INT123713

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Context Info
Confidence 0.31
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.96
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm5) plasma membrane (Grm5) cytoplasm (Grm5)
signal transducer activity (Grm5)
Anatomy Link Frequency
neuronal 1
Grm5 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 9 100.00 Very High Very High Very High
Neuronal excitability 1 100.00 Very High Very High Very High
Eae 18 98.96 Very High Very High Very High
depression 3 97.76 Very High Very High Very High
Lasting pain 3 97.20 Very High Very High Very High
Analgesic 2 95.00 High High
Thermal hyperalgesia 3 92.44 High High
antagonist 19 91.12 High High
Neuropathic pain 1 89.24 High High
Central nervous system 3 88.80 High High
Disease Link Frequency Relevance Heat
Nociception 4 99.08 Very High Very High Very High
Anxiety Disorder 22 98.12 Very High Very High Very High
Depression 3 97.76 Very High Very High Very High
Pain 7 97.20 Very High Very High Very High
Hyperalgesia 4 92.44 High High
Targeted Disruption 38 90.88 High High
Neuropathic Pain 4 89.24 High High
Hypersensitivity 4 78.80 Quite High
Intellectual Impairment 1 78.76 Quite High
Body Weight 2 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MGluR5 binding and functional data were obtained that identified (1) several novel alkynes with comparable affinities to 1 at mGluR5 (e.g., 10 and 20-23), but (2) most structural variations to the amide template were not well tolerated, although a few potent amides were discovered (e.g., 55 and 56).
MGluR5 Binding (binding) of
1) Confidence 0.31 Published 2009 Journal J. Med. Chem. Section Abstract Doc Link 19445453 Disease Relevance 0.31 Pain Relevance 0.36
We also found no difference in rectal temperature between genotypes (Table 1), suggesting that there are no gross metabolic disturbances induced by disruption of grm5.
grm5 Neg (no) Binding (disruption) of
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.46 Pain Relevance 0.03
The metabotropic glutamate receptor subtype 5 (mGlu5) and glutamatergic neurotransmission are associated with the pathophysiology of disorders such as anxiety, depression or chronic pain.
mGlu5 Binding (associated) of associated with depression, lasting pain, glutamate receptor and anxiety disorder
3) Confidence 0.12 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17967450 Disease Relevance 0.29 Pain Relevance 0.23
The metabotropic glutamate receptor subtype 5 (mGlu5) and glutamatergic neurotransmission are associated with the pathophysiology of disorders such as anxiety, depression or chronic pain.
metabotropic glutamate receptor subtype 5 Binding (associated) of associated with depression, lasting pain, glutamate receptor and anxiety disorder
4) Confidence 0.11 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17967450 Disease Relevance 0.29 Pain Relevance 0.23
AQP4 residues 23-32 also contain the site required for the interaction with the regulator glutamate receptor 5 (mGluR5) and the catalytic subunit of Na,K-ATPase in forming macromolecular microdomains that may participate in K+ homeostasis [22].
regulator glutamate receptor 5 Binding (interaction) of associated with glutamate receptor
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0 Pain Relevance 0.05
These results suggest a role for mGlu5 receptors in multiple nociceptive modalities, though CNS side effects may be a limiting factor in developing mGlu5 receptor analgesic compounds.
mGlu5 Binding (role) of associated with nociception and analgesic
6) Confidence 0.02 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15588730 Disease Relevance 1.36 Pain Relevance 1.05
The Group I mGlu receptor, mGlu5, is well positioned to regulate and fine-tune neuronal excitability and synaptic transmission through its modulation of various signal transduction pathways and interactions with other transmitter systems.
mGlu5 Binding (interactions) of in neuronal associated with neuronal excitability
7) Confidence 0.00 Published 2005 Journal Curr Top Med Chem Section Abstract Doc Link 16178734 Disease Relevance 0.24 Pain Relevance 0.43

General Comments

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