INT123726

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 7.20
Pain Relevance 5.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
Notch 17
hippocampus 2
bar 1
nucleus accumbens 1
endothelial cell 1
Notch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 15 100.00 Very High Very High Very High
Chronic pancreatitis 25 99.80 Very High Very High Very High
fluoxetine 17 99.68 Very High Very High Very High
Hippocampus 13 99.28 Very High Very High Very High
Nucleus accumbens 6 99.24 Very High Very High Very High
Delta opioid receptors 2 98.74 Very High Very High Very High
Inflammation 7 98.12 Very High Very High Very High
Bile 15 98.08 Very High Very High Very High
Pain 7 94.56 High High
opioid receptor 4 94.00 High High
Disease Link Frequency Relevance Heat
Cancer 301 99.80 Very High Very High Very High
Pancreatitis 25 99.80 Very High Very High Very High
Neurodegenerative Disease 21 99.28 Very High Very High Very High
Infection 18 99.28 Very High Very High Very High
Mesothelioma 110 98.30 Very High Very High Very High
INFLAMMATION 10 98.12 Very High Very High Very High
Stress Incontinence 6 98.00 Very High Very High Very High
Fibrosis 8 96.48 Very High Very High Very High
Pain 5 94.56 High High
Injury 51 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The function of Notch1 signaling was increased in parallel with neurogenesis in rat hippocampus after chronic fluoxetine administration.
Positive_regulation (increased) of Notch1 in hippocampus associated with hippocampus, neurodegenerative disease and fluoxetine
1) Confidence 0.70 Published 2009 Journal Biol. Pharm. Bull. Section Title Doc Link 19801843 Disease Relevance 0.43 Pain Relevance 0.72
These results indicate that chronic fluoxetine administration activates Notch1 signaling in the hippocampus, and the up-regulation of the Notch1 pathway brought about by chronic fluoxetine administration might partly contribute to increased neurogenesis in hippocampus.
Positive_regulation (activates) of Notch1 in hippocampus associated with hippocampus, neurodegenerative disease and fluoxetine
2) Confidence 0.50 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19801843 Disease Relevance 0.46 Pain Relevance 0.91
Activation of Notch signaling was detectable upon cell stimulation with glucose, steroids, and bile acids.
Positive_regulation (Activation) of Notch in Notch associated with bile
3) Confidence 0.31 Published 2006 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17114010 Disease Relevance 0.67 Pain Relevance 0.66
Notch activation was determined by a specific luciferase-HES-1-reporter gene constructs.
Positive_regulation (activation) of Notch in Notch
4) Confidence 0.31 Published 2006 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17114010 Disease Relevance 0.70 Pain Relevance 0.59
The activation of the delta-opioid receptors in the nucleus accumbens is known to induce a large and rapid increase of accumbal dopamine efflux. (+/-)-TAN-67 (2-methyl-4a(alpha)-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12a(alpha)-octahydro-quinolino[2,3,3,-g]isoquinoline) is a centrally acting non-peptidic delta opioid receptor agent which has recently become available.
Positive_regulation (increase) of TAN-67 in nucleus accumbens associated with nucleus accumbens, dopamine, opioid receptor and delta opioid receptors
5) Confidence 0.23 Published 2005 Journal Neuroscience Section Abstract Doc Link 15590157 Disease Relevance 0.08 Pain Relevance 0.53
For example, Siah1, which belongs to the E3 ubiquitin ligase complex, is known to promote degradation of Numb, and thereby leads to activation of Notch [68]–[71].
Positive_regulation (activation) of Notch in Notch
6) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0 Pain Relevance 0
Interestingly, low levels of cholesterol leads to high expression of Adam10, coding for a protease also known as Kuzbanian, which is essential for Notch activation [55].
Positive_regulation (activation) of Notch in Notch
7) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0 Pain Relevance 0
The Notch pathway is reactivated during chronic pancreatitis.
Positive_regulation (reactivated) of Notch in Notch associated with chronic pancreatitis
8) Confidence 0.22 Published 2006 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17114010 Disease Relevance 0.63 Pain Relevance 0.64
Among the stimuli activating the Notch pathway are steroids, high glucose levels, and bile acids.
Positive_regulation (activating) of Notch in Notch associated with bile
9) Confidence 0.22 Published 2006 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17114010 Disease Relevance 0.61 Pain Relevance 0.63
Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway.
Positive_regulation (activation) of notch in notch associated with chronic pancreatitis
10) Confidence 0.21 Published 2006 Journal J. Gastrointest. Surg. Section Title Doc Link 17114010 Disease Relevance 0.79 Pain Relevance 0.69
The pharmacological effects are mediated by the activation of Notch signaling in the NSC, but not by the inhibition of GSK-3b signaling or inositol depletion, currently popular models to explain mood stabilizers' action.
Neg (not) Positive_regulation (activation) of Notch in Notch
11) Confidence 0.17 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 19108505 Disease Relevance 0.58 Pain Relevance 0.28
Proteolysis mediated Notch signaling regulation
Positive_regulation (mediated) of Notch in Notch
12) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.05 Pain Relevance 0
Interestingly, low levels of cholesterol leads to high expression of Adam10, coding for a protease also known as Kuzbanian, which is essential for Notch activation [55].
Positive_regulation (essential) of Notch in Notch
13) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0 Pain Relevance 0
, whose interaction with NICD leads to transcriptional activation of Notch targets [72]–[74].
Positive_regulation (activation) of Notch in Notch
14) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0 Pain Relevance 0
A genomic expression analysis performed on the CPCs and reported in our previous work indicated that Vegf, Igf1, and Notch signaling pathways are active in the cells both of which have been shown to have pro-vascular and cardioprotective effects [38], [39].
Positive_regulation (active) of Notch in Notch
15) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.24 Pain Relevance 0
Indeed irradiation activated the Notch pathway, as demonstrated by the expression of the Notch target genes Hey1, and its inhibition by the ?
Positive_regulation (activated) of Notch in Notch
16) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.17 Pain Relevance 0
SB431542 did not inhibit radiation-induced Notch activation but it rather enhanced it (Figure S5b, black bar).
Positive_regulation (induced) of Notch in bar
17) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.19 Pain Relevance 0
Notch is activated by ionizing radiation [26] (and our data) and was shown to inhibit angiogenesis [46] and to induce endothelial cell proliferation arrest [47].
Positive_regulation (activated) of Notch in endothelial cell
18) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.12 Pain Relevance 0
These phenomena could be considered to occur in a variety of tissues and cancers where an activated Notch pathway is involved.


Positive_regulation (activated) of Notch in Notch associated with cancer
19) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.10 Pain Relevance 0
This prevents activation of the Notch response (see Text S1, Materials), thus blocking the presenilin-secretase complex and enhancing miR199b-5p expression [50], [51].
Positive_regulation (activation) of Notch in Notch
20) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.77 Pain Relevance 0

General Comments

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