INT123701

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 61
Total Number 76
Disease Relevance 48.94
Pain Relevance 9.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (VDR) signal transduction (VDR) cell morphogenesis (VDR)
nucleus (VDR) DNA binding (VDR)
Anatomy Link Frequency
muscle 2
hip 2
macrophages 1
liver 1
colon 1
VDR (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 461 99.80 Very High Very High Very High
fibrosis 348 99.70 Very High Very High Very High
carbamazepine 168 99.60 Very High Very High Very High
backache 84 98.32 Very High Very High Very High
Central nervous system 96 97.76 Very High Very High Very High
rheumatoid arthritis 64 97.52 Very High Very High Very High
Lasting pain 186 96.88 Very High Very High Very High
Multiple sclerosis 287 96.64 Very High Very High Very High
tolerance 23 96.56 Very High Very High Very High
Chronic low back pain 2 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 185 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 30 100.00 Very High Very High Very High
Syndrome 57 99.98 Very High Very High Very High
Poisoning 87 99.96 Very High Very High Very High
Bone Fracture 40 99.96 Very High Very High Very High
Hypercalcemia 266 99.92 Very High Very High Very High
Dermatomyositis 21 99.88 Very High Very High Very High
Targeted Disruption 35 99.84 Very High Very High Very High
Pain 631 99.80 Very High Very High Very High
Osteoporosis 572 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vitamin D deficiency not only causes rickets among children but also precipitates and exacerbates osteoporosis among adults and causes the painful bone disease osteomalacia.
Negative_regulation (deficiency) of Vitamin D associated with pain, rickets, osteoporosis and bone cancer
1) Confidence 0.59 Published 2004 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 15585788 Disease Relevance 1.17 Pain Relevance 0.17
The functional characterization of the patient's VDR reflected the localization of the mutation (18 different ones described to date), thus providing vital information about the structure-function relationship in the human VDR and the essentiality of the VDR as the mediator of vitamin D action.
Negative_regulation (information) of VDR
2) Confidence 0.43 Published 2007 Journal J. Bone Miner. Res. Section Abstract Doc Link 18290711 Disease Relevance 0.56 Pain Relevance 0.07
Vitamin D deficiency is an unrecognized epidemic among both children and adults in the United States.
Negative_regulation (deficiency) of Vitamin D
3) Confidence 0.43 Published 2004 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 15585788 Disease Relevance 1.09 Pain Relevance 0.15
Vitamin D deficiency in this population was without florid signs (63% showed no tenderness).
Negative_regulation (deficiency) of Vitamin D
4) Confidence 0.41 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 1.44 Pain Relevance 0.49
The common etiological factors of vitamin D deficiency are lack of exposure to sun rays (solar ultraviolet-B exposure to as much of body surface as possible produces vitamin D) and decreased intake of foods rich in vitamin D.
Negative_regulation (deficiency) of vitamin D in body
5) Confidence 0.41 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 0.70 Pain Relevance 0.03
This small retrospective study shows that vitamin D deficiency is not uncommon but frank osteomalacia is uncommon.
Negative_regulation (deficiency) of vitamin D associated with rickets
6) Confidence 0.41 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 0.46 Pain Relevance 0
Vitamin D deficiency was suspected.
Negative_regulation (deficiency) of Vitamin D
7) Confidence 0.41 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 1.13 Pain Relevance 0.30
This

article provides a retrospective, examining the effects of Vitamin D deficiency in 71

Spec (examining) Negative_regulation (deficiency) of Vitamin D
8) Confidence 0.41 Published 2010 Journal International Journal of Endocrinology Section Abstract Doc Link PMC2778352 Disease Relevance 0.16 Pain Relevance 0
symptoms, or between the severity of Vitamin D deficiency and the number of symptoms
Negative_regulation (deficiency) of Vitamin D
9) Confidence 0.41 Published 2010 Journal International Journal of Endocrinology Section Abstract Doc Link PMC2778352 Disease Relevance 0.16 Pain Relevance 0
Vitamin D deficiency is not uncommon even in the sunny land of India.
Negative_regulation (deficiency) of Vitamin D
10) Confidence 0.41 Published 2010 Journal International Journal of Endocrinology Section Abstract Doc Link PMC2778352 Disease Relevance 0.15 Pain Relevance 0
Vitamin D deficiency in this population, while symptomatic, was without any of florid signs (63% showed no tenderness—as shown in Table 3).
Negative_regulation (deficiency) of Vitamin D
11) Confidence 0.41 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 0.48 Pain Relevance 0.13
Reports of severe adult-onset vitamin D deficiency, known as osteomalacic myopathy, provided the first evidence of a link between vitamin D and SkM in humans.
Negative_regulation (deficiency) of vitamin D in SkM associated with muscle disease
12) Confidence 0.38 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3010688 Disease Relevance 0.56 Pain Relevance 0.14
Ninety-three percent of ambulatory outpatients with chronic, nonspecific musculoskeletal pain were found to be deficient in vitamin D [13].
Negative_regulation (deficient) of vitamin D associated with pain
13) Confidence 0.37 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3010688 Disease Relevance 0.81 Pain Relevance 0.55
exposure and inadequate oral intake are both responsible for vitamin D deficiency.
Negative_regulation (deficiency) of vitamin D
14) Confidence 0.36 Published 2010 Journal International Journal of Endocrinology Section Abstract Doc Link PMC2778352 Disease Relevance 0.16 Pain Relevance 0
It is difficult to guess the prevalence of vitamin D deficiency in the community, but it does seem logical to assume that osteomalacia (as well as rickets) are only the tip of the iceberg.
Negative_regulation (deficiency) of vitamin D associated with rickets
15) Confidence 0.36 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 0.78 Pain Relevance 0.03
Additionally, the symptoms these patients report, symptoms that indicate a lack of vitamin D, may also be caused by other incidental factors.
Negative_regulation (lack) of vitamin D
16) Confidence 0.36 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 1.02 Pain Relevance 0.34
To our surprise the prevalence of vitamin D deficiency was high.
Negative_regulation (deficiency) of vitamin D
17) Confidence 0.36 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 0.21 Pain Relevance 0
This is because, compared with the commonness of vitamin D deficiency, clinical osteomalacia is not a common disorder.
Negative_regulation (deficiency) of vitamin D associated with rickets
18) Confidence 0.36 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 0.78 Pain Relevance 0.03
Thus paradoxically, vitamin D deficiency may be a disease of the rich!
Negative_regulation (deficiency) of vitamin D associated with disease
19) Confidence 0.36 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 1.05 Pain Relevance 0.13
A proforma was prepared to record relevant details (Appendix A-proforma: profile of vitamin D deficiency).
Negative_regulation (deficiency) of vitamin D in Appendix
20) Confidence 0.36 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 0.53 Pain Relevance 0.04

General Comments

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