INT123752

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 16.45
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
brain 4
neuronal 1
eosinophils 1
lung 1
Bax (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 20 99.84 Very High Very High Very High
Morphine 60 99.60 Very High Very High Very High
Neuropeptide 52 99.52 Very High Very High Very High
withdrawal 6 97.38 Very High Very High Very High
methadone 3 97.08 Very High Very High Very High
narcan 1 92.12 High High
depression 1 91.48 High High
antagonist 8 91.40 High High
Central nervous system 32 91.32 High High
Opioid 21 90.92 High High
Disease Link Frequency Relevance Heat
Apoptosis 566 100.00 Very High Very High Very High
Targeted Disruption 127 98.68 Very High Very High Very High
Cognitive Disorder 14 98.24 Very High Very High Very High
Neurodegenerative Disease 15 98.08 Very High Very High Very High
Death 179 97.08 Very High Very High Very High
Dementia 21 96.80 Very High Very High Very High
Convulsion 14 96.64 Very High Very High Very High
Autoimmune Disease 18 95.92 Very High Very High Very High
Cancer 240 94.20 High High
Infection 38 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
immunoreactivity of Bax, a proapoptotic protein regulated in part by VNs in
Regulation (immunoreactivity) of Bax associated with neuropeptide
1) Confidence 0.60 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2643053 Disease Relevance 1.22 Pain Relevance 0.20
First, the interaction of BAX with a binding partner could be affected by low levels of BAX protein, especially if the binding partner had a reduced affinity for BAX in its globular conformation.
Regulation (affected) of BAX protein
2) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.53 Pain Relevance 0.04
In addition to the caspase-3 activation, capsaicin also induced cytochrome c release and decrease in Bcl-2 protein expression with no changes in the level of Bax.
Neg (no) Regulation (changes) of Bax associated with qutenza
3) Confidence 0.40 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15595419 Disease Relevance 1.44 Pain Relevance 0.77
In contrast, there were no alterations in the levels of Bax in capsaicin-treated cells.
Neg (no) Regulation (alterations) of Bax associated with qutenza
4) Confidence 0.39 Published 2007 Journal Food Chem. Toxicol. Section Abstract Doc Link 17306913 Disease Relevance 0.30 Pain Relevance 0.75
The purpose of the present study was to analyse the effects of naltrexone on the expression levels of proteins regulating the extrinsic (FasL and Fas) and the mitochondrial (Bcl-2, Bcl-xL, Bad and Bax) apoptotic pathways, as well as the active fragment of the executioner caspase-3 in the mouse brain.
Regulation (regulating) of Bax in brain associated with apoptosis
5) Confidence 0.37 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16716514 Disease Relevance 0.26 Pain Relevance 0.30
Here, we have analyzed the effects of prolonged heroin administration on sensorimotor and cognitive performance in mice, as well as the associated changes in brain expression of proteins regulating the extrinsic (FasL and Fas) and the mitochondrial (Bcl-2, Bcl-X(L), Bad and Bax) apoptotic pathways.
Regulation (regulating) of Bax in brain associated with cognitive disorder and apoptosis
6) Confidence 0.35 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18201731 Disease Relevance 0.73 Pain Relevance 0.12
Several key molecules, including caspase-3, Bcl-2, BAD and Bax, were modulated by l-THP treatment.
Regulation (modulated) of Bax
7) Confidence 0.30 Published 2010 Journal Toxicol. Lett. Section Abstract Doc Link 20109541 Disease Relevance 0.33 Pain Relevance 0.09
Therefore, in the present study, we have identified pro-apoptotic transcriptional changes, including up-regulation of pro-apoptotic Bax and down-regulation of anti-apoptotic Bcl-2, using western blot assay and by immunohistochemical staining.
Regulation (regulation) of Bax associated with apoptosis
8) Confidence 0.29 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 1.32 Pain Relevance 0.18
However, morphine with H37Ra did not alter the levels of Bcl-2 (Fig. 4A) and Bax (Fig. 4B) in the lung from TLR9 KO mice.
Neg (not) Regulation (alter) of Bax in lung associated with targeted disruption and morphine
9) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 1.08 Pain Relevance 0.80
Within the limitations of this experimental system, BAX-dependent apoptosis in HCT116 cells exhibits an all-or-none response depending on the level of BAX protein present.
Regulation (depending) of BAX protein associated with apoptosis
10) Confidence 0.27 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2964639 Disease Relevance 0.49 Pain Relevance 0
immunoreactivity of Bax, a proapoptotic protein regulated in part by VNs in
Regulation (regulated) of Bax associated with neuropeptide
11) Confidence 0.26 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2643053 Disease Relevance 1.24 Pain Relevance 0.20
Critically, we demonstrated that a very small alteration in the level of BAX was the difference between prolonged cell survival and rapid onset cell death.
Regulation (alteration) of BAX associated with death
12) Confidence 0.24 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.79 Pain Relevance 0
As discussed, many of the most crucial members of apoptotic pathways for these organ sites can be targeted MMR-deficient mutation, most notably BAX, APAF-1, BCL10, CASP-5, FAS and others (105).
Regulation (targeted) of BAX associated with apoptosis
13) Confidence 0.18 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.76 Pain Relevance 0
The apoptotic pathway has not been induced in brain as there is no alteration in pro-apoptotic markers (PUMA, BAX).
Neg (no) Regulation (alteration) of BAX in brain associated with apoptosis
14) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 1.64 Pain Relevance 0.17
Although it is well documented that apoptosis is also regulated by the Bcl-2 family of proteins [55], we do not detect any significant changes in the levels of Bax, Bad, Bcl-2 and Bcl-xL followed by U0126 treatment (data not shown).
Neg (not) Regulation (changes) of Bax associated with apoptosis
15) Confidence 0.15 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.68 Pain Relevance 0
OBJECTIVES: This study analyzes the effects of prolonged administration of methadone and withdrawal on sensorimotor and cognitive performance in mice and explores the associated changes in brain expression of proteins regulating the extrinsic (FasL, Fas, and caspase-8) and the mitochondrial (Bcl-2, Bcl-x(L), Bad, and Bax) apoptotic pathways.
Regulation (regulating) of Bax in brain associated with cognitive disorder, methadone, apoptosis and withdrawal
16) Confidence 0.15 Published 2007 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 17384938 Disease Relevance 0.35 Pain Relevance 0.26
In contrast, induction of apoptosis by DNA-damaging agents (e.g. 5-fluorouracil) and irradiation is mainly dependent on p53-induced up-regulation of the pro-apoptotic Bcl-2 analog Bax.
Regulation (regulation) of Bax associated with apoptosis
17) Confidence 0.11 Published 2009 Journal Radiat Oncol Section Body Doc Link PMC2773776 Disease Relevance 0.91 Pain Relevance 0
Caspase-3 has been shown to be an important effector caspase in eosinophils following mitochondrial activation involving the Bcl-2 family protein Bax.115
Regulation (involving) of Bax in eosinophils
18) Confidence 0.10 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.74 Pain Relevance 0
For example, we found that estrogen promotes p53 phosphorylation [37], but uncouples p53 from its regulation of Bax, a mitochondrial-associated pro-apoptotic factor.
Regulation (regulation) of Bax associated with apoptosis
19) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.67 Pain Relevance 0.08
Indeed, several reports have demonstrated that lithium, in neuronal cell models and in vivo, has neuroprotective activity via the up regulation of antiapoptotic and reduction of proapoptotic Bcl-2 family proteins, including Bcl-2 and Bax [21], [62]–[65].
Regulation (regulation) of Bax in neuronal
20) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.81 Pain Relevance 0.05

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