High
fluoxetine 1 72.76 Quite High
tricyclic antidepressant 1 50.12 Quite High
Serotonin 1 47.60 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 7 99.20 Very High Very High Very High
Cv General 3 Under Development 1 84.00 Quite High
Glioma 3 82.40 Quite High
Atherosclerotic Plaque 4 81.60 Quite High
Neuroblastoma 2 75.00 Quite High
Rupture 1 52.96 Quite High
Syndrome 1 52.08 Quite High
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of p-c-Jun and subsequent increased Cyt c mitochondrial release participate in the apoptotic mechanism of the antidepressant.
Positive_regulation (increased) of Localization (release) of p-c-Jun associated with antidepressant and apoptosis
1) Confidence 0.25 Published 2005 Journal J. Mol. Neurosci. Section Abstract Doc Link 16055945 Disease Relevance 0.90 Pain Relevance 0.34
Plaques from unstable patients had an increased infiltration of macrophages and T-lymphocytes, nuclear localisation of AP-1 and the NF-kappaB subunit p65, as well as increased positive immunostaining for MMP9 and tPA.
Positive_regulation (increased) of Localization (localisation) of AP-1 in Plaques
2) Confidence 0.01 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15583828 Disease Relevance 0.40 Pain Relevance 0.25

General Comments

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