INT12370

Context Info Confidence 0.67 First Reported 1984 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 7 Disease Relevance 1.70 Pain Relevance 1.37

cytoskeleton (TNS1) cytoplasm (TNS1)

Anatomy Link Frequency thyroid 1 central nervous system 1 TNS1 (Homo sapiens)

Pain Link Frequency Relevance Heat transcutaneous nerve stimulation 11 100.00 Central nervous system 2 99.68 lidocaine 5 96.72 depression 1 79.52 Peripheral nerve stimulation 1 71.96 anesthesia 6 50.00 Codeine 2 10.00 Pain 1 10.00 Pain score 1 5.00

Disease Link Frequency Relevance Heat Neurologic Manifestations 12 99.82 Increased Venous Pressure Under Development 2 92.84 Thyroid Nodule 32 91.60 Hypertension 2 91.20 Cancer 42 85.28 Central Nervous System Disease 1 83.28 Malignant Neoplastic Disease 32 83.08 Neoplastic Processes 2 81.44 Depression 1 79.52 Hyperthyroidism 12 20.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

During the first 3 days after surgery, the presence of TNS, its intensity and duration, and patient functional level were recorded.

Gene_expression (presence) of TNS

1) Confidence 0.67 Published 2003 Journal Anesthesiology Section Body Doc Link 12552209 Disease Relevance 0.17 Pain Relevance 0

The present study was performed to investigate whether TNS is present more frequently in patients undergoing surgery in the supine position with use of hyperbaric lidocaine compared with hyperbaric bupivacaine.

Gene_expression (present) of TNS associated with lidocaine and neurologic manifestations

2) Confidence 0.60 Published 2000 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 10714841 Disease Relevance 0.44 Pain Relevance 0.26

In a short-term experiment TNS produced a significant lowering of systolic, mean arterial, and diastolic pressures amounting to 8 mmHg (P less than 0.01), 6 mmHg (P less than 0.01), and 4 mmHg (P less than 0.02), respectively.

Gene_expression (produced) of TNS associated with transcutaneous nerve stimulation

3) Confidence 0.53 Published 1991 Journal Clin Physiol Section Abstract Doc Link 1645634 Disease Relevance 0.32 Pain Relevance 0.59

CONCLUSIONS: Procaine may be a useful alternative to lidocaine for short procedures, and it is less likely to produce TNS.

Gene_expression (produce) of TNS

4) Confidence 0.52 Published 1998 Journal J Clin Anesth Section Body Doc Link 9702622 Disease Relevance 0 Pain Relevance 0

A possible source of this increased plasma VIP following TNS is the central nervous system.

Gene_expression (source) of TNS in central nervous system associated with central nervous system and transcutaneous nerve stimulation

5) Confidence 0.49 Published 1984 Journal Gen. Pharmacol. Section Abstract Doc Link 6335447 Disease Relevance 0.18 Pain Relevance 0.52

The cytodiagnosis of TNs by FNA is complex for the following reasons [26]:

Gene_expression (cytodiagnosis) of TNs

6) Confidence 0.45 Published 2005 Journal Cytojournal Section Body Doc Link PMC1184092 Disease Relevance 0.41 Pain Relevance 0

Fine needle aspiration (FNA) of the thyroid now is practiced worldwide and proves to be the most economical and reliable diagnostic procedure to identify TNs that need surgical excision and TNs that can be managed conservatively.

Gene_expression (excision) of TNs in thyroid

7) Confidence 0.45 Published 2005 Journal Cytojournal Section Abstract Doc Link PMC1184092 Disease Relevance 0.18 Pain Relevance 0

General Comments

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