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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.22
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
Notch 4
nucleus accumbens 1
Notch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 15 99.14 Very High Very High Very High
tetrodotoxin 1 98.96 Very High Very High Very High
Nucleus accumbens 6 97.64 Very High Very High Very High
narcan 2 84.68 Quite High
opioid receptor 4 75.00 Quite High
agonist 3 75.00 Quite High
Glutamate 2 75.00 Quite High
Enkephalin 1 72.80 Quite High
Antinociceptive 1 59.84 Quite High
Hyperalgesia 1 56.52 Quite High
Disease Link Frequency Relevance Heat
Cancer 207 99.16 Very High Very High Very High
Injury 171 98.52 Very High Very High Very High
Carcinoma 14 84.72 Quite High
Cleft Palate 1 79.64 Quite High
Targeted Disruption 15 75.76 Quite High
Aging 24 74.80 Quite High
Colon Cancer 6 57.32 Quite High
Hyperalgesia 1 56.52 Quite High
Apoptosis 20 56.48 Quite High
Peripheral Arterial Disease 1 52.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The DPDPE and deltorphin II-induced increase in accumbal dopamine level, but not that of (-)-TAN-67 and (+)-TAN-67, was eliminated by subsequently perfused tetrodotoxin (2 microM) into the nucleus accumbens.
Negative_regulation (eliminated) of TAN-67 in nucleus accumbens associated with nucleus accumbens, tetrodotoxin and dopamine
1) Confidence 0.21 Published 2005 Journal Neuroscience Section Abstract Doc Link 15590157 Disease Relevance 0.06 Pain Relevance 1.11
NS-398 and DAPT inhibited cell proliferation and induced apoptosis in a dose time-dependent manner accompanied by significantly decreased Notch1 activity (P < 0.01), and resulted in a significant down-regulation of Hes1 and NF-kappaB2 (P < 0.01).
Negative_regulation (decreased) of Notch1
2) Confidence 0.19 Published 2008 Journal Dig. Dis. Sci. Section Body Doc Link 18320325 Disease Relevance 0.11 Pain Relevance 0
Notch inhibition, alone or in combination with ALK5 inhibition, however did not rescue the proliferation defect.
Negative_regulation (inhibition) of Notch in Notch
3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.12 Pain Relevance 0
This combined treatment (CT) contains the Tie2 ligand Ang2, the Notch ligand Dll4, a JAK kinase inhibitor, and insulin.
Negative_regulation (inhibitor) of Notch in Notch
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0 Pain Relevance 0
Notch has exceptionally complex biology with several ligands, including Delta and Serrate, and is a widely used as a signaling cassette at various stages of embryogenesis, and has been shown to be downregulated in several invasive tumors [30].
Negative_regulation (downregulated) of Notch in Notch associated with cancer
5) Confidence 0.02 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.51 Pain Relevance 0
Expansion of a cell population expressing a mix of “basal” and “luminal” cytokeratins was also observed in mammary epithelium with impaired Notch signaling [54] and depleted of the PDZ domains-containing scaffold protein Par3, which regulates cell polarity [55].
Negative_regulation (impaired) of Notch in Notch
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.42 Pain Relevance 0

General Comments

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