INT12372

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Context Info
Confidence 0.53
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 1.85
Pain Relevance 11.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
neuron 2
striatum 2
brainstem 2
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 110 100.00 Very High Very High Very High
gABA 7 99.92 Very High Very High Very High
narcan 34 99.84 Very High Very High Very High
GABA receptor 3 99.84 Very High Very High Very High
Morphine 90 99.56 Very High Very High Very High
tetrodotoxin 10 99.34 Very High Very High Very High
analgesia 20 99.16 Very High Very High Very High
medulla 2 99.04 Very High Very High Very High
opioid receptor 25 99.02 Very High Very High Very High
alcohol 4 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 13 96.08 Very High Very High Very High
Targeted Disruption 129 95.52 Very High Very High Very High
Aids-related Complex 131 94.64 High High
Generalized Anxiety Disorder 1 91.36 High High
Drug Dependence 2 85.20 High High
Nociception 71 77.92 Quite High
INFLAMMATION 5 75.20 Quite High
Alcohol Addiction 2 61.92 Quite High
Urological Neuroanatomy 2 55.04 Quite High
Pain 39 48.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are inconsistent with a negative autoregulation of endogenous enkephalin release and could suggest the involvement of the diffuse noxious inhibitory controls (DNIC).
Negative_regulation (autoregulation) of Localization (release) of enkephalin associated with enkephalin
1) Confidence 0.53 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7910383 Disease Relevance 0.16 Pain Relevance 1.23
Prolonged alcohol drinking can perturb aspects of this system, including a loss of control of Met-enkephalin levels at the transcriptional and translational levels, and impaired release of Met-enkephalin from tissue sources.
Negative_regulation (impaired) of Localization (release) of Met-enkephalin associated with enkephalin and alcohol
2) Confidence 0.44 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.15 Pain Relevance 0.68
Prolonged alcohol drinking can perturb aspects of this system, including a loss of control of Met-enkephalin levels at the transcriptional and translational levels, and impaired release of Met-enkephalin from tissue sources.
Negative_regulation (loss) of Localization (release) of Met-enkephalin associated with enkephalin and alcohol
3) Confidence 0.44 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.15 Pain Relevance 0.69
The involvement of a presynaptic autoinhibition of endogenous enkephalin release has been suggested as a possible explanation for the paradoxical analgesia induced by low doses of naloxone.
Negative_regulation (autoinhibition) of Localization (release) of enkephalin associated with narcan, enkephalin and analgesia
4) Confidence 0.39 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7910383 Disease Relevance 0.06 Pain Relevance 0.70
The involvement of presynaptic autoinhibition of Met-enkephalin release in naloxone-induced analgesia was studied.
Negative_regulation (autoinhibition) of Localization (release) of Met-enkephalin associated with narcan, enkephalin and analgesia
5) Confidence 0.36 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 3714107 Disease Relevance 0.08 Pain Relevance 0.99
Morphine at 10(-6) to 10(-5)M depressed the high K+-evoked release of Met-enkephalin from slices of the rat brainstem by 12.5-55.9% of control, while naloxone at 10(-6)M significantly enhanced the release by 80.6%.
Negative_regulation (depressed) of Localization (release) of Met-enkephalin in brainstem associated with medulla, narcan, enkephalin and morphine
6) Confidence 0.36 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 3714107 Disease Relevance 0.10 Pain Relevance 1.19
These compared changes in various indexes of enkephalin neuron activity suggest that stimulation of GABAA receptors depresses enkephalin release immediately and for several hours, whereas preproenkephalin gene expression is decreased in a somewhat delayed and longer lasting manner.
Negative_regulation (depresses) of Localization (release) of enkephalin in neuron associated with enkephalin
7) Confidence 0.20 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2170800 Disease Relevance 0 Pain Relevance 0.70
The selective activation of the L-type of voltage-sensitive calcium channels by a dihydropyridine derivative [(+) 202-791] prevented this TTX-induced down-regulation without reducing methionine enkephalin secretion.
Negative_regulation (reducing) of Localization (secretion) of enkephalin associated with tetrodotoxin, calcium channel and enkephalin
8) Confidence 0.16 Published 1991 Journal J. Neurosci. Res. Section Abstract Doc Link 1645773 Disease Relevance 0 Pain Relevance 1.26
Enkephalin biosynthesis and release in mouse striatum are inhibited by GABA receptor stimulation: compared changes in preproenkephalin mRNA and Tyr-Gly-Gly levels.
Negative_regulation (inhibited) of Localization (release) of Enkephalin in striatum associated with gaba receptor and enkephalin
9) Confidence 0.15 Published 1990 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 2170800 Disease Relevance 0 Pain Relevance 0.87
Opioid receptor up-regulation has been observed when endogenous enkephalin release is deficient [30] or when mice were chronically treated with a morphine antagonist [61].
Negative_regulation (deficient) of Localization (release) of enkephalin associated with antagonist, enkephalin, opioid receptor and morphine
10) Confidence 0.11 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.45 Pain Relevance 1.43
Colocalization of enkephalin with VgluT2 was not explored in these studies.
Neg (not) Negative_regulation (explored) of Localization (Colocalization) of enkephalin associated with enkephalin
11) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.70 Pain Relevance 1.20
The endogenous opioids beta-endorphin (10(-10) M), methionine-enkephalin (10(-9) M), and leucine-enkephalin (10(-9) M) inhibited IL-6 secretion as well (p = 0.0051, p = 0.0337, and p = 0.0226, respectively).
Negative_regulation (inhibited) of Localization (secretion) of leucine-enkephalin associated with endogenous opioid and enkephalin
12) Confidence 0.02 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.46

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