INT123682

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.15
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN)
aging (JUN) nucleus (JUN) DNA binding (JUN)
Anatomy Link Frequency
MDMs 1
Plaques 1
nucleus 1
eosinophils 1
JUN (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 25 99.98 Very High Very High Very High
dexamethasone 20 99.30 Very High Very High Very High
Inflammation 53 98.84 Very High Very High Very High
qutenza 9 98.16 Very High Very High Very High
antidepressant 6 98.12 Very High Very High Very High
Osteoarthritis 65 89.36 High High
Angina 2 81.40 Quite High
metalloproteinase 8 75.00 Quite High
Inflammatory stimuli 3 74.32 Quite High
sSRI 2 73.04 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 11 99.20 Very High Very High Very High
INFLAMMATION 63 98.84 Very High Very High Very High
Cancer 9 98.64 Very High Very High Very High
Death 3 98.00 Very High Very High Very High
Asthma 6 91.24 High High
Osteoarthritis 66 89.36 High High
Glioma 3 82.40 Quite High
Cv General 3 Under Development 2 81.40 Quite High
Increased Venous Pressure Under Development 6 81.04 Quite High
Atherosclerotic Plaque 4 79.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The shift of redox balance towards oxidative conditions facilitates phosphorylation and activation of c-Jun N-terminal kinase (JNK), a kinase that promotes Jun translocation into the nucleus.
Localization (translocation) of Jun in nucleus
1) Confidence 0.50 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.51 Pain Relevance 0.15
B response elements and the use of small interfering RNA technology, will contribute to our understanding of the importance of AP-1 and NF-?
Localization (importance) of AP-1
2) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.35 Pain Relevance 0.20
Activation of p-c-Jun and subsequent increased Cyt c mitochondrial release participate in the apoptotic mechanism of the antidepressant.
Localization (release) of p-c-Jun associated with antidepressant and apoptosis
3) Confidence 0.38 Published 2005 Journal J. Mol. Neurosci. Section Abstract Doc Link 16055945 Disease Relevance 0.90 Pain Relevance 0.34
Thrombin induced translocation of c-fos and c-jun to the nucleus of MDMs.
Localization (translocation) of c-jun in MDMs
4) Confidence 0.35 Published 2009 Journal Blood Section Abstract Doc Link 19652200 Disease Relevance 0.89 Pain Relevance 0.28
Dexamethasone, as other GCS, inhibits cytokines release by eosinophils by interference with transcription factors such as NF-kB and AP-1 [9].
Localization (release) of AP-1 in eosinophils associated with dexamethasone and cytokine
5) Confidence 0.16 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1131914 Disease Relevance 0.47 Pain Relevance 0.44
Glucocorticoids, acting through the glucocorticoid receptor (GR), are able to selectively repress inflammatory gene expression by utilizing several distinct mechanisms targeting nuclear factor-varphiB and activator protein-1 activation complexes and by effects on mitogen-activated protein kinases.
Localization (targeting) of activator protein-1 associated with inflammation
6) Confidence 0.02 Published 2008 Journal Curr Allergy Asthma Rep Section Abstract Doc Link 18417060 Disease Relevance 0.45 Pain Relevance 0.20
Plaques from unstable patients had an increased infiltration of macrophages and T-lymphocytes, nuclear localisation of AP-1 and the NF-kappaB subunit p65, as well as increased positive immunostaining for MMP9 and tPA.
Localization (localisation) of AP-1 in Plaques
7) Confidence 0.02 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15583828 Disease Relevance 0.34 Pain Relevance 0.24
It blocks the translocation of nuclear factor kappa B (NF-kB), activator protein 1 (AP-1), and signal transducer and activator of transcription (STAT3) signaling pathway that are required for carcinogenesis.
Localization (translocation) of AP-1
8) Confidence 0.02 Published 2010 Journal Indian J Cancer Section Abstract Doc Link 20071791 Disease Relevance 0.24 Pain Relevance 0.52

General Comments

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