INT123705

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2011
Negated 8
Speculated 1
Reported most in Body
Documents 40
Total Number 42
Disease Relevance 19.47
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SMARCB1) nucleoplasm (SMARCB1) nuclear chromosome (SMARCB1)
nucleolus (SMARCB1) nucleus (SMARCB1) cell cycle (SMARCB1)
Anatomy Link Frequency
neuronal 3
blood 1
brain 1
face 1
SNR 1
SMARCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 40 100.00 Very High Very High Very High
sNRI 9 100.00 Very High Very High Very High
Paracetamol 21 98.96 Very High Very High Very High
sSRI 18 96.28 Very High Very High Very High
tricyclic antidepressant 8 96.10 Very High Very High Very High
withdrawal 65 94.32 High High
pain pelvic 3 91.40 High High
Spinal cord 6 89.56 High High
Pain 29 87.12 High High
Endep 3 85.88 High High
Disease Link Frequency Relevance Heat
Malaria 925 99.94 Very High Very High Very High
Fever 313 99.84 Very High Very High Very High
Malignant Neoplastic Disease 7 99.68 Very High Very High Very High
Monosomy 2 99.68 Very High Very High Very High
Visceral Leishmaniasis 282 99.44 Very High Very High Very High
Vomiting 19 99.32 Very High Very High Very High
Middle Cerebral Artery Infarction 250 99.20 Very High Very High Very High
Stroke 545 99.08 Very High Very High Very High
Cancer 131 98.26 Very High Very High Very High
Cv Unclassified Under Development 90 97.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using Western blotting and immunohistochemistry, PAK1, INI1 and MMP11 protein expression and localization was determined in the contralateral and ipsilateral brain areas of individual stroke patients and rats subjected to MCAO, and in HBMEC and HFN exposed to OGD and reperfusion.


Gene_expression (expression) of INI1 in brain associated with middle cerebral artery infarction and stroke
1) Confidence 0.73 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.45 Pain Relevance 0
Analysis of INI1 protein expression in samples from individual stroke patients showed that protein levels were increased in peri-infarcted and infarcted regions in 8 of 12 samples (Table 4; Figure 2Bi and 2Bii).
Gene_expression (expression) of INI1 associated with stroke
2) Confidence 0.73 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.51 Pain Relevance 0
Weak cytoplasmic staining was observed in contralateral neurons but no differences in the level of INI1 neuronal expression occurred following MCAO (data not included).
Gene_expression (expression) of INI1 in neuronal associated with middle cerebral artery infarction
3) Confidence 0.73 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.60 Pain Relevance 0.04
Molecular genetic studies revealed monosomy 22 and loss of expression of the INI1 gene in 22q11.2.
Gene_expression (expression) of INI1 gene associated with monosomy
4) Confidence 0.71 Published 2007 Journal J. Neurooncol. Section Abstract Doc Link 17377740 Disease Relevance 0.97 Pain Relevance 0.17
Subsequently, immunohistochemical studies revealed the absence of INI1 gene expression in the malignant cells, supporting the diagnosis of AT/RT.
Gene_expression (expression) of INI1 gene associated with malignant neoplastic disease
5) Confidence 0.71 Published 2007 Journal J. Neurooncol. Section Abstract Doc Link 17377740 Disease Relevance 0.97 Pain Relevance 0.17
This suggested that venlafaxine might be a cost-effective first-line drug compared with the SSRIs and TCAs.59 In 2005, a cost-effectiveness review enrolled several studies performed in nine countries comparing SNRIs vs TCAs vs SSRIs and concluded that the higher initial cost of SNRI is probably compensated by higher success rates of drugs of this class.58 In 2007, a budget-impact analysis to evaluate the impact of SNRI introduction in the Brazilian national drug-free formulary used an existing decision-tree analysis and concluded that, from a public healthcare perspective, there are no significant difference in cost-effectiveness between the drug classes of SNRIs, SSRIs, and TCAs.56 The same authors performed another budget-impact analysis to evaluate the cost-effectiveness of amitriptyline, fluoxetine and venlafaxine in Colombia and found that amitriptyline was more cost-effective compared to the other two drugs (venlafaxine costs were evaluated for the brand-name product, as generics were not currently available in that country).57


Gene_expression (introduction) of SNRI associated with endep, snri, tricyclic antidepressant, ssri and fluoxetine
6) Confidence 0.65 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2781064 Disease Relevance 0.17 Pain Relevance 0.86
Cells from contralateral white matter were not stained for INI1 but some weak neuronal cytoplasmic staining was seen in grey matter (Figure 2Ci).
Neg (not) Gene_expression (stained) of INI1 in neuronal
7) Confidence 0.63 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.61 Pain Relevance 0
Filters were blocked in 1% w/v bovine serum albumin (BSA) in Tris-buffered saline Tween (TBS Tween) and stained overnight at 4°C with antibodies to the following proteins (obtained from Autogen Bioclear, Wiltshire, UK, unless stated otherwise) diluted in 1% BSA: MMP11 (CalBiochem; 1:500), PAK1 (1:500), INI1 (1:500), and ?
Neg (blocked) Gene_expression (blocked) of INI1
8) Confidence 0.63 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0 Pain Relevance 0.04
PAK1 was only induced in the human study although present in both microarray sets, MMP11 was induced in both cases, while INI1 was induced in the human but was not present in the rat microarray set.
Neg (not) Gene_expression (present) of INI1
9) Confidence 0.63 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.40 Pain Relevance 0
Filters were blocked in 1% w/v bovine serum albumin (BSA) in Tris-buffered saline Tween (TBS Tween) and stained overnight at 4°C with antibodies to the following proteins (obtained from Autogen Bioclear, Wiltshire, UK, unless stated otherwise) diluted in 1% BSA: MMP11 (CalBiochem; 1:500), PAK1 (1:500), INI1 (1:500), and ?
Gene_expression (1:500) of INI1
10) Confidence 0.63 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0 Pain Relevance 0.03
In the rat, RT-PCR and Western blotting demonstrated no notable changes in INI1 mRNA and protein expression respectively following MCAO.
Gene_expression (expression) of INI1 associated with middle cerebral artery infarction
11) Confidence 0.63 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.67 Pain Relevance 0.04
SNR are also found in humans although, in contrast to laboratory species, CR are more commonly noted.
Gene_expression (found) of SNR in SNR
12) Confidence 0.60 Published 2004 Journal J Toxicol Environ Health B Crit Rev Section Abstract Doc Link 15586878 Disease Relevance 0.30 Pain Relevance 0.07
All febrile children were treated, regardless of RDT result, given the investigational nature of this study, for maximal safety of participants and consistent with local practices.
Gene_expression (result) of RDT associated with fever
13) Confidence 0.57 Published 2009 Journal Malar J Section Body Doc Link PMC2804690 Disease Relevance 0.65 Pain Relevance 0
The cost of false-negative diagnosis was neglected, given that only 1.1% of the cohort tested negative using RDT.
Neg (negative) Gene_expression (using) of RDT
14) Confidence 0.57 Published 2009 Journal Malar J Section Body Doc Link PMC2804690 Disease Relevance 0.54 Pain Relevance 0
To test whether our microarray analysis could predict novel candidate genes involved in the cerebral response to ischaemia with possible functional importance and significance in stroke-induced neuronal damage, we measured protein expression and cellular localisation for three induced genes, INI1, PAK1 and MMP11.
Gene_expression (expression) of INI1 in neuronal associated with stroke and cv unclassified under development
15) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.69 Pain Relevance 0.04
The expression of novel genes, including p21-activated kinase 1 (PAK1), matrix metalloproteinase 11 (MMP11) and integrase interactor 1, was further analyzed by RT-PCR, Western blotting and immunohistochemistry.
Spec (analyzed) Gene_expression (expression) of integrase interactor 1 associated with metalloproteinase
16) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC2194693 Disease Relevance 0.22 Pain Relevance 0.05
Children with positive RDT results and high respiratory rate (?
Gene_expression (results) of RDT in respiratory
17) Confidence 0.56 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2943441 Disease Relevance 0.69 Pain Relevance 0.24
The proportion of children with a positive RDT in this subgroup was 28.5%; hence there was no difference in the RDT positivity rate whether the child had reported fever or had a measured temperature of ?
Gene_expression (proportion) of RDT associated with fever
18) Confidence 0.56 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2943441 Disease Relevance 1.05 Pain Relevance 0
"Correct" prescription of antimalarials is defined as those with positive RDT who were prescribed antimalarial and those with negative RDT who were not prescribed antimalarials.
Gene_expression (prescribed) of RDT
19) Confidence 0.56 Published 2008 Journal Malar J Section Body Doc Link PMC2613413 Disease Relevance 0.09 Pain Relevance 0
RDT training
Gene_expression (training) of RDT
20) Confidence 0.56 Published 2008 Journal Malar J Section Body Doc Link PMC2613413 Disease Relevance 0.30 Pain Relevance 0

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